The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(18), С. 13678 - 13690
Опубликована: Сен. 6, 2024
Herein,
a
visible-light-promoted
radical
cascade
cyclization
of
heterocyclic
ketene
aminals
(HKAs)
and
thiocyanates
was
developed
to
access
functionalized
fused
2-iminothiazolines.
This
novel
reaction
can
be
realized
under
only
visible-light
irradiation
without
the
help
external
photocatalysts,
oxidants,
additives.
These
multicomponent
reactions
demonstrate
excellent
selectivity
for
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2433 - 2442
Опубликована: Фев. 8, 2023
A
simple
and
concise
method
for
the
synthesis
of
cinnolines
has
been
developed
by
reactions
readily
available
enaminones
aryl
diazonium
tetrafluoroboronates.
The
run
efficiently
to
provide
with
broad
diversity
in
substructure
heating
dimethyl
sulfoxide
without
using
any
catalyst
or
additive.
In
addition,
primary
investigation
anti-inflammatory
activity
these
products
leads
observation
p-chlorobenzoyl
(3f)
p-nitrobenzoyl
(3j)
as
attractive
compounds
vitro.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
A
tandem
Hexadehydro-Diels–Alder
(HDDA)/[2
+
2]
cycloaddition/aryl
migration
reaction
of
iodonium
ylide
with
tetrayne
is
described,
in
which
served
as
a
unique
double
bond
and
reacted
aryne
to
form
four-membered
iodonium(III)
cycle,
then
converted
iodoarene
after
aryl
group
from
iodine
adjacent
carbon.
This
strategy
allows
the
efficient
construction
fully
substituted
compounds.
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(17), С. 1504 - 1530
Опубликована: Сен. 1, 2023
Abstract:
Dess-Martin
periodinane
(DMP)
is
one
of
the
hypervalent
iodines
that
most
frequently
utilized
as
an
oxidizing
agent
in
organic
chemistry.
The
authors
this
septennial
review
have
critically
and
methodically
presented
representative
applications
DMP
synthesis
from
2015
to
present,
including
oxidations,
dehydrogenations,
hetero
homo-dimerizations,
aromatizations,
thiocyanations,
halogenations,
dearylations,
ring
expansions,
cyclizations,
heterocyclic
formation,
other
miscellaneous
reactions.
This
discusses
range
constraints
these
transformations.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(8), С. 5266 - 5276
Опубликована: Апрель 9, 2024
A
transition
metal-free
concise
and
efficient
protocol
for
the
synthesis
of
thiocyanated
aminomaleimides
benzo[e][1,4]thiazepine
derivatives
has
been
developed.
The
method
involves
an
initial
α-C–H
thiocyanation
with
KSCN
TEMPO-mediated
tandem
S–CN
bond
cleavage/intramolecular
cyclization
substitution
processes,
which
enables
formation
seven-membered
S/N-heterocycles.
This
synthetic
strategy
provides
a
reliable
biologically
interesting
by
using
as
sulfur
sources
well
expands
application
enaminones
reactions
in
heterocycles
synthesis.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 25, 2024
Abstract
We
describe
a
selective
preparation
of
variety
functionalized
pyrrolo[2,3‐
c
]tetrahydroquinolines
and
indolo[3,2‐
in
40–82%
40–80%
yields
from
alkynyl‐tethered
oximes
with
diaryliodonium
triflates,
respectively.
The
one‐pot
reaction
underwent
N
‐arylation,
intramolecular
[3+2]
cycloaddition,
[1.3]
or
[3,3]‐rearrangement
N−O
bond
total
three
steps.
Experimental
studies
revealed
that
EtOAc
solvent
copper(II)‐catalyst
played
crucial
roles
on
the
formation
these
two
tetrahydroquinoline
scaffolds.
Moreover,
scaffolds
could
be
converted
into
various
building
blocks
by
further
transformations.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(39)
Опубликована: Авг. 25, 2023
Abstract
An
efficient
three‐component
synthesis
of
4‐aryl‐2‐aminothiazoles
was
reported.
Phenyl‐thioureas
reacted
with
2‐bromoacetophenones
to
form
through
cyclization,
and
the
subsequent
C−N
bonding
benzyl/allyl
bromides
gave
desired
disubstituted
thiazoles
smoothly.
The
protocol
features
transition‐metal
free,
short
reaction
time,
easily
available
starting
materials,
good
yields
broad
substrate
scope,
showing
potential
synthetic
value
for
a
variety
biologically
or
pharmaceutically
active
compounds.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(48), С. 9524 - 9529
Опубликована: Янв. 1, 2023
An
eco-friendly
and
metal-free
method
for
the
synthesis
of
tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones
was
established.
Quinoline-derived
dipolarophiles
cyclic
enaminones
as
starting
materials
undergo
a
1,4-Michael
addition/SNAr
tandem
annulation
reaction
affording
target
products.
This
approach
features
transition
conditions,
good
functional
group
tolerance
operational
simplicity.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry,
Год журнала:
2023,
Номер
22(3), С. 133 - 163
Опубликована: Сен. 1, 2023
Abstract:
The
thiazole
ring
is
a
unique
heterocyclic
motif
among
compounds.
This
five-member
with
one
nitrogen
and
sulphur
atom
displays
wide
array
of
pharmacological
activities,
including
anti-inflammatory,
antimicrobial,
anticancer,
antidiabetic,
antiviral,
etc.,
by
acting
on
several
targets.
Its
broad
range
medical
applications
has
inspired
us
to
study
this
opulent
molecule.
current
review
summarizes
synthetic
approaches
for
the
preparation
derivatives
in
brief
discusses
promising
biological
activities
scaffold.
will
be
useful
drug
discovery
community
facilitate
synthesis
development
novel
potent
derivatives,
which
may
serve
as
lead
molecules
treatment
various
diseases.
