Minisci‐Type Carbamoylation of Azauracils with Oxamic Acids
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(7)
Опубликована: Янв. 19, 2024
Abstract
A
Minisci‐type
carbamoylation
of
azauracils
was
developed
to
afford
6‐carbamoyl
in
yields
up
94
%.
In
this
transformation,
oxamic
acids
were
employed
as
the
carbamoyl
radical
sources
under
metal‐free
conditions.
It
features
high
atom
economy,
good
functional
group
compatibility
and
convenient
operation.
Язык: Английский
Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(9), С. 1821 - 1833
Опубликована: Янв. 1, 2024
Metal-free
synthesis
of
medicinally
important
carbamoylated
dihydroquinolinones
using
readily
available,
cheap
and
environment-friendly
materials
with
good
to
excellent
yields.
Язык: Английский
Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones
Molecules,
Год журнала:
2024,
Номер
29(5), С. 997 - 997
Опубликована: Фев. 25, 2024
The
incorporation
of
amide
groups
into
biologically
active
molecules
has
been
proven
to
be
an
efficient
strategy
for
drug
design
and
discovery.
In
this
study,
we
present
a
simple
practical
method
the
synthesis
amide-containing
quinazolin-4(3H)-ones
under
transition-metal-free
conditions.
This
is
achieved
through
carbamoyl-radical-triggered
cascade
cyclization
N3-alkenyl-tethered
quinazolinones.
Notably,
carbamoyl
radical
generated
in
situ
from
oxidative
decarboxylative
process
oxamic
acids
presence
(NH4)2S2O8.
Язык: Английский
Photoinduced Direct Carbamoylation of Ethers with Isocyanates towards synthesis of α- Amide Substituted Ether Derivatives
Ming Qi,
Jing-Han Li,
Xiao‐Jie Lu
и другие.
Synlett,
Год журнала:
2024,
Номер
35(16), С. 1914 - 1918
Опубликована: Фев. 20, 2024
Abstract
Photoinduced
carbamoylation
of
ethers
using
isocyanates
as
amide
sources
was
accomplished
under
mild
and
environmentally
friendly
reaction
conditions.
A
series
were
tolerated
in
this
protocol
to
construct
α-amide-substituted
ether
derivatives
with
desired
yields.
The
method
featured
broad
substrate
scope
good
functional
group
tolerance,
which
could
play
an
important
role
the
construction
biological
molecules
ethers.
Язык: Английский
Generation of Carbamoyl Radicals and 3,4-Dihydroquinolin-2(1H)-ones Enabled by Iron Photoredox Catalysis
Synlett,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 16, 2024
Abstract
A
new
protocol
for
accessing
3,4-dihydroquinolin-2(1H)-ones
was
established
through
a
sequence
of
iron-catalyzed
photoredox
generation
carbamoyl
radicals
from
oxamic
acids,
addition
the
to
electron-deficient
alkenes,
intramolecular
cyclization,
and
aromatization.
The
process
is
compatible
with
variety
N-phenyloxamic
acids
monosubstituted,
1,1-disubstituted,
trisubstituted
alkenes.
Employing
cheap,
readily
available,
environmentally
benign
iron
as
catalyst,
provides
an
excellent
alternative
synthesis
3,4-dihydroquinolin-2(1H)-ones.
Язык: Английский
Visible-Light-Induced Three-Component Radical Coupling of Selenocarbamates, Enones, and Allylstannanes with Diphenyl (2,4,6-trimethylbenzoyl)phosphine Oxide
Synlett,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 20, 2023
Abstract
A
blue
LED-induced
three-component
coupling
of
a
carbamoyl
radical,
cyclic
enone,
and
allylstannane
was
developed.
The
use
LEDs
diphenyl(2,4,6-trimethylbenzoyl)phosphine
oxide
(TPO)
as
radical
initiator
permitted
the
to
proceed
with
high
chemoselectivity.
An
elucidation
mechanism
revealed
pathway
for
formation
tributyltin
from
TPO
allylstannane.
This
tandem
reaction
is
expected
be
applicable
in
natural-product
synthesis.
Язык: Английский