Tetrahedron, Год журнала: 2023, Номер 148, С. 133707 - 133707
Опубликована: Окт. 19, 2023
Язык: Английский
Chemical Communications, Год журнала: 2023, Номер 59(27), С. 4036 - 4039
Опубликована: Янв. 1, 2023
The synthesis of N-naphthyl pyrazoles has been realized by the direct three-component reactions enaminones, aryl hydrazine hydrochlorides and internal alkynes via Rh(III) catalysis. synthetic employing simple substrates lead to simultaneous construction dual cyclic moieties, including a pyrazole ring phenyl ring, sequential formation two C-N three C-C bonds.
Язык: Английский
Процитировано
33
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(11), С. 7188 - 7198
Опубликована: Май 12, 2023
Rongalite has been used as a cheap and efficient carbon synthon for the synthesis of divergent N-heteroaromatics, including different pyridines quinolines. The selective products can be achieved by employing enaminones or enaminones/anilines reaction partners. In addition, compared with using conventional aldehyde synthons, rongalite displays an evident advantage in providing considerably higher product yields under milder conditions. GC-MS analysis process performed to probe possible mechanism.
Язык: Английский
Процитировано
32
Synthesis, Год журнала: 2023, Номер 55(18), С. 2911 - 2925
Опубликована: Фев. 20, 2023
Abstract This review highlights recent progress in electrochemical cascade cyclization reactions for the synthesis of carbon rings and heterocycles, such as pyridines, quinolines, phenanthridines, cinnolines, 1,4-dihydroquinolines, oxindoles, imidazo[1,5-α]pyridines, imidazoles, etc. The works included herein are introduced two major sections heterocycle construction carbocycle reactions, covering reported from 2012 to 2022. 1 Introduction 2 Electrochemical Cascade Cyclization Synthesis Heterocycles 2.1 Pyridines, Quinolines, Phenanthridines, Cinnolines 2.2 1,4-Dihydroquinolines, Hexacyclic Sulfonamides, Thiazines 2.3 Hydroisoquinolinones Hydroquinolinones 2.4 Quinazolin-4(3H)-ones 2.5 4H-3,1-Benzoxazines 2.6 Oxindoles 2.7 Indolines Indoles 2.8 Imidazo[1,5-α]pyridines Imidazoles 2.9 Imidazolones, Imidazolidinones, Oxazolones, Oxazolidinones 2.10 Benzoxazoles, Oxazolines, Isoxazolines 2.11 Furans Dihydrofurans 2.12 Indolizines, Pyrazoles, Triazolium Inner Salts 2.13 Sulfonated Benzothiophenes, Thiazoles, Dihydrothiazoles, 1,3,4-Thiadiazoles 2.14 Lactones 3 Construction Carbocycles 3.1 Carbon Polycycles Spiroindenes 3.2 Difluoroacyl (Hetero)arenes Indenones 4 Conclusion
Язык: Английский
Процитировано
23
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10660 - 10677
Опубликована: Июль 18, 2024
Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of
Язык: Английский
Процитировано
8
Synthesis, Год журнала: 2024, Номер 56(16), С. 2565 - 2571
Опубликована: Апрель 26, 2024
Abstract Visible-light photocatalytic reactions between enaminones and thioureas leading to thiazole products have been achieved. The annulation process consists of tandem C–S C–N bond formation by running under air atmosphere at ambient temperature. Broad substrate tolerance the sustainable protocol has verified practical synthesis divergent thiazoles with both monocyclic fused cyclic structures.
Язык: Английский
Процитировано
5
Green Chemistry, Год журнала: 2024, Номер 26(15), С. 8706 - 8710
Опубликована: Янв. 1, 2024
We report an electrochemical strategy for N -sulfonylation of azoles with sulfonyl hydrazides via radical–radical cross-coupling.
Язык: Английский
Процитировано
5
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 8257 - 8267
Опубликована: Июнь 1, 2023
Photocatalytic benzylic C–H oxidation/cyclization of enaminones was efficiently achieved to afford oxazole derivatives under mild conditions. The oxygen in the ring originated from green oxidant molecular oxygen. synthetic protocol features broad substrate scopes and good functional group tolerance. combined experimental theoretical studies reveal that suit is involved reaction transformations.
Язык: Английский
Процитировано
12
Mini-Reviews in Medicinal Chemistry, Год журнала: 2023, Номер 24(8), С. 793 - 843
Опубликована: Сен. 14, 2023
Heterocyclic derivatives serve as the fundamental components of both natural and synthetic drugs. Enaminones play a crucial role foundational units in synthesis numerous bioactive heterocyclic compounds, including pyrazoles, pyridines, oxazoles, isoxazoles, well fused structures like indoles, carbazoles, quinolines, acridines, phenanthridines. These diverse rings are well-known for their various therapeutic activities, encompassing anticancer, anti-inflammatory, antimicrobial, antidepressant, antiviral properties. By reacting with nitrogenbased nucleophiles, enaminones can generate azoles, azines, systems. This study focuses on recent advancements enaminone reactions (a) nitrogen-based such aliphatic amines, aniline, hydroxylamine, hydrazine derivatives, guanidine urea, thiourea (b) electrophiles, diazonium salts. have led to wide range compounds from 2010 end 2022.
Язык: Английский
Процитировано
11
Green Chemistry, Год журнала: 2023, Номер 25(24), С. 10144 - 10181
Опубликована: Янв. 1, 2023
The electrochemical cascade process majorly satisfies the essential criteria of green synthesis. Being an Integrated synthetic strategy it can produce more molecules in a shorter time and thus provides modern strategic tool arsenal chemists.
Язык: Английский
Процитировано
11
Green Synthesis and Catalysis, Год журнала: 2023, Номер unknown
Опубликована: Окт. 1, 2023
The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence a halogen source is realized at room temperature. work provides tunable efficient accesses to 4-chloro- 4-bromopyrazoles aqueous THF (tetrahydrofuran) without using any transition metal reagent.
Язык: Английский
Процитировано
10