Alpha- glucosidase inhibition analysis and in silico studies of new tetrahydroquinazolin-4(1H)-one derivatives

Results in Chemistry, Journal Year: 2024, Volume and Issue: 9, P. 101669 - 101669

Published: July 1, 2024

In this work, a new series 3-phenylamine-2,3-dihydroquinazolin-4(1H)-one-phenoxy-acetamid derivatives 7a-m was designed using by hybridization of effective pharmacophores the potent anti-α-glucosidase agents. These compounds were synthesized simple and efficient chemical reactions evaluated for their inhibitory activity against α-glucosidase. Our results demonstrated that all more active than positive control. Particularly, compound 7h as most 63.2-folds Kinetic study revealed 7 h competitive α-glucosidase inhibitor. Furthermore, docking dynamics studied. The latter in silico studied with favorable binding energy occupied site

Language: Английский

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Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38376 - e38376

Published: Sept. 24, 2024

Language: Английский

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Design, synthesis and enzymatic inhibition evaluation of novel 4-Hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116938 - 116938

Published: Oct. 4, 2024

Language: Английский

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Insights into the inhibitory activity and mechanism of natural compounds from Rhinacanthus nasutus on α-glucosidase through kinetic, molecular docking, and molecular dynamics studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140527 - 140527

Published: Oct. 1, 2024

Language: Английский

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Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117053 - 117053

Published: Nov. 13, 2024

Language: Английский

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