Targeted Molecular Imaging and Therapy Based on Nuclear and Optical Technologies DOI Open Access
Mikako Ogawa

Biological and Pharmaceutical Bulletin, Год журнала: 2024, Номер 47(6), С. 1066 - 1071

Опубликована: Май 31, 2024

Both nuclear and optical imaging are used for in vivo molecular imaging. Nuclear displays superior quantitativity, it permits deep tissues. Thus, this method is widely clinically. Conversely, because of the low permeability visible to near-IR light living animals, difficult visualize tissues via However, at these wavelengths has no ionizing effect, can be without any restrictions terms location. Furthermore, signals controlled accomplish target-specific medicine phototherapy have also evolved permit targeted-specific In targeted therapy, beta emitters conventionally used, but alpha received significant attention recently. Concerning phototherapy, photoimmunotherapy with was approved Japan 2020. article, therapy utilizing technologies discussed.

Язык: Английский

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules DOI Creative Commons
Aseem Setia, Bhaskar Vallamkonda,

Randheer Reddy Challa

и другие.

Nanotheranostics, Год журнала: 2024, Номер 8(3), С. 344 - 379

Опубликована: Янв. 1, 2024

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

Процитировано

12
Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics DOI Creative Commons

Samridhi Samridhi,

Aseem Setia, Abhishesh Kumar Mehata

и другие.

Nanotheranostics, Год журнала: 2024, Номер 8(2), С. 127 - 149

Опубликована: Янв. 1, 2024

Cardiovascular disease is one of the chief factors that cause ischemic stroke, myocardial infarction, and venous thromboembolism.The elements speed up thrombosis include nutritional consumption, physical activity, oxidative stress.Even though precise etiology pathophysiology remain difficult topics primarily rely on traditional medicine.The diagnosis management are being developed using discrete non-invasive non-surgical approaches.One emerging promising approach ultrasound photoacoustic imaging.The advancement nanomedicines offers concentrated therapy diagnosis, imparting efficacy fewer side effects which more significant than conventional medicine.This study addresses potential as theranostic agents for treatment thrombosis.In this article, we describe lead to its consequences, well summarize findings studies thrombus formation in preclinical clinical models also provide insights nanoparticles imaging therapy.

Язык: Английский

Процитировано

7
Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases DOI Creative Commons

Jyoti Bonlawar,

Aseem Setia,

Ranadheer Reddy Challa

и другие.

Nanotheranostics, Год журнала: 2024, Номер 8(3), С. 401 - 426

Опубликована: Янв. 1, 2024

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area therapy targeted nanomedicine.Nanotheranostics, which make use nanoparticles, are a significant advancement in MRI CT imaging.In addition to giving high-resolution anatomical features functional information simultaneously, these multifunctional agents improve contrast when used.In enabling early disease detection, precise localization, personalised monitoring, they also enable detection.Fusion enables vivo tracking drug-loaded nanoparticles.MRI, provides real-time monitoring nanoparticle distribution, accumulation, release at cellular tissue levels, can be used assess efficacy drug delivery systems.The localization nanoparticles within body is achievable through imaging.This technique enhances capabilities by providing information.CT allows for quantitative measurements concentration, essential evaluating pharmacokinetics biodistribution nanomedicine.In this article, we emphasize into molecular advanced diseases.

Язык: Английский

Процитировано

6
MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma DOI Creative Commons
Alessia Lo Dico, Viviana Costa, Cristina Martelli

и другие.

Theranostics, Год журнала: 2016, Номер 6(8), С. 1105 - 1118

Опубликована: Янв. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

Процитировано

46
Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity DOI Creative Commons
Aseem Setia,

Randheer Reddy Challa,

Bhaskar Vallamkonda

и другие.

Nanotheranostics, Год журнала: 2024, Номер 8(4), С. 473 - 496

Опубликована: Янв. 1, 2024

Cardiotoxicity, the often-overlooked second leading cause of death in cancer patients, has been associated with certain anticancer drugs. These drugs can induce cardiac damage through various pathways, and their adverse effects on heart are not fully understood. Cardiotoxicity is a major issue treatment, particularly chemotherapeutics, because it dysfunction such as hypotension, failure, even death. Doxorubicin, 5-fluorouracil, trastuzumab, all which very potent drugs, known to cardiotoxicity. When comes lowering cardiotoxicity alleviating harmful chemotherapy medications, nanomedicine potential transport therapeutic molecules. Nanotheranostics offers novel options for identifying treating resulting from wide range substances, including medications. Additionally, theranostics platforms micellar systems, carbon-based nanomedicine, solid lipid nanoparticles, polymeric liposomes chemotherapeutic medications while minimising The present level understanding molecular cellular processes that lead reaction both traditional targeted drug delivery systems summarised this article. This review delves into nanotheranostics, an emphasis reducing medication-induced toxicity. provide solutions early diagnosis tailored therapy injury by combining diagnostic capabilities nanomedicine.

Язык: Английский

Процитировано

5
Precision diagnosis of burn injuries using imaging and predictive modeling for clinical applications DOI Creative Commons
Pramod Rangaiah, B. P. Pradeep Kumar, Fredrik Huss

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 4, 2025

Burns represents a serious clinical problem because the diagnosis and assessment are very complex. This paper proposes methodology that combines use of advanced medical imaging with predictive modeling for improvement burn injury assessment. The proposed framework makes Adaptive Complex Independent Components Analysis (ACICA) Reference Region (TBSA) methods in conjunction deep learning techniques precise estimation depth Total Body Surface Area analysis. It also allows burns high accuracy, calculation TBSA, non-invasive analysis 96.7% accuracy using an RNN model. Extensive experimentation on DCE-LUV samples validates enhanced diagnostic precision detailed texture These technologies provide nuanced insights into severity, improving treatment planning. Our results demonstrate potential these to revolutionize care optimize patient outcomes.

Язык: Английский

Процитировано

0
Various Methods of Synthesis and Applications of Gold-Based Nanomaterials: A Detailed Review DOI Creative Commons
Misbah Gul, Muhammad Kashif, Sheraz Muhammad

и другие.

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

Процитировано

0
Advancing the potential of nanoparticles for cancer detection and precision therapeutics DOI

Muhammad Naeem Kiani,

Hamza Khaliq,

Muhammad Abubakar

и другие.

Medical Oncology, Год журнала: 2025, Номер 42(7)

Опубликована: Июнь 4, 2025

Язык: Английский

Процитировано

0
Recent Advancement of Indocyanine Green Based Nanotheranostics for Imaging and Therapy of Coronary Atherosclerosis DOI
Nidhi Verma, Aseem Setia, Abhishesh Kumar Mehata

и другие.

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(10), С. 4804 - 4826

Опубликована: Сен. 3, 2024

Atherosclerosis is a vascular intima condition in which any part of the circulatory system affected, including aorta and coronary arteries. Indocyanine green (ICG), theranostic compound approved by FDA, has shown promise treatment atherosclerosis after incorporation into nanoplatforms. By integration ICG with targeting agents such as peptides or antibodies, it feasible to increase its concentration damaged arteries, hence increasing detection. Nanotheranostics offers cutting-edge techniques for clinical diagnosis therapy atherosclerotic plaques. Combining optical properties those nanocarriers enables improved imaging plaques targeted therapeutic interventions. Several ICG-based nanotheranostics platforms have been developed polymeric nanoparticles, iron oxide biomimetic systems, liposomes, peptide-based etc. Theranostics use magnetic resonance (MRI), computed tomography (CT), near-infrared fluorescence (NIRF) imaging, photoacoustic/ultrasound positron emission (PET), single photon (SPECT) techniques. In addition there growing interest employing treat atherosclerosis. this review, we provide conceptual explanation Moreover, advancements modalities MRI, CT, PET, SPECT, ultrasound/photoacoustic discussed. Furthermore, highlight applications

Язык: Английский

Процитировано

2
Nanomedicine and clinical diagnostics part I: applications in conventional imaging (MRI, X-ray/CT, and ultrasound) DOI

Ahmad Butt,

Horacio Bach

Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Дек. 11, 2024

Integrating nanotechnologies in diagnostic imaging presents a promising step forward compared to traditional methods, which carry certain limitations. Conventional routes, such as X-ray/computed tomography and magnetic resonance imaging, derive significant advantages from nanoparticles (NPs), allow researchers clinicians overcome some of the limitations agents. In this literature review, we explore recent advancements nanomaterials being applied conventional techniques by exploring relevant reviews original research papers (e.g. experimental models theoretical model studies) literature. Collectively, there are numerous currently examined for use modalities, each technique has unique NPs with properties that can be manipulated answer an array clinical questions specific modality. There still challenges consider, including getting regulatory approval routine about long-term biocompatibility, collectively emphasize need continued facilitate integration nanotechnology into practice. Most importantly, is strong, collaborative efforts between researchers, biomedical engineers, clinicians, industry stakeholders, necessary bridge persistent gap translational ideas implementation settings.

Язык: Английский

Процитировано

2