Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(3)
Опубликована: Окт. 25, 2023
Initiated
by
triarylamine
radical
cation
salt
(TBPA),
the
direct
C-H
bond
functionalization
of
α-N-aryltetrahydroisoquinoline
esters
was
smoothly
realized,
giving
a
series
α-hydroxylated
derivatives
with
quaternary
carbon
center
in
good
yields.
Differently,
presence
tert-butyl
nitrite
(TBN),
C-N
single
cleaved
to
keto
esters.
The
mechanistic
study
revealed
that
these
reactions
were
mediated
similar
mechanism,
which
N-nitrosation
might
provide
driving
force
cleavage.
Organic Letters,
Год журнала:
2023,
Номер
25(32), С. 6001 - 6005
Опубликована: Авг. 7, 2023
An
electrochemical
facilitated
three-component
trifluoromethylation/spirocyclization
reaction
of
N-(arylsulfonyl)acrylamides,
CF3SO2Na,
and
H2O
has
been
developed.
Without
the
requirement
chemical
oxidants,
a
number
unexplored
trifluoromethylated
4-azaspiro[4.5]decanes
were
obtained
in
satisfactory
yields
under
mild
conditions.
This
work
provides
new
synthetic
strategy
for
fluorine-containing
spirocyclic
compounds
shows
perspective
reactivity
study
N-(arylsulfonyl)acrylamides.
Beilstein Journal of Organic Chemistry,
Год журнала:
2025,
Номер
21, С. 155 - 178
Опубликована: Янв. 16, 2025
In
recent
decades,
organic
electrosynthesis
has
emerged
as
a
practical,
sustainable,
and
efficient
approach
that
facilitates
valuable
transformations
in
synthetic
chemistry.
Combining
electrochemistry
with
transition-metal
catalysis
is
promising
rapidly
growing
methodology
for
effectively
forming
challenging
C-C
C-heteroatom
bonds
complex
molecules
sustainable
manner.
this
review,
we
summarize
the
advances
combination
of
copper
various
transformations.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(22), С. 4390 - 4419
Опубликована: Янв. 1, 2024
The
merger
of
organic
electrosynthesis
with
3d
transition-metal
catalysis
has
offered
huge
opportunities
for
modern
synthesis.
This
review
summarizes
the
key
advancements
in
this
direction
published
recent
two
years.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(12), С. 2829 - 2834
Опубликована: Апрель 24, 2024
Abstract
A
strategy
for
the
synthesis
of
N,N
‐disubstituted
hydrazines
via
electrocatalytic
addition
hydrazine
to
α,β‐unsaturated
carbonyl
compounds
is
reported.
The
reaction
was
carried
out
under
constant
current
electrolytic
conditions
in
an
undivided
cell.
Using
this
methodology,
various
were
prepared
57–94%
yield
40
minutes.
By
adding
cyclohexanone
and
acetic
acid
mixture
heating
2
hours,
a
one‐pot
N
‐substituted
indoles
also
developed.
Furthermore,
based
on
cyclic
voltammetry
control
experiments,
plausible
mechanism
involving
radical
pathway
proposed.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(20), С. 3455 - 3460
Опубликована: Авг. 24, 2023
Abstract
An
electrochemically‐driven
organocatalytic
enantioselective
oxidative
coupling
of
tetrahydroisoquinolines
and
acrylaldehyde
was
developed.
Various
chiral
C1‐alkenyl
derivatives
were
obtained
with
69–86%
yields
93:7–96:4
er.
Notable
features
this
reaction
include
asymmetric
organocatalysis
(5.0
mol%
β‐ICD
as
catalyst),
electricity
the
oxidant,
air
atmosphere,
undivided
cell.
This
synthetic
route
offers
access
to
various
optically
active
C1‐substituted
derivatives.
