Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 140 - 140

Published: Jan. 17, 2025

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.

Language: Английский

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Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including potential combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol green tea, has emerged as promising therapeutic agent due to its potent antioxidant anti-inflammatory effects. Chronic neuroinflammation oxidative stress are key pathological mechanisms diseases such Alzheimer's disease (AD) Parkinson's (PD). EGCG neuroprotective efficacy scavenging free radicals, reducing attenuating neuroinflammatory processes. This review discusses molecular EGCG's anti-oxidative chronic neuroinflammation, emphasizing effects on autoimmune responses, neuroimmune system interactions, focusing related AD PD. By elucidating action impact processes, this underscores intervention AD, PD, possibly other Overall, emerges natural compound stress, offering novel avenues strategies treatment disorders.

Language: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 4202 - 4229

Published: June 26, 2024

Abstract Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid disorders with diverse etiology rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, (erythroid‐derived 2)‐like 2, transporter type 4, phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, comprehensive summary flavonoid effects on GLMD lacking. This study reviewed roles natural different structures treatment reported globally past 5 years provides reference for developing as drugs treating GLMD.

Language: Английский

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The Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation for the Management of Obesity and Non-Alcoholic Fatty Liver Disease: Recent Updates

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 206 - 206

Published: Jan. 15, 2025

Epigallocatechin gallate (EGCG) is the predominant bioactive catechin in green tea, and it has been ascribed a range of beneficial health effects. Current increases obesity non-alcoholic fatty liver disease (NAFLD) rates represent persistent burdensome threat to global public health. While many clinical studies have demonstrated that EGCG associated with positive effects on various parameters, including metabolic biomarkers, waist circumference, body weight when consumed by individuals affected NAFLD, there are also some reports suggesting may entail degree hepatotoxicity. The present review provides comprehensive summary extant findings pertaining safety effectiveness managing particular focus how treatment duration dose level affect bioactivity this compound.

Language: Английский

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Navigating the gut-liver axis: the potential of tea to alleviate inflammatory bowel disease and associated metabolic syndromes

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104893 - 104893

Published: Jan. 1, 2025

Language: Английский

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In vitro simulated digestion and fermentation characteristics of polyphenol–polysaccharide complex from Hizikia fusiforme and its effects on the human gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140619 - 140619

Published: Feb. 1, 2025

Language: Английский

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Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Tea polyphenols (TPP) are key contributors to the beneficial health effects of green tea and black tea. However, their molecular mechanisms action remain unclear. This article discusses importance bioavailability TPP in understanding consumption. The systemic is rather high for smaller catechins, low galloyl very or null oligomers polymers from oxidation-derived self-assembled nanomaterials not clearly known. If large weight cannot get into circulation, then biological activities derived studies vitro unlikely be relevant actions internal organs vivo. In that case, interactions with microbiota on epithelial cells gastrointestinal tract important effects. Therefore, different types an factor determining

Language: Английский

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Metabolic restoration: Rhubarb polysaccharides as a shield against non-alcoholic fatty liver disease

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141151 - 141151

Published: Feb. 1, 2025

Language: Английский

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Relationship of tea consumption with hepatic steatosis and fibrosis: findings from a longitudinal RaNCD cohort

BMC Nutrition, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 3, 2025

Language: Английский

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