Perylenediimides with Enhanced Autophagy Inhibition for a Dual-Light Activatable Photothermal Gas Therapy

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(29), С. 34427 - 34435

Опубликована: Июль 14, 2023

Photothermal therapy (PTT) has emerged as a promising strategy for the treatment of tumors. However, intrinsic self-repair mechanism cells and nonspecific photothermal effect agents can result in poor outcomes normal tissue injury. To address this issue, we developed dual light activatable perylenediimide derivative (P-NO) nitric oxide-enhanced PTT. P-NO self-assemble into nanoparticles aqueous solutions. The are capable releasing both NO molecule (P-NH) upon green irradiation. simultaneous release P-NH activates inhibits cell protection autophagy, thereby improving therapeutic efficacy PTT under near-infrared (NIR) light. Moreover, switch on NIR fluorescence allows real-time monitoring P-NH. Remarkably, mouse subcutaneous tumor model, significant ablation be achieved following activated gas therapy. This work offers straightforward approach to constructing perylenediimide-based enhancing effectiveness

Язык: Английский

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Rhodium–Rhenium Alloy Nanozymes for Non-inflammatory Photothermal Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(17), С. 21653 - 21664

Опубликована: Апрель 22, 2024

Analogous to thermal ablation techniques in clinical settings, cell necrosis induced during tumor photothermal therapy (PTT) can provoke an inflammatory response that is detrimental the treatment of tumors. In this study, we employed a straightforward one-step liquid-phase reduction process synthesize uniform RhRe nanozymes with average hydrodynamic size 41.7 nm for non-inflammatory therapy. The obtained showed efficient near-infrared (NIR) light absorption effective PTT, coupled remarkable capability scavenge reactive oxygen species (ROS) anti-inflammatory treatment. After laser irradiation, 4T1 tumors were effectively ablated without obvious recurrence within 14 days, along no increase pro-inflammatory cytokine levels. Notably, these demonstrated high biocompatibility normal cells and tissues, both

Язык: Английский

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Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 16, 2024

Abstract Reactive oxygen species (ROS)-associated anticancer approaches usually suffer from two limitations, i.e., insufficient ROS level and short half-life. Nevertheless, no report has synchronously addressed both concerns yet. Herein, a multichannel actions-enabled nanotherapeutic platform using hollow manganese dioxide (H-MnO 2 ) carriers to load chlorin e6 (Ce6) sonosensitizer CO donor (e.g., Mn (CO) 10 been constructed maximumly elevate trigger cascade catalysis produce CO. Therein, intratumoral H O ultrasound as endogenous exogeneous triggers stimulate H-MnO Ce6 •OH 1 , respectively. The further reaction between proceeds release CO, converting short-lived into long-lived Contributed by them, such maximumly-elevated accumulation successfully suppresses the progression, recurrence metastasis of lung cancer with prolonged survival rate. More significantly, proteomic genomic investigations uncover that CO-induced activation AKT signaling pathway, NRF-2 phosphorylation HMOX-1 overexpression induce mitochondrial dysfunction boost anti-tumor consequences. Thus, this strategy can behave general means enrich against refractory cancers. Graphic

Язык: Английский

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NIR-Absorbing Tetraphenylethene-Containing bisBODIPY Nanoplatforms Demonstrate Effective Lysosome-Targeting and Combinational Phototherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(32), С. 41916 - 41926

Опубликована: Июль 31, 2024

Photosensitizer-based phototherapies, including photodynamic therapy (PDT) and photothermal (PTT), offer safe treatment modalities for tumor ablation with spatiotemporal precision. After photons are absorbed, PDT creates localized chemical damage by generating reactive oxygen species (ROS), while PTT induces thermal damage. However, still faces hypoxic challenges, encounters issues related to heat resistance potential overheating. The combination of shows great as an effective anticancer strategy. By targeting lysosomes carefully designed phototherapeutic reagents combined phototherapy, rapid dysfunction cell death in cancer cells can be induced, showing promise treatment. Herein, two α–α-linked bisBODIPYs tetraphenylethene (TPE) moieties synthesized. These TPE-substituted expand the absorption into NIR range (λmaxabs/λmaxem ∼ 740/810 nm) confer aggregation-induced emission (AIE) activity (λmaxem 912 nm). Moreover, these self-assemble surfactant F-127 nanoparticles (NPs), which efficiently generate ROS (1O2 •OH) both solution cellular environments demonstrate superior conversion efficiencies (η 68.3%) along exceptional stability. More importantly, NPs showed lysosomal remarkable murine models, indicating their precision therapy.

Язык: Английский

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Diagnostic and therapeutic nanoenzymes for enhanced chemotherapy and photodynamic therapy

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(18), С. 3925 - 3934

Опубликована: Янв. 1, 2021

We creatively designed a nanodrug delivery system of MnO₂-PTX/Ce6@lips based on the catalytic activity MnO₂ NPs. synthesized highly dispersible catalase-like nanozyme and successfully encapsulated it into liposomes.

Язык: Английский

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