Molecular Catalysis, Год журнала: 2024, Номер 556, С. 113899 - 113899
Опубликована: Фев. 6, 2024
Язык: Английский
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(8), С. 1708 - 1713
Опубликована: Янв. 1, 2024
A visible-light-induced radical relay cyclization/C-C bond formation of quinoxalin-2(1
Язык: Английский
Процитировано
26
European Journal of Organic Chemistry, Год журнала: 2023, Номер unknown
Опубликована: Сен. 11, 2023
Abstract The multicomponent reactions of quinoxalin‐2(1 H )‐ones has attracted considerable interest due to their significant biological and chemical activities. very recent advances (from 2021 the beginning 2023) on radical three‐component cascade reaction )‐one derivatives at C3 position were summarized in this mini‐review. According kind types involved, some representative examples detailed mechanism have been categorized discussed. red front was covered by Figure 1.
Язык: Английский
Процитировано
37
Organic Letters, Год журнала: 2024, Номер 26(15), С. 3014 - 3019
Опубликована: Март 28, 2024
The radical relay provides an effective paradigm for intermolecular assembly to achieve functionalization across remote chemical bonds. Herein, we report the first 1,3-carbocarbonylation of α-carbonyl alkyl bromides two separate C═C reaction is highly chemo- and regioselective, with C(sp3)–C(sp3) bonds one C═O bond formed in a single orchestrated operation. In addition, synthesis method under mild conditions using inexpensive copper as catalyst allows facile access structurally diverse products. plausible mechanism investigated through series control experiments, including trapping, clock critical intermediate 18O labeling experiment.
Язык: Английский
Процитировано
12
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(4), С. 635 - 697
Опубликована: Янв. 13, 2024
Abstract In recent years, the interest to develop cyclizations promoted by visible light has been gaining a lot of attention due its sustainability aspect. this review, we summarize most important advances in period describing methods used generate different ring sizes, while focusing on mechanistic details these reactions.
Язык: Английский
Процитировано
8
Organic Letters, Год журнала: 2022, Номер 24(13), С. 2556 - 2561
Опубликована: Март 29, 2022
A visible-light-induced photocatalyst-free three-component radical cascade bicyclization has been achieved to obtain diverse difluoroamidosulfonylated dihydrobenzofurans in moderate good yields. This protocol avoids potential toxicity and the tedious removal procedure for photocatalysts also features mild reaction conditions a functional group tolerance. Moreover, mechanistic investigations reveal formation of charge-transfer complex involvement an intramolecular 1,5-hydrogen atom transfer process this transformation.
Язык: Английский
Процитировано
24
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(9), С. 6334 - 6344
Опубликована: Апрель 15, 2024
A one-pot strategy for deoxygenative alkylation of alcohols with quinoxalin-2(1H)-ones was developed by using xanthate salts as alcohol-activating groups radical generation in the presence tricyclohexylphosphine under visible-light-promoted conditions. The remarkable features this reaction include a broad substrate scope, excellent functional group tolerance, mild conditions, and simple operation. Moreover, synthetic utility validated success two-step reactions, scale-up synthesis, chemoselective monodeoxygenation diols.
Язык: Английский
Процитировано
5
Molecular Catalysis, Год журнала: 2024, Номер 558, С. 113999 - 113999
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
4
ChemistrySelect, Год журнала: 2025, Номер 10(12)
Опубликована: Март 1, 2025
Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.
Язык: Английский
Процитировано
0
Advanced Synthesis & Catalysis, Год журнала: 2022, Номер 364(10), С. 1750 - 1756
Опубликована: Апрель 1, 2022
Abstract A mild and safe photochemical methodology has been developed to access difluoroamidosulfonylated dioxodibenzothiazepines via three‐component radical bicyclization cascades. This photocatalyst‐free transformation avoids cumbersome photocatalyst removal procedure potential toxicity. Mechanistic experiments reveal the generation of an electron donor‐acceptor (EDA) complex in reaction process. Moreover, synthetic value protocol is further demonstrated by gram‐scale reaction, conversion product total synthesis antidepressant drug. magnified image
Язык: Английский
Процитировано
15
New Journal of Chemistry, Год журнала: 2023, Номер 47(22), С. 10744 - 10750
Опубликована: Янв. 1, 2023
A photocatalyst-free visible-light-promoted tandem intramolecular cyclization/heteroarylation between bromodifluoroacetamides and quinoxalin-2(1 H )-ones or coumarins was developed. The process could generate a broad range of α , -difluoro-γ-lactams.
Язык: Английский
Процитировано
9