Alpha- glucosidase inhibition analysis and in silico studies of new tetrahydroquinazolin-4(1H)-one derivatives

Results in Chemistry, Год журнала: 2024, Номер 9, С. 101669 - 101669

Опубликована: Июль 1, 2024

In this work, a new series 3-phenylamine-2,3-dihydroquinazolin-4(1H)-one-phenoxy-acetamid derivatives 7a-m was designed using by hybridization of effective pharmacophores the potent anti-α-glucosidase agents. These compounds were synthesized simple and efficient chemical reactions evaluated for their inhibitory activity against α-glucosidase. Our results demonstrated that all more active than positive control. Particularly, compound 7h as most 63.2-folds Kinetic study revealed 7 h competitive α-glucosidase inhibitor. Furthermore, docking dynamics studied. The latter in silico studied with favorable binding energy occupied site

Язык: Английский

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Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors

Heliyon, Год журнала: 2024, Номер 10(20), С. e38376 - e38376

Опубликована: Сен. 24, 2024

Язык: Английский

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Design, synthesis and enzymatic inhibition evaluation of novel 4-Hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 280, С. 116938 - 116938

Опубликована: Окт. 4, 2024

Язык: Английский

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Insights into the inhibitory activity and mechanism of natural compounds from Rhinacanthus nasutus on α-glucosidase through kinetic, molecular docking, and molecular dynamics studies

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140527 - 140527

Опубликована: Окт. 1, 2024

Язык: Английский

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Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 282, С. 117053 - 117053

Опубликована: Ноя. 13, 2024

Язык: Английский

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