Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Recent years have witnessed the emergence of direct intermolecular C(sp

Language: Английский

---

Pd-Catalyzed Difluoroalkylation of Alkenes Using Chlorodifluoroalkanes

ACS Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 18499 - 18506

Published: Dec. 4, 2024

Language: Английский

---

Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Photoexcited Palladium Catalysis

JACS Au, Journal Year: 2024, Volume and Issue: 4(11), P. 4223 - 4233

Published: Nov. 6, 2024

The incorporation of aromatic difluoromethyl motifs has proven to be a fruitful strategy for enhancing the therapeutic profiles modern pharmaceutical candidates. While defluorofunctionalization trifluoromethylarenes offers promising pathway toward diverse compounds, current methods are predominantly limited two-component reactions. Multicomponent cascade reactions (MCRs) involving transient radical still uncommon and highly sought after, owing their capacity rapidly generate challenging molecular structures. In this study, we present photocatalytic manifold that combines commercially available trifluoromethylarenes, feedstock dienes, various nucleophiles achieve modular defluorinative MCR. This method features mild reaction conditions broad substrate scope with excellent functional group compatibility. Furthermore, protocol enables previously unreported process editing resulting MCR adducts. Preliminary mechanistic studies support proposed photoexcited palladium catalytic cycle.

Language: Английский

---

Recent Advances in Palladium-Catalyzed Annulations for the Synthesis of Pyrrolidines

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141010 - 141010

Published: Dec. 1, 2024

Language: Английский

---