Electrochemical Enaminone-Thioamide Annulation and Thioamide Dimeric Annulation for the Tunable Synthesis of Thiazoles and 1,2,4-Thiadiazole

Organic Letters, Год журнала: 2024, Номер 26(25), С. 5263 - 5268

Опубликована: Июнь 14, 2024

A green and sustainable electrochemical oxidative cyclization of enaminones with thioamides under metal- oxidant-free conditions has been developed, providing an efficient approach for thiazole synthesis. Furthermore, 1,2,4-thiadiazoles can be selectively accessed via the dimerization in absence enaminones.

Язык: Английский

---

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(8)

Опубликована: Июль 20, 2023

Abstract In terms of pharmaceuticals and biological applications, synthesis complex organic molecules is a significant fast‐developing area. this context, electrosynthesis an alternative way to the traditional methods for chemo‐, regio‐, stereoselective syntheses. Electro‐organic reactions occur at room temperature normal pressure, through transferring electrons. It has been found that mild approach preparing electrophilic substrates, bases, nucleophiles in situ , from highly stable low‐level reagents; which can be further applied make heterocycles more accessible. While several promising exist, multi‐component (MCRs) have drawn much attention both academia industry worldwide, since they are cost‐efficient environmentally friendly. Combining MCRs produced great strategy field research. This review focuses on recent advances electrochemical heterocyclic compounds via reactions, reported between 2015 March 2023.

Язык: Английский

---

Electrochemical difunctionalization of alkenes and alkynes for the synthesis of organochalcogens involving C–S/Se bond formation

Organic Chemistry Frontiers, Год журнала: 2023, Номер 11(2), С. 597 - 630

Опубликована: Ноя. 23, 2023

This review highlights the recent progress in electrochemical difunctionalization of alkenes and alkynes involving C–S/Se bond formation to access organochalcogen frameworks.

Язык: Английский

---

Recent Advances in Cyclization Reactions of 1,6‐Enynes

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(6), С. 1220 - 1268

Опубликована: Янв. 22, 2024

Abstract Elaborated molecular architectures, specifically those bearing one or more carbon stereocenters, stand as an important class of carbocyclic and heterocyclic frameworks because they are frequently occurring core structures in numerous natural products biologically active pharmaceutical molecules. Over the past few decades, development versatile synthetic approaches via cascade cyclization reactions 1,6‐enynes for construction a series fused spiro compounds has been focus great deal research initiatives. These synthesis strategies peculiarly fascinating context assembly wide array molecules, products, agrochemicals, functional materials. In this review, recent developments transformations with diverse coupling reagents summarized since 2018, which could be divided into five categories: 1) Introduction; 2) Transition metal catalyzed 1,6‐enynes; 3) Metal‐free 4) Visible‐light‐induced 5) Electrocatalytic 1,6‐enynes.

Язык: Английский

---

Electrochemical Sulfonylation/Cyclization of N-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10660 - 10677

Опубликована: Июль 18, 2024

Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of

Язык: Английский

---

Recent advances on electrochemical generation of sulfonyl radical triggered cyclization of alkene/alkynes

Tetrahedron, Год журнала: 2025, Номер 173, С. 134467 - 134467

Опубликована: Янв. 12, 2025

Язык: Английский

---

Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides

Chemical Science, Год журнала: 2024, Номер 15(8), С. 2827 - 2832

Опубликована: Янв. 1, 2024

Efficient control over several possible reaction pathways of free radicals is the chemical basis their highly selective transformations. Among various competing pathways, sulfonimidyl generated from electrolysis 2-alkynylbenzenesulfonamides undergo cascade migratory or

Язык: Английский

---

Photocatalytic synthesis of dual acylmethylation derivates of indole[2,1-a]isoquinolinones via tandem cyclization/C3 acyl methylation

Molecular Catalysis, Год журнала: 2025, Номер 580, С. 115058 - 115058

Опубликована: Апрель 15, 2025

Язык: Английский

---

Electrochemical Cascade Reactions of 1,2,3-Benzotriazinones with Alkynes to Assemble 3,4-Dihydroisoquinolin-1(2H)-ones

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

An unexpected electrochemical cascade reaction of 1,2,3-benzotriazinones with alkynes to assemble 3,4-dihydroisoquinolin-1(2H)-ones has been developed, which avoids the use pressurized H2, any metal catalysts, and stoichiometric redox agents. This route tolerates a wide range functional groups in both reactants can be performed under an air atmosphere. The process continuous cathodic reduction was demonstrated by control experiments cyclic voltammograms. Moreover, gram-scale confirmed potential this environmentally benign method for practical applications.

Язык: Английский

---

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(25), С. 5052 - 5086

Опубликована: Янв. 1, 2024

1,2/1,1-Difunctionalization of alkynes (cascade C–C and C–O bond formations) serves as one the reliable methods for synthesis numerous chemical architectures.

Язык: Английский

---