Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

Antioxidants, Год журнала: 2020, Номер 9(4), С. 346 - 346

Опубликована: Апрель 23, 2020

Over the last decades, there has been a substantial increase in prevalence of mental health disorders, including an increased depression, anxiety, cognitive, and sleep disorders. Diet its bioactive components have recognized among modifiable risk factors, possibly influencing their pathogenesis. This review aimed to summarize molecular mechanisms underlying putative beneficial effects toward brain different dietary such as micro- macronutrient intake habits, feeding time circadian rhythm. The role hormonal homeostasis context glucose metabolism adiponectin regulation impact on systemic neuro-inflammation also considered deepened. In addition, effect individual molecules exerting antioxidant activities acting anti-inflammatory agents, omega-3 fatty acids polyphenols, for central nervous system via modulation adult neurogenesis, synaptic neuronal plasticity, microglia activation summarized. An overview gut–brain axis inflammation oxidative stress provided. Finally, association with

Язык: Английский

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Seaweed Components as Potential Modulators of the Gut Microbiota

Marine Drugs, Год журнала: 2021, Номер 19(7), С. 358 - 358

Опубликована: Июнь 23, 2021

Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through enhancement bacterial diversity and abundance. An imbalance bacteria has been linked to development disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, cancer. This review outlines current knowledge from in vitro vivo studies concerning potential therapeutic application seaweed-derived polysaccharides, polyphenols peptides modulate diet. Polysaccharides fucoidan, laminarin, alginate, ulvan porphyran unique seaweeds. Several have shown their act prebiotics positively microbiota. Prebiotics enhance populations often production short chain fatty acids, energy for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, induce apoptosis colon cancer cells. The oral bioaccessibility bioavailability seaweed is also discussed, including advantages limitations static dynamic models versus ex methods. Seaweed bioactives show use prevention and, some instances, treatment human disease. However, it necessary confirm these potential, large-scale clinical trials. Where possible, we cited information

Язык: Английский

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Polyphenols in Alzheimer’s Disease and in the Gut–Brain Axis

Microorganisms, Год журнала: 2020, Номер 8(2), С. 199 - 199

Опубликована: Янв. 31, 2020

Polyphenolic antioxidants, including dietary plant lignans, modulate the gut–brain axis, which involves transformation of these polyphenolic compounds into physiologically active and neuroprotector (called human lignans) through gut bacterial metabolism. These metabolites exert their neuroprotective effects in various neurodegenerative diseases, such as Alzheimer’s disease (AD) Parkinson’s (PD), also have protective against other cardiovascular cancer, diabetes. For example, enterolactone enterodiol, therapeutically relevant polyphenols, are formed secondary non-flavonoid found plant-based foods. acetylcholinesterase inhibitors, thereby potential applications therapeutics AD neurological diseases. Polyphenols advanced glycation end product (AGE) inhibitors (antiglycating agents), cases AD. Thus, metabolism lignans results formation polyphenols—some enhanced blood–brain barrier permeability. It is hypothesized that metabolism-derived when combined with nanoparticle-based (BBB)-targeted drug delivery, may prove to be effective for disorders, traumatic brain injury (TBI), AD, PD. This mini-review addresses role focusing on

Язык: Английский

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The multifunctional roles of flavonoids against the formation of advanced glycation end products (AGEs) and AGEs-induced harmful effects

Trends in Food Science & Technology, Год журнала: 2020, Номер 103, С. 333 - 347

Опубликована: Июнь 30, 2020

Язык: Английский

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The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke

European Journal of Pharmacology, Год журнала: 2021, Номер 914, С. 174660 - 174660

Опубликована: Дек. 1, 2021

Язык: Английский

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The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(22), С. 8653 - 8653

Опубликована: Ноя. 17, 2020

Anthocyanins are naturally occurring polyphenols commonly found in fruits and vegetables. Numerous studies have described that anthocyanin-rich foods may play a crucial role the prevention treatment of different pathological conditions, which encouraged their consumption around world. exhibit significant neuroprotective role, mainly due to well-recognized antioxidant anti-inflammatory properties. Neuroinflammation is an intricate process relevant both homeostatic circumstances. Since progression several neurological disorders relies on neuroinflammatory process, targeting brain inflammation has been considered promising strategy those conditions. Recent data shown anti-neuroinflammatory abilities many anthocyanins metabolites onset development disorders. In this review, it will be discussed importance applicability these polyphenolic compounds as agents also scrutinized molecular mechanisms underlying modulation neuroinflammation by natural context diseases.

Язык: Английский

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Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Nutrients, Год журнала: 2023, Номер 15(2), С. 449 - 449

Опубликована: Янв. 14, 2023

Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss essential motor cognitive functions, such as mobility, learning sensation. Neurodegeneration affects millions people worldwide, no integral cure has been created yet. Here, bioactive compounds have proven exert numerous beneficial effects due remarkable bioactivity, so they could be considered great options development new neuroprotective strategies. Phenolic bioactives reported found in edible part plants; however, over last years, a large amount research focused on phenolic richness that plant by-products possess, which sometimes even exceeds content pulp. Thus, possible application an emergent technique also optimal strategy revalorize these agricultural residues (those originated from processing). This review aims summarize main triggers neurodegeneration, revise state art extracts role avoiding neurodegeneration discuss how effects. For this purpose, diverse search studies conducted, gathering number papers where were used strong sources properties. Finally, although lack investigation is quite greatly limits use compounds, phenolics remain attractive into multifactorial anti-neurodegenerative nutraceuticals.

Язык: Английский

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A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2022, Номер 21(5), С. 3931 - 3962

Опубликована: Авг. 29, 2022

Abstract A large number of epidemiological studies have shown that consumption fruits, vegetables, and beverages rich in (poly)phenols promote numerous health benefits from cardiovascular to neurological diseases. Evidence on has been applied mainly flavonoids, yet the role phenolic acids largely overlooked. Such phenolics present food combine with those resulting gut microbiota catabolism flavonoids chlorogenic produced by endogenous pathways, concentrations low molecular weight metabolites human circulation. Independently origin, intervention using diets (poly)phenols, a total 137 detected quantified circulation unknown biological function. In this review, we will pinpoint two main aspects metabolites: (i) responsible for their generation, (ii) analysis (quali‐ quantitative) respective pharmacokinetics. doing so, aim drive scientific advances regarding ubiquitous roles physiologically relevant under (patho)physiologically conditions humans.

Язык: Английский

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Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation

Redox Biology, Год журнала: 2023, Номер 61, С. 102622 - 102622

Опубликована: Фев. 1, 2023

The Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor able to control complex transcriptional processes in several cell types, which has been correlated with various diseases, including inflammatory bowel diseases (IBD). Numerous studies have described different compounds as ligands of this receptor, like xenobiotics, natural compounds, and host-derived metabolites. Dietary (poly)phenols studied regarding their pleiotropic activities (e.g., neuroprotective anti-inflammatory), but AHR modulatory capabilities also considered. However, dietary are submitted extensive metabolism the gut microbiota). Thus, resulting phenolic metabolites could be key players modulating since they ones that reach cells may exert effects on throughout other organs. This review aims at comprehensive search for most abundant detected quantified humans understand how many modulators what impact processes. Even though anti-inflammatory capacities, only 1 metabolite, modulator, evaluated intestinal models. Searching novel strategy against IBD.

Язык: Английский

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Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 7, 2024

With the increasing of aging population and consumption high-fat diets (HFD), incidence Alzheimer's disease (AD) has skyrocketed. Natural antioxidants show promising potential in prevention AD, as oxidative stress neuroinflammation are two hallmarks AD pathogenesis. Here, we showed that quinic acid (QA), a polyphenol derived from millet, significantly decreased HFD-induced brain levels Aβ p-Tau. Examination gut microbiota suggested improvement composition HFD mice after QA treatment. Metabolomic analysis significant increase microbial tryptophan metabolites indole-3-acetic (IAA) kynurenic (KYNA) by QA. In addition, IAA KYNA negative correlation with pro-inflammatory factors indicators. Further experiments on proved could reproduce effects suppress inflammation decrease Transcriptomics administration revealed inhibition DR3/IKK/NF-κB signaling pathway IAA. conclusion, this study demonstrated counteract regulating inflammatory via metabolites.

Язык: Английский

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