Preparation and In Vitro/In Vivo Characterization of Mixed-Micelles-Loaded Dissolving Microneedles for Sustained Release of Indomethacin DOI Creative Commons

Baojie Wang,

Langkun Liao,

Huihui Liang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1505 - 1505

Published: Nov. 22, 2024

Background/Objectives: Indomethacin (IDM) is commonly used to treat chronic inflammatory diseases such as rheumatoid arthritis and osteoarthritis. However, long-term oral IDM treatment can harm the gastrointestinal tract. This study presents a design for encapsulating within mixed micelles (MMs)-loaded dissolving microneedles (DMNs) improve sustain transdermal drug delivery. Methods: Indomethacin-loaded (IDM-MMs) were prepared from Soluplus® Poloxamer F127 by means of thin-film hydration method. The MMs-loaded DMNs fabricated using two-step molding method evaluated storage stability, insertion ability, in vitro release, penetration, vivo PK/PD studies. Results: obtained MMs stable at 4 °C 30 60 days. penetration was remarkably improved compared commercial patch. A pharmacokinetic demonstrated that had relative bioavailability 4.1 comparison with Furthermore, showed significantly shorter lag time than patch, well more plasma concentration without MMs. therapeutic efficacy examined Complete Freund's Adjuvant-induced mice. DMN effectively reduced severity, resulting decreased paw swelling, index, spleen hyperplasia, serum IL-1β TNF-α levels. Conclusions: Our findings novel an effective strategy sustained providing alternate route anti-inflammatory

Language: Английский

Unveiling the potential of inorganic nanoarchitecture-mediated photothermal therapy: An illustration on melanoma DOI

Aachal Hedaoo,

Pooja Khairnar,

Ganesh Vambhurkar

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 216, P. 113282 - 113282

Published: July 2, 2024

Language: Английский

Citations

5
Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing DOI Creative Commons

Mohammad Amin Khalilzad,

Javad Mohammadi,

Soumayeh Amirsaadat

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0
Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing DOI Creative Commons
Zhen Zhang, Yulin Zhang,

Liang Peng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101739 - 101739

Published: April 1, 2025

Diabetic wounds (DW) represent a significant clinical challenge due to chronic inflammation, excessive oxidative stress, and impaired angiogenesis, all of which hinder effective tissue regeneration. Existing drug delivery systems often fail achieve sustained targeted therapeutic efficacy. In this study, we developed novel dissolvable dual-layer methacrylated gelatin (GelMA) microneedle (MN) co-loading selenium-doped carbon quantum dots (Se-CQDs) Astilbin (AST) for enhanced DW treatment. The outer layer, enriched with Se-CQDs, rapidly scavenges reactive oxygen species (ROS), effectively alleviating stress at the wound site. Sequentially, inner layer releases AST, exerting potent anti-inflammatory pro-angiogenic effects. Preliminary findings suggest these effects may involve modulation cytoskeletal dynamics peroxisome function, contributing endothelial cell migration angiogenesis. This controlled, sequential release MN establishes low-oxidative, microenvironment, thereby promoting angiogenesis accelerating repair. pioneering integration AST-loaded hydrogels offers synergistic strategy, setting new standard advanced diabetic care substantial promise.

Language: Английский

Citations

0
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations DOI Creative Commons
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Intraoral delivery of active pharmaceutical ingredients (API) is an attractive approach to improve their local therapeutic efficacy or enable systemic delivery. It offers several advantages, such as high drug concentration at the intraoral target site and rapid access circulation due vascularization oral cavity, bypassing first‐pass metabolism. However, limitations need be addressed, relatively short residence time formulations applied in cavity salivation, swallowing reflex, tongue movement, well poor membrane permeability of, particular, hydrophilic drugs. Within this review, a comprehensive summary latest strategies formulation approaches field provided, focusing on those pursued by academia industry overcome challenges. An overview provided excipients that are generally recognized safe (GRAS) utilized enhance systems, mucoadhesive materials, enzyme inhibitors, permeation enhancers. Innovative dosage forms outlined, covering solid, semi‐solid, liquid systems aerosols. Future trends, including self‐emulsifying microneedles, situ bioprinting, explored, presenting new opportunities for

Language: Английский

Citations

0
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives DOI

Madhuchandra Kenchegowda,

Mohit Angolkar, Umme Hani

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Preparation and In Vitro/In Vivo Characterization of Mixed-Micelles-Loaded Dissolving Microneedles for Sustained Release of Indomethacin DOI Creative Commons

Baojie Wang,

Langkun Liao,

Huihui Liang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1505 - 1505

Published: Nov. 22, 2024

Background/Objectives: Indomethacin (IDM) is commonly used to treat chronic inflammatory diseases such as rheumatoid arthritis and osteoarthritis. However, long-term oral IDM treatment can harm the gastrointestinal tract. This study presents a design for encapsulating within mixed micelles (MMs)-loaded dissolving microneedles (DMNs) improve sustain transdermal drug delivery. Methods: Indomethacin-loaded (IDM-MMs) were prepared from Soluplus® Poloxamer F127 by means of thin-film hydration method. The MMs-loaded DMNs fabricated using two-step molding method evaluated storage stability, insertion ability, in vitro release, penetration, vivo PK/PD studies. Results: obtained MMs stable at 4 °C 30 60 days. penetration was remarkably improved compared commercial patch. A pharmacokinetic demonstrated that had relative bioavailability 4.1 comparison with Furthermore, showed significantly shorter lag time than patch, well more plasma concentration without MMs. therapeutic efficacy examined Complete Freund's Adjuvant-induced mice. DMN effectively reduced severity, resulting decreased paw swelling, index, spleen hyperplasia, serum IL-1β TNF-α levels. Conclusions: Our findings novel an effective strategy sustained providing alternate route anti-inflammatory

Language: Английский

Citations

3