Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 275, С. 116595 - 116595

Опубликована: Июнь 12, 2024

Язык: Английский

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Dimethylallylated stilbenoids by chemo-selective prenyltransferases and their α-glucosidase inhibitory effects

Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108261 - 108261

Опубликована: Фев. 7, 2025

Язык: Английский

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α-Glucosidase inhibitory peptides from the enzymolysis of Semen Ziziphi Spinosae protein using an ultrasound-assisted protease: Preparation and inhibitory mechanism

Food Research International, Год журнала: 2025, Номер unknown, С. 116282 - 116282

Опубликована: Март 1, 2025

Язык: Английский

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Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 133726 - 133726

Опубликована: Июль 31, 2024

Язык: Английский

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Protein Tyrosine Phosphatase 1B (PTP1B): A Comprehensive Review of Its Role in Pathogenesis of Human Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7033 - 7033

Опубликована: Июнь 27, 2024

Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways and results in numerous human diseases. In particular, its involvement has been well documented the pathogenesis metabolic disorders (diabetes mellitus type I II, fatty liver disease, obesity); neurodegenerative diseases (Alzheimer's Parkinson's disease); major depressive disorder; calcific aortic valve disease; as several cancer types. Given this multitude therapeutic applications, shortly after identification PTP1B role, pursuit to introduce safe selective enzyme inhibitors began. Regrettably, efforts undertaken so far have proved unsuccessful, since all proposed failed, or are yet complete, clinical trials. Intending aid introduction new generation inhibitors, work collects organizes current state art. review intends elucidate intricate relations between associated with overexpression PTP1B, we believe that it is utmost significance establish follow a brand-new holistic approach treatment interconnected conditions. With mind, comprehensive aims validate promising molecular target, reinforce future research direction.

Язык: Английский

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Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Авг. 14, 2024

Язык: Английский

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Insights into inhibitory action and interaction of bisdemethoxycurcumin on tyrosinase: Spectroscopic and docking analysis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136655 - 136655

Опубликована: Окт. 16, 2024

Язык: Английский

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Novel coumarin-thiazolidine-2,4-dione hybrids as potential α-glucosidase inhibitors: Synthesis and bioactivity evaluation

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140481 - 140481

Опубликована: Окт. 1, 2024

Язык: Английский

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Effect of polysaccharides on the inhibition and binding ability of hesperetin-copper(II) complex on α-glucosidase

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114564 - 114564

Опубликована: Фев. 14, 2025

Язык: Английский

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Depolymerization of oyster glycosaminoglycans for the enhancement of α-glucosidase inhibition and its application in hypoglycemic studies

Food Research International, Год журнала: 2025, Номер 205, С. 116008 - 116008

Опубликована: Фев. 14, 2025

Язык: Английский

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