Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis propiophenones and their application in 3-methyl chromone synthesis DOI

Zhi Tu,

Jie‐Ping Wan, Wei Li

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A method of reducing

Язык: Английский

Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates DOI
Cong Ma, Long Yin Lam

Synthesis, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or derivatives, which are associated with unpleasant odors potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl oxyacids, sulfoxides, thiol surrogates for thioether synthesis. This review highlights recent advancements deoxygenative synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, hydro/halo/oxy-thiolation unsaturated hydrocarbons. We also discuss representative mechanisms to provide comprehensive understanding these innovative approaches. 1 Introduction 2 Cross-Coupling Reactions 3 Functionalization 4 Hydro/Halo/Oxy-thiolation Unsaturated Hydrocarbons 5 Conclusion

Язык: Английский

Процитировано

1

Synthesis of Multisubstituted Arylnitriles via Tf2O-Mediated Benzannulation of Enaminones with Acylacetonitriles DOI
Xiaohan Zhang,

Fang Li,

Yue Zhou

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

A novel and efficient method for the synthesis of multisubstituted arylnitriles via Tf2O-mediated [3 + 2 1] benzannulation enaminones acylacetonitriles has been developed. This reaction proceeds under mild conditions with excellent functional group compatibility. Mechanistic studies have revealed that cyclization involves two consecutive nucleophilic additions, followed by a cascade Knoevenagel condensation aromatization. Additionally, trifluoromethanesulfonate 6 identified as crucial intermediate in this process.

Язык: Английский

Процитировано

1

Recent Advances in Site Selective Transformations of β-Enaminones via C-H Functionalization/Annulation DOI
Prasanta Ray Bagdi, Karuna Mahato,

Divya Shrestha

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

β-Enaminone transformation strategies are widely employed in the synthesis of numerous biologically active drugs and natural products, highlighting their significance medicinal chemistry.

Язык: Английский

Процитировано

5

Synthesis of 4-(Bromodifluoromethylseleno) Isocoumarins via Selenolation/Lactonization of 2-Alkynylbenzoates Enabled by a Multi-Component Reagents System DOI

Dongxue Yin,

Yang Wang,

Kaiyue Yang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

p-CF3BnSeCF2Br was developed as a bromodifluoromethylselenonating reagent, which utilized by combining with mCPBA and Tf2O for the synthesis of 4-(bromodifluoromethylseleno) isocoumarins via selenolation/lactonization 2-alkynylbenzoates. The transformation postulated to proceed multicomponent reagents system-enabled sequence involving oxidation into its selenium sulfoxide, activation generated sulfoxide electrophilic p-CF3BnSeOCF2Br salt, 2-alkynylbenzoates reactive species isocoumarins.

Язык: Английский

Процитировано

0

Organic Base-Catalyzed Cascade Reaction of CF3–Iminopropargylic Alcohols with Carboxylic Acids: an Approach to β-CF3 β-Aminoenones DOI
Ruslan S. Shulgin,

O. G. Volostnykh,

А. В. Степанов

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

A novel approach to the synthesis of β-CF3 β-aminoenones by organic amine base-catalyzed reaction CF3-iminopropargylic alcohols with carboxylic acids is reported. The advantages protocol are ease operation, available starting materials, and simple tertiary catalysts.

Язык: Английский

Процитировано

0

Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis propiophenones and their application in 3-methyl chromone synthesis DOI

Zhi Tu,

Jie‐Ping Wan, Wei Li

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A method of reducing

Язык: Английский

Процитировано

1