Опубликована: Янв. 1, 2025
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Язык: Английский
Процитировано
42
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 26, 2024
The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability procedure for synthesizing such is inadequate. Consequently, green biosynthesis, which employs biopolymers, gaining attraction as an environmentally sound alternative to less sustainable approaches. Chitosan-encapsulated exhibit exceptional antibacterial properties, offering a wide range uses. Chitosan, obtained from shrimp shells, aided friendly synthesis high-purity zinc oxide (ZnO NPs) with desirable features extraction yield (41%), deacetylation (88%), crystallinity index (74.54%). particle size ZnO NPs was 12 nm, while that chitosan-ZnO 21 bandgap energies these were 3.98 3.48, respectively. strong action demonstrated NPs, chitosan-ZnO/PVP, particularly against Gram-positive bacteria, making them appropriate therapeutic use. photocatalytic degradation abilities also assessed all nanoparticles. At concentration 6 × 10
Язык: Английский
Процитировано
22
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
The continuous imbalance of the diabetic wound microenvironment is an important cause chronic nonhealing, which manifests as a vicious cycle between excessive accumulation reactive oxygen species (ROS) and abnormal healing. Regulating by suppressing inflammation, oxidative stress, bacterial infection key challenge in treating wounds. In this study, ROS-responsive hydrogels are developed composed silk fibroin methacrylated (SFMA), modified collagen type III (rCol
Язык: Английский
Процитировано
18
Plant Physiology and Biochemistry, Год журнала: 2024, Номер 211, С. 108704 - 108704
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
14
Heliyon, Год журнала: 2024, Номер 10(21), С. e39636 - e39636
Опубликована: Окт. 19, 2024
Язык: Английский
Процитировано
14
Journal of Molecular Liquids, Год журнала: 2024, Номер 403, С. 124841 - 124841
Опубликована: Апрель 27, 2024
Язык: Английский
Процитировано
10
Deleted Journal, Год журнала: 2024, Номер 1(1)
Опубликована: Окт. 29, 2024
The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated
Язык: Английский
Процитировано
10
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Апрель 9, 2024
Modern imaging strategies are paramount to studying living systems such as cells, bacteria, and fungi their response pathogens, toxicants, nanomaterials (NMs) modulated by exposure environmental factors. The need understand the processes mechanisms of damage, healing, cell survivability continues motivate development alternative strategies. Of particular interest is use label-free techniques (microscopy procedures that do not require sample staining) minimize interference biological foreign marking substances reduce intense light potential photo-toxicity effects. This review focuses on synergic capabilities atomic force microscopy (AFM) a well-developed robust strategy with demonstrated applications unravel intimate details in biomedical applications, label-free, fast, enduring Holotomographic Microscopy (HTM) strategy. HTM technique combines holography tomography using low intensity continuous illumination laser investigate (quantitatively non-invasively) microorganisms, thin tissue generating three-dimensional (3D) images monitoring real-time inner morphological changes. We first operating principles form basis for complementary provided these regarding surface internal information AFM, which essential complimentary several areas interaction NMs organisms. First, AFM can provide superb resolution morphology biomechanical characterization. Second, quantitative phase enable modeling quantification volume, area, protein content, mass density main components cells including microbiological systems. These result from directly quantifying refractive index changes without requiring fluorescent markers or chemicals. As such, ideal long-term organisms conditions close natural settings. present case-based principal uses both contributions nanomedicine nanotoxicology (study harmful effects organisms), emphasizing cancer infectious disease control. impact sequential provides clear drive adopting interdependent fundamental tools.
Язык: Английский
Процитировано
9
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116997 - 116997
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
9
Опубликована: Авг. 6, 2024
Artificial intelligence (AI) is revolutionizing plant sciences by enabling precise species identification, early disease diagnosis, crop yield prediction, and precision agriculture optimization. AI uses machine learning image recognition to aid ecological research biodiversity conservation. It plays a crucial role in breeding accelerating the development of resilient, high-yielding crops with desirable traits. models using climate soil data contribute sustainable food security. In phenotyping, automates measurement analysis characteristics, enhancing our understanding growth. Ongoing aims improve models’ robustness interpretability while addressing privacy algorithmic biases. Interdisciplinary collaboration essential fully harness AI’s potential for sustainable, food-secure future.
Язык: Английский
Процитировано
8