Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

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Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7161 - 7181

Published: Feb. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Language: Английский

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Visible and Red Light-Triggered Anticancer Profile of a Ferrocene-Re(I)-Tricarbonyl Conjugate: Experimental and Theoretical Studies

Langmuir, Journal Year: 2024, Volume and Issue: 40(23), P. 12226 - 12238

Published: May 30, 2024

We have red-shifted the light absorbance property of a Re(I)-tricarbonyl complex via distant conjugation ferrocene moiety and developed novel ReFctp, [Re(Fctp)(CO)3Cl], where Fctp = 4′-ferrocenyl-2,2′:6′,2″-terpyridine. ReFctp showed green to red absorption ability blue emission, indicating its potential for photodynamic therapy (PDT) application. The introduced ferrocene-based transitions, which lie at higher wavelength within PDT therapeutic window. time-dependent density functional theory excited state calculations revealed an efficient intersystem crossing is helpful PDT. elicited both type I II pathways reactive oxygen species (ROS) generation facilitated NADH (1,4-dihydro-nicotinamide adenine dinucleotide) oxidation upon exposure visible light. Importantly, effective penetration through layers clinically relevant 3D multicellular tumor spheroids localized primarily in mitochondria (Pearson's correlation coefficient, PCC 0.65) A549 cancer cells. produced more than 20 times phototoxicity (IC50 ∼1.5 μM) by inducing ROS altering mitochondrial membrane cells nonferrocene analogue Retp, [Re(CO)3(tp)Cl], tp 2,2′:6′,2″-terpyridine. induced apoptotic mode cell death with notable photocytotoxicity index (PI, PI IC50dark/IC50light) selectivity (SI, SI normal cell's IC50dark/cancer IC50light) range 25–33.

Language: Английский

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Push-pull effect – how to effectively control photoinduced intramolecular charge transfer processes in rhenium(I) chromophores with ligands of D–A or D–π–A structure

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The latest developments in controlling the photoinduced processes of Re( i ) tricarbonyl complexes bearing D–A and D–π–A ligands with six different diimine cores decorated by various electron-rich amine, sulphur-based π-conjugated aryl groups.

Language: Английский

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Cancer Phototherapy by CO Releasing Terpyridine-Based Re(I) Tricarbonyl Complexes via ROS Generation and NADH Oxidation

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(32), P. 13591 - 13601

Published: Jan. 1, 2024

Here, we have synthesized and characterized three visible light responsive terpyridine based-Re(I)-tricarbonyl complexes; [Re(CO)

Language: Английский

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Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

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Cyclam-based molybdenum carbonyl complexes as a novel class of cytotoxic agents

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cyclam-based Mo(0) carbonyl complexes revealed important anticancer activity against human breast cancer cell lines.

Language: Английский

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Sonodynamic Therapy

Resonance, Journal Year: 2025, Volume and Issue: 30(3), P. 341 - 353

Published: April 3, 2025

Language: Английский

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Structural Features and Photophysical and Antiproliferative Properties of Me₂N-pbt-Cycloplatinated Complexes with Picolinate Ligands

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

2-(4-dimethylaminophenyl)benzothiazolate (Me2N-pbt)-cyclometalated platinum complexes containing four different picolinate ligands, [Pt(Me2N-pbt)(R-pic-κN∧O)] (R = 3-H 1, 3-NH2 2, 3-OH 3, 4-COOH 4) were prepared and examined for their photophysical properties, singlet oxygen production, bioactivity. X-ray studies of 1 3·CHCl3 revealed aggregation to give 1D infinite chains. They showed phosphorescent emissions essentially associated with metal-perturbed 3ILCT excited states in 1-3 mixed 3LL'CT/3ILCT (L Me2N-pbt, L' pic) 4, agreement theoretical calculations. Their tendency self-assemble was demonstrated films (1, 3) DMSO/H2O (3). Complexes photosensitization quantum yields (ϕΔ 1O2) the range 13-17%. The vitro biological activity toward selected cell lines dark conditions under 5 min irradiation at 450 nm tested. Complex 3 highest phototoxicity up 10 times improvement antiproliferative upon irradiation, EC50 values nanomolar range, related overproduction ROS conditions, further enhanced irradiation. 1-4 did not bind DNA, while most potent complex interaction BSA photooxidation NADH. Finally, intracellular dose-dependent production MDA-MB-231 cells treated observed stimulated blue light

Language: Английский

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Design, development, and therapeutic applications of rhenium tricarbonyl complexes

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: May 15, 2025

Language: Английский

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