Abstract
Phenylhydrazines,
comprised
of
a
phenyl
group
attached
with
hydrazine
unit,
contribute
potentially
to
organic
synthetic
transformations.
Because
the
myriad
applications,
last
decade
has
witnessed
considerable
upsurge
interest
perform
various
reactions
catalyzed/mediated/promoted
by
phenylhydrazines.
Some
these
have
shown
high
regioselectivity
in
short
reaction
time
under
mild
conditions.
The
emergence
innumerable
transformations
utilizing
phenylhydrazine
unleashed
numerous
openings
for
development
diverse
heterocyclic
scaffolds.
Given
importance
this
valuable
chemical
entity,
review
highlights
methodologies
Moreover,
present
article
will
considerably
synthesis
as
well
pharmaceutical
chemistry.
Academically,
be
interesting
and
informative
researchers
attempting
develop
new
routes
structures.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2505 - 2515
Опубликована: Фев. 5, 2024
A
novel
iodine-promoted
difunctionalization
of
α-C
sites
in
enaminones
was
demonstrated
as
a
means
synthesizing
variety
fully
substituted
thiazoles
by
constructing
C–C(CO),
C–S,
and
C–N
bonds.
This
transformation
allows
the
realization
unusual
aryl
C2
synthons
simultaneously
thioylation
dicarbonylation
sites.
preliminary
mechanistic
study
performed
indicated
that
cleavage
C═C
bonds
involves
bicyclization/ring-opening
oxidative
coupling
sequence.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Pyrazole
moiety
is
considered
as
an
important
N-heterocycle
in
pharmaceuticals
and
many
other
functional
molecules.
The
utilization
of
multicomponent
reaction
a
major
tool
the
current
approaches
pyrazole
synthesis.
Considering
power
significance
synthesis,
we
review
herein
latest
developments
this
field.
According
to
typical
features,
contents
are
divided
into
reactions
with
different
NN
fragment
sources,
such
hydrazine,
hydrazone,
amidine,
nitrile,
diazo
compounds,
ring
construction,
covering
works
published
since
2019
date.
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Green Synthesis and Catalysis,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 1, 2023
The
synthesis
of
4-halo-functionalized
pyrazoles
by
electrochemical
cascade
reactions
between
N,N-dimethyl
enaminones
and
proper
hydrazine
reagents
in
the
presence
a
halogen
source
is
realized
at
room
temperature.
work
provides
tunable
efficient
accesses
to
4-chloro-
4-bromopyrazoles
aqueous
THF
(tetrahydrofuran)
without
using
any
transition
metal
reagent.
Synthetic Communications,
Год журнала:
2024,
Номер
54(6), С. 491 - 503
Опубликована: Фев. 10, 2024
By
using
easily
accessible
heterocyclic
enamines,
acetaldehyde
(or
formaldehyde)
and
primary
amines
as
suitable
precursors,
a
water-assisted
three-component
synthesis
of
new
3-oxothiazolo[3,2-c]pyridimines
has
been
efficiently
achieved
in
mild
semi-aqueous
medium.
All
the
cyclization
reactions
under
optimized
catalyst-free
conditions
furnish
target
compounds
40–100%
yields.
Although
cyclizations
with
arylamines
presence
formaldehyde
yield
moderate
to
good
yields,
certain
involving
aryl
do
not
result
any
product
formation.
Structural
characterization
all
products
were
performed
by
means
FT-IR,1H
13C
NMR
HRMS
analyses.
Besides,
some
demonstrated
bacteriostatic
effects
antibacterial
study
conducted
against
S.
aureus
epidermidis
bacteria.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(18), С. 10218 - 10226
Опубликована: Апрель 26, 2024
In
this
work,
a
series
of
pyrrolidinone-containing
2-phenylpyridine
derivatives
were
synthesized
and
evaluated
as
novel
protoporphyrinogen
IX
oxidase
(PPO,
EC
1.3.3.4)
inhibitors
for
herbicide
development.
At
150
g
ai/ha,
compounds
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
