Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Recent years have witnessed the emergence of direct intermolecular C(sp

Язык: Английский

---

Pd-Catalyzed Difluoroalkylation of Alkenes Using Chlorodifluoroalkanes

ACS Catalysis, Год журнала: 2024, Номер unknown, С. 18499 - 18506

Опубликована: Дек. 4, 2024

Язык: Английский

---

Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Photoexcited Palladium Catalysis

JACS Au, Год журнала: 2024, Номер 4(11), С. 4223 - 4233

Опубликована: Ноя. 6, 2024

The incorporation of aromatic difluoromethyl motifs has proven to be a fruitful strategy for enhancing the therapeutic profiles modern pharmaceutical candidates. While defluorofunctionalization trifluoromethylarenes offers promising pathway toward diverse compounds, current methods are predominantly limited two-component reactions. Multicomponent cascade reactions (MCRs) involving transient radical still uncommon and highly sought after, owing their capacity rapidly generate challenging molecular structures. In this study, we present photocatalytic manifold that combines commercially available trifluoromethylarenes, feedstock dienes, various nucleophiles achieve modular defluorinative MCR. This method features mild reaction conditions broad substrate scope with excellent functional group compatibility. Furthermore, protocol enables previously unreported process editing resulting MCR adducts. Preliminary mechanistic studies support proposed photoexcited palladium catalytic cycle.

Язык: Английский

---

Recent Advances in Palladium-Catalyzed Annulations for the Synthesis of Pyrrolidines

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141010 - 141010

Опубликована: Дек. 1, 2024

Язык: Английский

---