Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 116595 - 116595

Published: June 12, 2024

Language: Английский

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Dimethylallylated stilbenoids by chemo-selective prenyltransferases and their α-glucosidase inhibitory effects

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108261 - 108261

Published: Feb. 7, 2025

Language: Английский

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α-Glucosidase inhibitory peptides from the enzymolysis of Semen Ziziphi Spinosae protein using an ultrasound-assisted protease: Preparation and inhibitory mechanism

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116282 - 116282

Published: March 1, 2025

Language: Английский

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Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133726 - 133726

Published: July 31, 2024

Language: Английский

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Protein Tyrosine Phosphatase 1B (PTP1B): A Comprehensive Review of Its Role in Pathogenesis of Human Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7033 - 7033

Published: June 27, 2024

Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways and results in numerous human diseases. In particular, its involvement has been well documented the pathogenesis metabolic disorders (diabetes mellitus type I II, fatty liver disease, obesity); neurodegenerative diseases (Alzheimer's Parkinson's disease); major depressive disorder; calcific aortic valve disease; as several cancer types. Given this multitude therapeutic applications, shortly after identification PTP1B role, pursuit to introduce safe selective enzyme inhibitors began. Regrettably, efforts undertaken so far have proved unsuccessful, since all proposed failed, or are yet complete, clinical trials. Intending aid introduction new generation inhibitors, work collects organizes current state art. review intends elucidate intricate relations between associated with overexpression PTP1B, we believe that it is utmost significance establish follow a brand-new holistic approach treatment interconnected conditions. With mind, comprehensive aims validate promising molecular target, reinforce future research direction.

Language: Английский

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Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Language: Английский

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Insights into inhibitory action and interaction of bisdemethoxycurcumin on tyrosinase: Spectroscopic and docking analysis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136655 - 136655

Published: Oct. 16, 2024

Language: Английский

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Novel coumarin-thiazolidine-2,4-dione hybrids as potential α-glucosidase inhibitors: Synthesis and bioactivity evaluation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140481 - 140481

Published: Oct. 1, 2024

Language: Английский

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Effect of polysaccharides on the inhibition and binding ability of hesperetin-copper(II) complex on α-glucosidase

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114564 - 114564

Published: Feb. 14, 2025

Language: Английский

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Depolymerization of oyster glycosaminoglycans for the enhancement of α-glucosidase inhibition and its application in hypoglycemic studies

Food Research International, Journal Year: 2025, Volume and Issue: 205, P. 116008 - 116008

Published: Feb. 14, 2025

Language: Английский

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