Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(4), С. 100827 - 100827
Опубликована: Июль 1, 2023
Nano-targeted
delivery
systems
have
been
widely
used
for
breast
tumor
drug
delivery.
Estrogen
receptors
are
considered
to
be
significant
target
due
their
overexpression
in
a
variety
of
cells.
However,
targeted
ligands
impact
on
the
safety
and
effectiveness
active
systems,
limiting
clinical
transformation
nanoparticles.
Phytoestrogens
shown
good
biosafety
characteristics
some
affinity
with
estrogen
receptor.
In
present
study,
molecular
docking
was
select
tanshinone
IIA
(Tan
IIA)
among
phytoestrogens
as
ligand
nanodelivery
modifications.
Modified
Tan
(Tan-NH2)
showed
profile
demonstrated
tumor-targeting,
anti-tumor
metastasis
effects.
Moreover,
utilized
Dox-loaded
mesoporous
silica
nanoparticles
via
chemical
modification
generate
nanocomposite
Tan-Dox-MSN.
Tan-Dox-MSN
had
uniform
particle
size,
dispersibility
high
loading
capacity.
Validation
experiments
vivo
vitro
that
it
also
better
targeting
ability,
effect
lower
toxicity
normal
organs.
These
results
supported
idea
receptor
could
improve
therapeutic
efficacy
nano-targeted
tumors.
Acta Neuropathologica Communications,
Год журнала:
2025,
Номер
13(1)
Опубликована: Апрель 19, 2025
Breast
cancer
is
one
of
the
leading
causes
death
worldwide.
The
aggressive
behaviour
breast
tumor
results
from
their
metastasis.
Notably,
brain
tissue
common
regions
metastasis,
thereby
reducing
overall
survival
patients.
Moreover,
metastatic
tumors
demonstrate
poor
response
or
resistance
to
therapies.
In
addition,
metastasis
provides
prognosis
Therefore,
it
importance
understand
mechanisms
in
Both
cell
lines
and
animal
models
have
been
developed
for
evaluation
different
microenvironment
components
other
factors
such
as
lymphocytes
astrocytes
can
affect
cells
disrupt
blood-brain
barrier
(BBB)
during
into
brain,
developing
blood-tumor
enhance
carcinogenesis.
be
increased
by
dysregulation
chemokines,
STAT3,
Wnt,
Notch
PI3K/Akt.
On
hand,
effective
therapeutics
introduction
nanoparticles.
disruption
BBB
ultrasound
increase
entrance
bioactive
compounds
tissue.
order
improve
specificity
selectivity,
nanoparticles
delivery
crossing
over
suppress
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(37), С. 7384 - 7396
Опубликована: Янв. 1, 2022
This
review
comprehensively
covers
the
extraction,
characterization,
functionalization
and
biomedical
applications
of
bacterial
outer
membrane
vesicles
(OMVs).
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(4), С. 100827 - 100827
Опубликована: Июль 1, 2023
Nano-targeted
delivery
systems
have
been
widely
used
for
breast
tumor
drug
delivery.
Estrogen
receptors
are
considered
to
be
significant
target
due
their
overexpression
in
a
variety
of
cells.
However,
targeted
ligands
impact
on
the
safety
and
effectiveness
active
systems,
limiting
clinical
transformation
nanoparticles.
Phytoestrogens
shown
good
biosafety
characteristics
some
affinity
with
estrogen
receptor.
In
present
study,
molecular
docking
was
select
tanshinone
IIA
(Tan
IIA)
among
phytoestrogens
as
ligand
nanodelivery
modifications.
Modified
Tan
(Tan-NH2)
showed
profile
demonstrated
tumor-targeting,
anti-tumor
metastasis
effects.
Moreover,
utilized
Dox-loaded
mesoporous
silica
nanoparticles
via
chemical
modification
generate
nanocomposite
Tan-Dox-MSN.
Tan-Dox-MSN
had
uniform
particle
size,
dispersibility
high
loading
capacity.
Validation
experiments
vivo
vitro
that
it
also
better
targeting
ability,
effect
lower
toxicity
normal
organs.
These
results
supported
idea
receptor
could
improve
therapeutic
efficacy
nano-targeted
tumors.
