Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2024, Номер 654, С. 123976 - 123976
Опубликована: Март 6, 2024
As cancer being the most difficult disease to treat, different kinds of medications and therapeutic approaches have been prominently developed by scientists. For certain families drugs, such as immuno-therapeutics or antibody-drug conjugates, efficient delivery systems are required during administration protect drugs from chemical degradation biological inactivation. Delivery with ability carry therapeutics diagnostic agents both, hold promising potential tackle abnormalities behind cancer. In this context, review provides updated insights on how cyclodextrin-based polymeric nanosystems become an effective treatment approach against Cyclodextrins (CDs) natural oligosaccharides that famously exploited in pharmaceutical research due their exceptional quality entrapping water-insoluble molecules inside hydrophobic core providing enhanced solubility help hydrophilic exterior. Combining properties CDs nanoparticles (PNPs) brings out excellent versatile tunable profiles, thanks submicron-sized PNPs. By introducing significance CD a system, collective discussion binding release mechanisms CD-drug complexation, followed characterization studies has done review. Further, light recent studies, article majorly focuses conveying promoting nanoscale elevates multifunctional advantages can be successfully applied combination therapy theranostics. Moreover, CD-based including CALAA-01, CRLX101, CRLX301, demonstrated improved tumor targeting, reduced side effects, prolonged drug preclinical clinical trials.
Язык: Английский
Процитировано
15
Aging Cell, Год журнала: 2024, Номер 23(5)
Опубликована: Апрель 29, 2024
Abstract Senescence is a heterogenous and dynamic process in which various cell types undergo cell‐cycle arrest due to cellular stressors. While senescence has been implicated aging many human pathologies, therapeutic interventions remain inadequate the absence of comprehensive set biomarkers context‐dependent manner. Polyphenols have investigated as senotherapeutics both preclinical clinical settings. However, their use hindered by limited stability, toxicity, modest bioavailability, often concentration at target sites. To address these limitations, nanocarriers such polymer nanoparticles lipid vesicles can be utilized enhance efficacy senolytic polyphenols. Focusing on widely studied agents—specifically fisetin, quercetin, resveratrol—we provide concise summaries physical chemical properties, along with an overview findings. We also highlight common signaling pathways potential toxicities associated agents. Addressing challenges linked nanocarriers, we present examples senotherapeutic delivery types, without nanocarriers. Finally, continued research development agents are encouraged reduce undesirable effects different organs. This review underscores need for establishing reliable sets that could assist evaluating effectiveness current future candidates
Язык: Английский
Процитировано
14
Particle & Particle Systems Characterization, Год журнала: 2024, Номер unknown
Опубликована: Июнь 28, 2024
Abstract Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research exploring new approaches to improve efficacy reduce its effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays crucial role delivering often‐hydrophobic drugs, enhancing their bioavailability solubility. This area represents significant convergence nanotechnology both conventional pharmaceuticals botanical compounds. Global studies increasingly demonstrating the potential combination therapies inhibit cell growth laboratory preclinical models. These suggest synergistic or additive effects that lead improved treatment outcomes. article focuses on recent advancements nano‐drug delivery systems, specifically those designed for simultaneous phytochemicals. It explores selection phytochemicals based anticancer properties, outlines design considerations nanocarriers, discusses how physicochemical characteristics influence release kinetics. Additionally, review examines nanoformulations integrate synthetic natural components, highlighting herbal oils medicines treatment.
Язык: Английский
Процитировано
11
Computational Biology and Chemistry, Год журнала: 2025, Номер 117, С. 108390 - 108390
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
1
Опубликована: Фев. 2, 2025
Because of its long history use in traditional medicine, Flemingia macrophylla has attracted a lot attention from the fields phytochemistry and pharmacology. However, comprehensive research data on pharmacological roles have not been found literature. This review combines abundance information regarding application, phytochemical makeup, properties, demonstrating critical role Chinese medicine. Examining past uses many cultural contexts treating gastrointestinal issues to dermatological conditions highlights extraordinary adaptability. article reveals generations-long development as reliable medicine through an examination ethnobotanical records. Its composition is carefully examined this review, which complex array chemicals including flavonoids, alkaloids, terpenoids that are crucial comprehending plant's potential Determining consequences bioactive components plant requires thorough structural clarification. Pharmacological studies demonstrate range actions, antiinflammatory, antioxidant, cardiovascular benefits, consistent with conventional applications. antifungal function particular how useful it against microbial dangers general. Throughout, paper knowledge contemporary pharmacology convergent, emphasizing mutually beneficial interaction between legacy evidence-based treatment. Encapsulating historical significance current relevance integration into modern healthcare practices, compilation could be invaluable resource for researchers, herbalists, practitioners.
Язык: Английский
Процитировано
1
Translational research, Год журнала: 2024, Номер 268, С. 63 - 78
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
5
Archiv der Pharmazie, Год журнала: 2024, Номер 357(7)
Опубликована: Апрель 9, 2024
Piperlongumine, or piplartine (PL), is a bioactive alkaloid isolated from Piper longum L. and potent phytoconstituent in Indian Ayurveda traditional Chinese medicine with lot of therapeutic benefits. Apart all its biological activities, it demonstrates multimodal anticancer activity by targeting various cancer-associated pathways being less toxic to normal cells. According their structure-activity relationship (SAR), the trimethylphenyl ring (cinnamoyl core) 5,6-dihydropyridin-2-(1H)-one (piperdine are responsible for activity. However, has poor intrinsic properties (low aqueous solubility, bioavailability, etc.). As result, pharmaceutical researchers have been trying optimise modify structure PL improve drug-likeness profiles. The present review selected 26 eligible research articles on derivatives published between 2012 2023, followed preferred reporting items systematic reviews meta-analyses (PRISMA) format. We thoroughly summarised potency, mode action, SAR drug chemistry proposed PL-derivatives against different cancer Overall, analyses respect potency drug-ability revealed that substitution methoxy hydroxyl, attachment ligustrazine 4-hydroxycoumarin heterocyclic rings place phenyl rings, like indole at C7-C8 olefin position native can help activity, cell permeability, making them potential leads. Hopefully, large-scale collection critical drug-chemistry will be helpful academic developing potential, less-toxic cost-effective used cancers.
Язык: Английский
Процитировано
5
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(11), С. 5577 - 5597
Опубликована: Окт. 4, 2024
Malignant breast tumors constitute the most frequent cancer diagnosis among women. Notwithstanding progress in treatments, this condition persists as a major public health issue. Paclitaxel (PTX) is first-line classical chemotherapeutic drug used single active pharmaceutical ingredient (API) or combination therapy for (BC) treatment. Adverse effects, poor water solubility, and inevitable susceptibility to resistance seriously limit its therapeutic efficacy clinic. Piplartine (PPT), an alkaloid extracted from
Язык: Английский
Процитировано
1
Nanomedicine, Год журнала: 2024, Номер 19(14), С. 1227 - 1229
Опубликована: Апрель 30, 2024
“The development of phytonanomedicine-based approach seems to be a very promising candidate for modulating protumorigenic tumor microenvironment suppress cancer metastasis.”.
Язык: Английский
Процитировано
0
Advanced Therapeutics, Год журнала: 2024, Номер 7(10)
Опубликована: Авг. 20, 2024
Abstract Phytochemicals are a diverse class of compounds found in various plant‐based foods and beverages that have displayed the capacity to exert powerful anticancer effects through induction programed cell death (PCD) malignancies. PCD is sophisticated process maintains upholding tissue homeostasis eliminating injured or neoplastic cells. shown potential induce malignant cells mechanisms, including modulation signaling pathways, regulation reactive oxygen species (ROS), interaction with critical targets such as DNA. Moreover, recent studies suggested nanomaterials loaded phytochemicals may enhance tumors, which can also stimulate antitumor immunity. In this review, comprehensive overview current understanding their promising approach cancer therapy, provided. The impacts resveratrol, curcumin, apigenin, quercetin, some approved plant‐derived drugs, taxanes on types PCD, apoptosis, pyroptosis, anoikis, autophagic death, ferroptosis, necroptosis, discussed. underlying mechanisms tumors explained.
Язык: Английский
Процитировано
0