Organic Preparations and Procedures International, Год журнала: 2024, Номер unknown, С. 1 - 10
Опубликована: Ноя. 15, 2024
Язык: Английский
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(10), С. 2363 - 2369
Опубликована: Март 16, 2024
Abstract A synthetic protocol was developed to synthesize highly functionalized 3‐furylmethyl chromones from enynones and o ‐hydroxyphenyl enaminones via silver‐catalyzed cascade bis‐heteroannulation reaction. This strategy features broad substrate scope good functional group tolerance. Furthermore, the chromone skeleton shows potential application value through further gram‐scale synthesis derivatization.
Язык: Английский
Процитировано
13
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8521 - 8530
Опубликована: Июнь 3, 2024
An oxidative free-radical C(sp2)–H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K2S2O8 an oxidant. This transformation provides new straightforward synthetic methodology to afford highly functionalized α-chlorinated with Z-configuration in good excellent yields.
Язык: Английский
Процитировано
6
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 9078 - 9085
Опубликована: Июнь 3, 2024
The α-C–H trifluoromethylthiolation of N,N-disubstituted enaminones has been achieved with simple and cheap CF3SO2Na as the CF3S source. reactions were run at mild temperature (0 °C to rt) using POCl3 only reducing reagent. work represents first example on synthesis α-trifluoromethylthio via direct C–H functionalization. In addition, resulting CF3S-functionalized have proven useful building blocks in various heteroaromatic compounds by annulation reactions.
Язык: Английский
Процитировано
6
Tetrahedron Letters, Год журнала: 2025, Номер 158, С. 155472 - 155472
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
0
Topics in Current Chemistry, Год журнала: 2023, Номер 381(5)
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
7
ChemCatChem, Год журнала: 2024, Номер unknown
Опубликована: Май 27, 2024
Abstract Nitrogen‐containing heterocycles represent fundamental components found in a myriad of natural compounds, pharmaceuticals, tailored bioactive substances, and agrochemicals. In recent decades, the field synthetic chemistry has prioritized these directing considerable research endeavour toward developing efficient concise methodologies for their synthesis. Consequently, there is growing interest pioneering novel approaches to fabricate immensely coveted structural motifs. Transition metal‐catalyzed reactions leveraging solvents as carbon (C1) synthons offer notable advantages, including streamlined processes, enhanced atom economy, environmental sustainability. This review sheds light on advancements utilization collective such methanol (alongside other alcohols), N,N ‐dimethylethanolamine (DMEA), triethylamine (TEA) (in conjunction with amines), tetrahydrofuran (THF), toluene, dichloromethane (DCM), dimethyl sulfoxide (DMSO), dimethylformamide (DMF) C1 synthons, serving foundational units synthesis N ‐heterocycles, quinazolinone, quinazoline, quinoxaline, pyridine, pyrimidine, among others. Various reaction conditions employing diverse transition metals, coupling partners, or reagents, reported literature, have been explored.
Язык: Английский
Процитировано
2
Current Organic Chemistry, Год журнала: 2024, Номер 28(20), С. 1593 - 1604
Опубликована: Июль 12, 2024
: This study outlines the development of a novel approach utilizing microwave assistance for alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt in conjunction with chroman-4-one amino ligands. research introduces unique catalytic system capable synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, coumarins via dehydrogenation. synthesis involved preparation characterization series chroman- 4-one ligands (C1-C6) using standard analytical techniques. These ligands, combination MnCl2‧4H2O CoCl2, demonstrated remarkable activity, effectively driving cycle was initiated in-situ formation metal complexes during Characterization ESI-MS confirmed presence (Int-1) other intermediates (Int-II Int-III) throughout cycle. Additionally, controlled experiment corroborated efficacy system, evidenced evolution H2 gas.
Язык: Английский
Процитировано
1
ChemistrySelect, Год журнала: 2024, Номер 9(28)
Опубликована: Июль 23, 2024
Abstract The synthesis of 2‐amino‐1,4‐dihydropyridines was accomplished starting from β‐enaminones, aromatic aldehydes and malononitrile with DBU without solvent. reaction proceeds through a Knoevenegel condensation, which affords the benzylidine olefin intermediate. This can directly react β‐enaminone, leading to desired product. Simple conditions no solvent good yields are advantages this protocol.
Язык: Английский
Процитировано
0
Asian Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Окт. 16, 2024
Abstract The use of C−H compounds as reactive partners in a variety transformations represents the state art synthetic methodology. In this review, we have summarized main achievements using ethers building blocks for construction and modification one basic platforms organic chemistry, nitrogen‐containing heterocycles. Ethers, previously considered mainly solvents, are excellent CH‐partners, capable generating radical or cationic species under action HAT agents oxidants. challenge field is still limited number heterocyclic systems other starting reagents, with which processes can be carried out selectively due to closer bond dissociation energies oxidation potentials heterocycles, intermediates ethers. However, fine‐tuning reaction system electro‐ photochemical approaches deep understanding pathways make reagents promising strategy.
Язык: Английский
Процитировано
0
Organic Preparations and Procedures International, Год журнала: 2024, Номер unknown, С. 1 - 10
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
0