Nanomaterials for brain metastasis DOI
Zhenhao Zhao, Yun Chen, Tao Sun

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 833 - 847

Published: Dec. 16, 2023

Language: Английский

Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier DOI Creative Commons
Qiyu Tang, Zhao Guo, Hong Fang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2786 - 2789

Published: March 20, 2024

The current status of clinical trials utilizing nanoparticle drug delivery system (NDDS) for brain tumors was summarized.Image 1.

Language: Английский

Citations

3
To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges DOI Creative Commons
Antonia Wehn,

Eva Krestel,

Biyan Nathanael Harapan

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 216 - 236

Published: May 31, 2024

Nanoparticles have a great potential to significantly improve the delivery of therapeutics brain and may also be equipped with properties investigate function. The brain, being highly complex organ shielded by selective barriers, requires its own specialized detection system. However, significant hurdle achieve these goals is still identification individual nanoparticles within sufficient cellular, subcellular, temporal resolution. This review aims provide comprehensive summary current knowledge on systems for tracking across blood-brain barrier brain. We discuss commonly employed in vivo ex nanoparticle quantification methods, as well various imaging modalities able detect Advantages weaknesses biological factors that must considered when interpreting results obtained through nanotechnologies are summarized. Finally, we critically evaluate prevailing limitations existing technologies explore solutions.

Language: Английский

Citations

3
Recent advances in biomedical applications of bacterial outer membrane vesicles DOI
Haiyan Chen,

Mengyuan Zhou,

Yuteng Zeng

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(37), P. 7384 - 7396

Published: Jan. 1, 2022

This review comprehensively covers the extraction, characterization, functionalization and biomedical applications of bacterial outer membrane vesicles (OMVs).

Language: Английский

Citations

14
Phytoestrogen-derived multifunctional ligands for targeted therapy of breast cancer DOI Creative Commons
Ying Zhang,

Hao Pan,

Changxiang Yu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100827 - 100827

Published: July 1, 2023

Nano-targeted delivery systems have been widely used for breast tumor drug delivery. Estrogen receptors are considered to be significant target due their overexpression in a variety of cells. However, targeted ligands impact on the safety and effectiveness active systems, limiting clinical transformation nanoparticles. Phytoestrogens shown good biosafety characteristics some affinity with estrogen receptor. In present study, molecular docking was select tanshinone IIA (Tan IIA) among phytoestrogens as ligand nanodelivery modifications. Modified Tan (Tan-NH2) showed profile demonstrated tumor-targeting, anti-tumor metastasis effects. Moreover, utilized Dox-loaded mesoporous silica nanoparticles via chemical modification generate nanocomposite Tan-Dox-MSN. Tan-Dox-MSN had uniform particle size, dispersibility high loading capacity. Validation experiments vivo vitro that it also better targeting ability, effect lower toxicity normal organs. These results supported idea receptor could improve therapeutic efficacy nano-targeted tumors.

Language: Английский

Citations

5
Nanomaterials for brain metastasis DOI
Zhenhao Zhao, Yun Chen, Tao Sun

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 833 - 847

Published: Dec. 16, 2023

Language: Английский

Citations

4