The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Alcohols
are
the
most
commercially
abundant,
synthetically
versatile
and
operationally
convenient
functional
groups
in
organic
chemistry.
Therefore,
a
strategy
that
utilizes
hydroxy-containing
compounds
to
develop
novel
bond
disconnection
formation
process
would
achieve
molecular
diversity.
Herein,
deconstructive
for
generation
of
quinoxalin-2(1H)-one
derivatives
has
been
developed
from
alcohol
precursors
via
oxy-radical-induced
β-fragmentation.
Additionally,
1,5-HAT
deoxygenation
by
P(III)
along
with
oxy-radical
were
demonstrated
as
alternative
pathways
this
transformation.
Furthermore,
deep-seated
reorganization
few
terpenes
carbon
framework,
unique
activity
inhibition
against
growth
pathogenic
fungi
was
observed.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(18), С. 13339 - 13350
Опубликована: Авг. 31, 2023
We
report
a
metal-
and
photocatalyst-free
C3
α-aminomethylation
of
quinoxalin-2(1H)-ones
with
N-alkyl-N-methylanilines.
The
reaction
proceeds
through
the
formation
photoactivated
electron
donor–acceptor
complex
between
present
method
provides
mild
environmentally
friendly
protocol
that
exhibits
good
atom
economy
excellent
functional
group
tolerance
to
obtain
library
biologically
significant
α-aminomethylated
in
yields.
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(14), С. 6095 - 6102
Опубликована: Янв. 1, 2024
A
new
copper(
ii
)
bromide/
N
-methylmorpholine
-oxide
(NMO)-promoted
method
for
α-amination
of
esters
under
continuous-flow
conditions,
with
reduced
catalyst
loading
is
reported.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(9), С. 6169 - 6179
Опубликована: Апрель 24, 2024
An
efficient
2,2,6,6-tetramethylpiperidinooxy
(TEMPO)-mediated
hydroxyfluoroalkylation
of
arylamines
with
polyfluorinated
alcohols
via
a
radical-triggered
C(sp
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(29), С. 20425 - 20431
Опубликована: Июль 8, 2024
p-Diarylboryl
halothiophenols
are
developed
and
unequivocally
characterized.
Their
photophysical
properties
catalytic
performance
unveiled
by
experimental
theoretical
investigations.
This
novel
class
of
triarylboranes
behaves
as
a
Brønsted
acid
to
generate
the
corresponding
borylthiophenolate
that
can
absorb
visible
light
undergo
intramolecular
charge
transfer
form
radical
pair
consisting
boron
anion
thiyl
radical,
which
acts
single-electron
reductant
while
engaging
in
hydrogen
atom
regenerate
parent
borylthiophenol.
The
synthetic
relevance
this
mode
action
is
demonstrated
establishment
unique
catalysis
integrates
three
different
yet
tunable
functions
single
cycle,
thereby
allowing
borylthiophenols
solely
promote
assembly
sterically
congested
1,2-diols
1,2-aminoalcohol
derivatives
via
radical–radical
cross-coupling.
RSC Advances,
Год журнала:
2025,
Номер
15(20), С. 16183 - 16186
Опубликована: Янв. 1, 2025
An
efficient
radical
alkylative
annulation/arylation
of
N
-(arylsulfonyl)acrylamide
with
4-alkyl-1,4-dihydropyridines
(DHP)
was
developed
for
synthesizing
all-carbon
quaternary-centered
β-alkyl
amides.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(27)
Опубликована: Июнь 8, 2023
Abstract
Heterocyclics
are
the
crucial
scaffolds
present
in
pharmaceuticals,
natural
products,
biologically
active
compounds
and
agrochemicals.
Consequently,
development
of
simple
practical
methods
for
constructing
heterocyclics
has
always
been
a
fascinating
field
organic
synthesis.
Recently,
2‐acylbenzoic
acids,
highly
reactive
versatile
synthons,
have
broadly
applied
construction
heterocycles
due
to
their
multiple
reaction
sites.
In
this
review,
we
summarized
recent
progress
application
acids
synthesis
including
phthalides,
isochromanones,
isoindolines,
phthalazinones,
quinolones.
The
substrate
scopes,
proposed
mechanisms,
product
different
types
reactions
discussed.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(68)
Опубликована: Авг. 28, 2024
The
visible
light-induced
decarboxylative
cascade
reaction
of
fluoroalkyl
carboxylic
acids
has
been
achieved
for
the
efficient
synthesis
fluorinated
compounds.
However,
most
transformations
rely
on
noble
iridium
metal
complex.
Herein,
a
metal-free
realized.
This
protocol
features
simple
operation,
transition
free,
and
good
functional
group
tolerance.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(21), С. 15326 - 15334
Опубликована: Окт. 25, 2023
A
mild
late-stage
modification
of
pyrrolo[2,1-a]isoquinolines
was
established
through
iron-catalyzed
oxidative
dearomatization
and
peroxidation.
Peroxylated
pyrroloisoquinolines
have
been
prepared
readily
with
hydroperoxide
in
low
to
good
yields
(up
72%)
at
room
temperature.
Interestingly,
the
treatment
fully
aromatized
pyrrolo[1,2-a]quinolines
under
current
reaction
system
resulted
formation
ring-opening
products.
Catalysts,
Год журнала:
2023,
Номер
13(12), С. 1502 - 1502
Опубликована: Дек. 8, 2023
The
glycine
motif
is
widely
prevalent
in
bioactive
peptides.
Thus,
the
direct
and
precise
modification
of
derivatives
has
attracted
significant
attention
over
past
few
decades.
Among
various
protocols
for
derivatives,
visible-light-driven
α-C(sp3)–H
bond
functionalization
emerged
as
a
powerful
tool
to
achieve
this
objective,
owing
its
merits
atom
economy,
selectivity,
reaction
simplicity,
sustainability.
This
review
summarizes
recent
advancements
derivatives.
contents
are
organized
based
on
photocatalysts
employed
modes
process.
mechanism,
challenges
encountered,
future
trends
also
discussed,
enabling
readers
understand
current
developmental
status
field.
