Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1419 - 1419
Опубликована: Ноя. 6, 2024
When
flowing
through
the
blood
stream,
drug
carriers
such
as
nanoparticles
encounter
hundreds
of
plasma
proteins,
forming
a
protein
layer
on
nanoparticle
surface,
known
"protein
corona".
Since
corona
influences
size,
shape,
and
surface
properties
nanoparticles,
it
can
modulate
their
circulating
lifetime,
cytotoxicity,
targeting
efficiency.
Therefore,
understanding
mechanism
formation
at
atomic
scale
is
crucial,
which
has
become
possible
due
to
advances
in
computer
power
simulation
methodologies.
This
review
covers
following
topics:
(1)
structure,
dynamics,
composition
nanoparticles;
(2)
effects
concentration
ionic
strength
formation;
(3)
particle
morphology,
(4)
interactions
among
lipids,
membranes,
with
corona.
For
each
topic,
mesoscale,
coarse-grained,
all-atom
molecular
dynamics
simulations
since
2020
are
discussed.
These
not
only
successfully
reproduce
experimental
observations
but
also
provide
physical
insights
into
formation.
In
particular,
these
findings
be
applied
manipulate
that
target
specific
cells,
aiding
rational
design
nanomedicines
for
delivery
applications.
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 186 - 186
Опубликована: Фев. 12, 2024
In
recent
years,
lipid
nanoparticles
(LNPs)
have
attracted
extensive
attention
in
tumor
immunotherapy.
Targeting
immune
cells
cancer
therapy
has
become
a
strategy
of
great
research
interest.
mRNA
vaccines
are
potential
choice
for
immunotherapy,
due
to
their
ability
directly
encode
antigen
proteins
and
stimulate
strong
response.
However,
the
mode
delivery
lack
stability
key
issues
limiting
its
application.
LNPs
an
excellent
carrier,
structural
biocompatibility
make
them
effective
means
delivering
specific
targets.
This
study
summarizes
progress
LNP
carrier-assisted
targeted
controlled
release
immunity.
The
role
improving
stability,
immunogenicity,
targeting
is
discussed.
review
aims
systematically
summarize
latest
immunity
provide
new
ideas
strategies
as
well
more
treatment
plans
patients.
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1521 - 1521
Опубликована: Ноя. 26, 2024
Lipid
nanoparticles
(LNPs)
have
shown
promise
as
a
delivery
system
for
nucleic
acid-based
therapeutics,
including
DNA,
siRNA,
and
mRNA
vaccines.
The
immune
plays
critical
role
in
the
response
to
these
nanocarriers,
with
innate
cells
initiating
an
early
adaptive
mediating
more
specific
reaction,
sometimes
leading
potential
adverse
effects.
Recent
studies
that
LNPs
is
mediated
by
Toll-like
receptors
(TLRs)
other
pattern
recognition
(PRRs),
which
recognize
lipid
components
of
nanoparticles.
This
can
trigger
activation
inflammatory
pathways
production
cytokines
chemokines,
effects
such
fever,
inflammation,
pain
at
injection
site.
On
hand,
appears
be
primarily
directed
against
protein
encoded
cargo,
little
evidence
ongoing
LNP
itself.
Understanding
relationship
between
development
safe
effective
systems.
In
fact,
targeting
essential
develop
vaccines,
well
therapies
cancer
or
infections.
There
lack
research
literature
has
systematically
studied
factors
influence
interaction
further
needed
better
elucidate
mechanisms
underlying
LNPs.
this
review,
we
discuss
LNPs’
composition,
physico-chemical
properties,
size,
shape,
surface
charge,
corona
formation
affect
reactivity
system,
thus
providing
guide
on
new
formulations
could
gain
favorable
efficacy/safety
profile.
Nanoscale Horizons,
Год журнала:
2024,
Номер
9(5), С. 799 - 816
Опубликована: Янв. 1, 2024
A
comparative
journey
into
biomolecular
corona
features
involving
proteomics,
lipidomics,
high
throughput
in
vitro
screening,
and
molecular
feature
analysis
to
investigate
the
vivo
/
bias
for
nanomaterials
testing
biology.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
The
adsorption
of
plasma
proteins
(human
serum
albumin
(SA)
and
apolipoproteins
A-I
E-III)
onto
various
lipid
bilayers
is
simulated.
With
three
different
binding
orientations
for
each
protein,
free
energy
calculations
from
umbrella
sampling
simulations
show
stronger
SA
to
the
bilayer
composed
lipids
with
smaller
headgroups
anionic
rather
than
cationic
or
zwitterionic
lipids,
in
agreement
experiments.
Anionic
residues
form
hydrogen
bonds
more
readily
amine
larger
trimethylammonium
headgroups,
where
nitrogen
sterically
hindered.
In
contrast,
predominantly
phosphate
groups
indicating
that
protein-bilayer
attributed
facilitated
by
electrostatic
attraction,
depending
on
electrostatics
size
headgroups.
For
grafted
polyethylene
glycol
(PEG),
strength
decreases
while
increases,
consistent
experiments,
due
bonding
hydrophobic
interactions
between
PEG.
These
findings
help
explain
experimental
observations
regarding
abundance
specific
adsorbed
liposomes
suggest
manipulating
composition
PEGylation
attract
liposome-based
drug
carriers.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Abstract
This
work
aimed
to
investigate
the
interaction
of
a
self‐assembled
myristic
acid‐conjugated
quetiapine
nanosuspension
(QMN)
with
human
serum
albumin
and
its
overturning
effect
on
QMN's
long‐acting
performance.
Albumin
corona
formation
modified
physicochemical
properties
pharmacokinetic
profile
QMN
by
pH‐responsiveness
nano‐aggregation
behavior.
The
adsorption
is
initially
triggered
electrostatic
forces
later
hydrophobic‐hydrophobic
interactions
conformational
change
structure.
While
highly
susceptible
ionic
strength,
pH,
concentration
in
solution,
albumin‐precoated
(A‐QMN)
stabilized
particle
size
reversed
surface
charge
from
≈+60
−16
mV,
annulling
pH‐responsive
nanoaggregation
behaviors
under
physiological
pH
conditions.
Consequently,
A‐QMNs
exhibited
much
faster
vitro
release
more
rapid
vivo
absorption,
resulting
huge
initial
burst
shorter
duration
within
one
week
plasma
concentration‐time
profiles
compared
extended
five‐week
following
intramuscular
injection
beagle
dogs.
These
findings
indicated
important
role
proteins
kinetics
pharmacokinetics
nanoparticles.
manipulation
protein
can
be
utilized
control
properties,
biological
states,
intended
nanosuspensions.
ACS Omega,
Год журнала:
2024,
Номер
9(32), С. 34624 - 34635
Опубликована: Июль 30, 2024
Currently
available
vaccines
against
COVID-19
showed
high
efficacy
the
original
strain
of
SARS-CoV-2
but
progressively
lower
new
variants.
In
response
to
emerging
strains,
we
propose
chimeric
DNA
encoding
spike
antigen,
including
a
combination
selected
key
mutations
from
different
variants
concern.
We
developed
two
vaccines,
pVAX-S1-TM-D614G
and
pVAX-S1-TM-INDUK
(INDUK),
S1
subunit
in
fusion
with
transmembrane
region
that
allows
protein
trimerization
as
predicted
by
