Targeted Molecular Imaging and Therapy Based on Nuclear and Optical Technologies DOI Open Access
Mikako Ogawa

Biological and Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 47(6), P. 1066 - 1071

Published: May 31, 2024

Both nuclear and optical imaging are used for in vivo molecular imaging. Nuclear displays superior quantitativity, it permits deep tissues. Thus, this method is widely clinically. Conversely, because of the low permeability visible to near-IR light living animals, difficult visualize tissues via However, at these wavelengths has no ionizing effect, can be without any restrictions terms location. Furthermore, signals controlled accomplish target-specific medicine phototherapy have also evolved permit targeted-specific In targeted therapy, beta emitters conventionally used, but alpha received significant attention recently. Concerning phototherapy, photoimmunotherapy with was approved Japan 2020. article, therapy utilizing technologies discussed.

Language: Английский

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules DOI Creative Commons
Aseem Setia,

Bhaskar Vallamkonda,

Randheer Reddy Challa

et al.

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(3), P. 344 - 379

Published: Jan. 1, 2024

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Language: Английский

Citations

12
Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics DOI Creative Commons

Samridhi Samridhi,

Aseem Setia, Abhishesh Kumar Mehata

et al.

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 127 - 149

Published: Jan. 1, 2024

Cardiovascular disease is one of the chief factors that cause ischemic stroke, myocardial infarction, and venous thromboembolism.The elements speed up thrombosis include nutritional consumption, physical activity, oxidative stress.Even though precise etiology pathophysiology remain difficult topics primarily rely on traditional medicine.The diagnosis management are being developed using discrete non-invasive non-surgical approaches.One emerging promising approach ultrasound photoacoustic imaging.The advancement nanomedicines offers concentrated therapy diagnosis, imparting efficacy fewer side effects which more significant than conventional medicine.This study addresses potential as theranostic agents for treatment thrombosis.In this article, we describe lead to its consequences, well summarize findings studies thrombus formation in preclinical clinical models also provide insights nanoparticles imaging therapy.

Language: Английский

Citations

6
Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases DOI Creative Commons

Jyoti Bonlawar,

Aseem Setia,

Ranadheer Reddy Challa

et al.

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(3), P. 401 - 426

Published: Jan. 1, 2024

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area therapy targeted nanomedicine.Nanotheranostics, which make use nanoparticles, are a significant advancement in MRI CT imaging.In addition to giving high-resolution anatomical features functional information simultaneously, these multifunctional agents improve contrast when used.In enabling early disease detection, precise localization, personalised monitoring, they also enable detection.Fusion enables vivo tracking drug-loaded nanoparticles.MRI, provides real-time monitoring nanoparticle distribution, accumulation, release at cellular tissue levels, can be used assess efficacy drug delivery systems.The localization nanoparticles within body is achievable through imaging.This technique enhances capabilities by providing information.CT allows for quantitative measurements concentration, essential evaluating pharmacokinetics biodistribution nanomedicine.In this article, we emphasize into molecular advanced diseases.

Language: Английский

Citations

6
Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity DOI Creative Commons
Aseem Setia,

Randheer Reddy Challa,

Bhaskar Vallamkonda

et al.

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(4), P. 473 - 496

Published: Jan. 1, 2024

Cardiotoxicity, the often-overlooked second leading cause of death in cancer patients, has been associated with certain anticancer drugs. These drugs can induce cardiac damage through various pathways, and their adverse effects on heart are not fully understood. Cardiotoxicity is a major issue treatment, particularly chemotherapeutics, because it dysfunction such as hypotension, failure, even death. Doxorubicin, 5-fluorouracil, trastuzumab, all which very potent drugs, known to cardiotoxicity. When comes lowering cardiotoxicity alleviating harmful chemotherapy medications, nanomedicine potential transport therapeutic molecules. Nanotheranostics offers novel options for identifying treating resulting from wide range substances, including medications. Additionally, theranostics platforms micellar systems, carbon-based nanomedicine, solid lipid nanoparticles, polymeric liposomes chemotherapeutic medications while minimising The present level understanding molecular cellular processes that lead reaction both traditional targeted drug delivery systems summarised this article. This review delves into nanotheranostics, an emphasis reducing medication-induced toxicity. provide solutions early diagnosis tailored therapy injury by combining diagnostic capabilities nanomedicine.

Language: Английский

Citations

5
MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma DOI Creative Commons
Alessia Lo Dico, Viviana Costa, Cristina Martelli

et al.

Theranostics, Journal Year: 2016, Volume and Issue: 6(8), P. 1105 - 1118

Published: Jan. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Language: Английский

Citations

46
Precision diagnosis of burn injuries using imaging and predictive modeling for clinical applications DOI Creative Commons
Pramod Rangaiah, B. P. Pradeep Kumar, Fredrik Huss

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Burns represents a serious clinical problem because the diagnosis and assessment are very complex. This paper proposes methodology that combines use of advanced medical imaging with predictive modeling for improvement burn injury assessment. The proposed framework makes Adaptive Complex Independent Components Analysis (ACICA) Reference Region (TBSA) methods in conjunction deep learning techniques precise estimation depth Total Body Surface Area analysis. It also allows burns high accuracy, calculation TBSA, non-invasive analysis 96.7% accuracy using an RNN model. Extensive experimentation on DCE-LUV samples validates enhanced diagnostic precision detailed texture These technologies provide nuanced insights into severity, improving treatment planning. Our results demonstrate potential these to revolutionize care optimize patient outcomes.

Language: Английский

Citations

0
Various Methods of Synthesis and Applications of Gold-Based Nanomaterials: A Detailed Review DOI Creative Commons
Misbah Gul, Muhammad Kashif, Sheraz Muhammad

et al.

Crystal Growth & Design, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

0
Recent Advancement of Indocyanine Green Based Nanotheranostics for Imaging and Therapy of Coronary Atherosclerosis DOI
Nidhi Verma, Aseem Setia, Abhishesh Kumar Mehata

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(10), P. 4804 - 4826

Published: Sept. 3, 2024

Atherosclerosis is a vascular intima condition in which any part of the circulatory system affected, including aorta and coronary arteries. Indocyanine green (ICG), theranostic compound approved by FDA, has shown promise treatment atherosclerosis after incorporation into nanoplatforms. By integration ICG with targeting agents such as peptides or antibodies, it feasible to increase its concentration damaged arteries, hence increasing detection. Nanotheranostics offers cutting-edge techniques for clinical diagnosis therapy atherosclerotic plaques. Combining optical properties those nanocarriers enables improved imaging plaques targeted therapeutic interventions. Several ICG-based nanotheranostics platforms have been developed polymeric nanoparticles, iron oxide biomimetic systems, liposomes, peptide-based etc. Theranostics use magnetic resonance (MRI), computed tomography (CT), near-infrared fluorescence (NIRF) imaging, photoacoustic/ultrasound positron emission (PET), single photon (SPECT) techniques. In addition there growing interest employing treat atherosclerosis. this review, we provide conceptual explanation Moreover, advancements modalities MRI, CT, PET, SPECT, ultrasound/photoacoustic discussed. Furthermore, highlight applications

Language: Английский

Citations

2
Nanomaterial-based contrast agents for common disease imaging DOI Open Access
Jie Xing, Zihou Li,

Junlie Yao

et al.

Science China Materials, Journal Year: 2024, Volume and Issue: 67(4), P. 1288 - 1291

Published: March 25, 2024

Language: Английский

Citations

1
Chitosan nanoparticles in wound healing and dressing application DOI
Abhishesh Kumar Mehata, Chandrashekhar Singh, Ankit Kumar Malik

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 527 - 580

Published: Nov. 29, 2024

Language: Английский

Citations

1