Molecular Catalysis, Journal Year: 2024, Volume and Issue: 570, P. 114685 - 114685
Published: Nov. 21, 2024
Language: Английский
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(8), P. 1708 - 1713
Published: Jan. 1, 2024
A visible-light-induced radical relay cyclization/C-C bond formation of quinoxalin-2(1
Language: Английский
Citations
26
European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 11, 2023
Abstract The multicomponent reactions of quinoxalin‐2(1 H )‐ones has attracted considerable interest due to their significant biological and chemical activities. very recent advances (from 2021 the beginning 2023) on radical three‐component cascade reaction )‐one derivatives at C3 position were summarized in this mini‐review. According kind types involved, some representative examples detailed mechanism have been categorized discussed. red front was covered by Figure 1.
Language: Английский
Citations
36
Organic Letters, Journal Year: 2024, Volume and Issue: 26(15), P. 3014 - 3019
Published: March 28, 2024
The radical relay provides an effective paradigm for intermolecular assembly to achieve functionalization across remote chemical bonds. Herein, we report the first 1,3-carbocarbonylation of α-carbonyl alkyl bromides two separate C═C reaction is highly chemo- and regioselective, with C(sp3)–C(sp3) bonds one C═O bond formed in a single orchestrated operation. In addition, synthesis method under mild conditions using inexpensive copper as catalyst allows facile access structurally diverse products. plausible mechanism investigated through series control experiments, including trapping, clock critical intermediate 18O labeling experiment.
Language: Английский
Citations
12
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(4), P. 635 - 697
Published: Jan. 13, 2024
Abstract In recent years, the interest to develop cyclizations promoted by visible light has been gaining a lot of attention due its sustainability aspect. this review, we summarize most important advances in period describing methods used generate different ring sizes, while focusing on mechanistic details these reactions.
Language: Английский
Citations
7
Organic Letters, Journal Year: 2022, Volume and Issue: 24(13), P. 2556 - 2561
Published: March 29, 2022
A visible-light-induced photocatalyst-free three-component radical cascade bicyclization has been achieved to obtain diverse difluoroamidosulfonylated dihydrobenzofurans in moderate good yields. This protocol avoids potential toxicity and the tedious removal procedure for photocatalysts also features mild reaction conditions a functional group tolerance. Moreover, mechanistic investigations reveal formation of charge-transfer complex involvement an intramolecular 1,5-hydrogen atom transfer process this transformation.
Language: Английский
Citations
23
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(9), P. 6334 - 6344
Published: April 15, 2024
A one-pot strategy for deoxygenative alkylation of alcohols with quinoxalin-2(1H)-ones was developed by using xanthate salts as alcohol-activating groups radical generation in the presence tricyclohexylphosphine under visible-light-promoted conditions. The remarkable features this reaction include a broad substrate scope, excellent functional group tolerance, mild conditions, and simple operation. Moreover, synthetic utility validated success two-step reactions, scale-up synthesis, chemoselective monodeoxygenation diols.
Language: Английский
Citations
5
Molecular Catalysis, Journal Year: 2024, Volume and Issue: 558, P. 113999 - 113999
Published: March 11, 2024
Language: Английский
Citations
4
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)
Published: March 1, 2025
Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.
Language: Английский
Citations
0
Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(10), P. 1750 - 1756
Published: April 1, 2022
Abstract A mild and safe photochemical methodology has been developed to access difluoroamidosulfonylated dioxodibenzothiazepines via three‐component radical bicyclization cascades. This photocatalyst‐free transformation avoids cumbersome photocatalyst removal procedure potential toxicity. Mechanistic experiments reveal the generation of an electron donor‐acceptor (EDA) complex in reaction process. Moreover, synthetic value protocol is further demonstrated by gram‐scale reaction, conversion product total synthesis antidepressant drug. magnified image
Language: Английский
Citations
15
New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(22), P. 10744 - 10750
Published: Jan. 1, 2023
A photocatalyst-free visible-light-promoted tandem intramolecular cyclization/heteroarylation between bromodifluoroacetamides and quinoxalin-2(1 H )-ones or coumarins was developed. The process could generate a broad range of α , -difluoro-γ-lactams.
Language: Английский
Citations
8