Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
An
efficient,
practical,
and
scalable
Cs
2
CO
3
‐catalyzed
[4+2]
annulation
reaction
between
ynones
acetates
is
presented,
wherein
serve
as
the
four‐atom
partners.
This
methodology
facilitates
synthesis
of
substituted
2‐pyrones
with
yields
ranging
from
good
to
excellent.
The
ready
availability
starting
materials,
coupled
simplicity
protocol,
renders
this
approach
highly
amenable
preparation
a
diverse
range
2‐pyrones.
Furthermore,
feasibility
on
gram
scale
its
application
in
potent
selective
cyclooxygenase‐2
inhibitor
underscore
practical
significance
utility
method.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(15), С. 10852 - 10860
Опубликована: Июль 27, 2021
A
novel
synthesis
of
2-(cyanomethyl)benzoic
esters
from
indanone
derivatives
has
been
established.
This
reaction
proceeds
via
a
deprotonation
alcohols
with
chemical
base,
followed
by
nucleophilic
addition
to
indanones
and
Beckmann
fragmentation.
In
addition,
this
could
also
work
under
electrochemical
conditions,
no
external
bases
were
needed.
mild
method
offers
strategy
for
the
late-stage
functionalization
various
natural
alcohols.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
An
efficient,
practical,
and
scalable
Cs
2
CO
3
‐catalyzed
[4+2]
annulation
reaction
between
ynones
acetates
is
presented,
wherein
serve
as
the
four‐atom
partners.
This
methodology
facilitates
synthesis
of
substituted
2‐pyrones
with
yields
ranging
from
good
to
excellent.
The
ready
availability
starting
materials,
coupled
simplicity
protocol,
renders
this
approach
highly
amenable
preparation
a
diverse
range
2‐pyrones.
Furthermore,
feasibility
on
gram
scale
its
application
in
potent
selective
cyclooxygenase‐2
inhibitor
underscore
practical
significance
utility
method.
