Advanced Materials Interfaces,
Год журнала:
2021,
Номер
8(20)
Опубликована: Сен. 17, 2021
Abstract
Field‐effect
transistors
(FETs)
with
nanoscale
channels
have
emerged
as
excellent
platforms
for
constructing
high‐sensitivity
biosensors.
However,
in
typical
FET‐based
biosensors,
the
electronic
perturbation
at
channel/electrolyte
interfaces
results
poor
stability
and
severe
signal
drifts,
making
long‐term
continuous
measurements
quite
challenging.
To
address
this
issue,
here
dielectric/semiconductor
interface
is
tailored
by
depositing
an
ultrathin
layer
of
Al
2
O
3
(≈7
nm
thickness)
on
In
FETs
via
solution‐based
processes.
The
show
that
dielectric
layers
effectively
passivate
channel
endow
device
low
operation
voltage
(0.05
V),
high
sensitivity
(61.9
mV
pH
−1
),
current
drift
(0.35
h
)
upon
monitoring.
This
work
paves
way
to
real‐time
biosensing
sensitivity,
stability,
power
consumption.
The Analyst,
Год журнала:
2021,
Номер
146(22), С. 6684 - 6725
Опубликована: Янв. 1, 2021
Detection
and
recognition
of
chemical
biological
species
via
sensor
electronics
are
important
not
only
for
various
sensing
applications
but
also
fundamental
scientific
understanding.
In
the
past
two
decades,
devices
using
one-dimensional
(1D)
nanowires
have
emerged
as
promising
powerful
platforms
electrical
detection
biologically
relevant
molecules
due
to
their
superior
performance,
long-term
stability,
ultra-low
power
consumption.
This
paper
presents
a
comprehensive
overview
recent
progress
achievements
in
1D
nanowire
synthesis,
working
principles
nanowire-based
sensors,
analytes
recognition.
addition,
some
critical
issues
that
hinder
practical
electronics,
including
device
reproducibility
selectivity,
consumption,
will
be
highlighted.
Finally,
challenges,
perspectives,
opportunities
developing
advanced
innovative
featured.
Journal of Physics D Applied Physics,
Год журнала:
2021,
Номер
55(15), С. 153001 - 153001
Опубликована: Дек. 7, 2021
Abstract
Cancer
is
an
incurable
disease,
and
the
treatment
process
extremely
painful.
Early
detection
may
ease
prevent
cancer
from
spreading
beyond
primary
disease
area.
However,
conventional
screening
tests
have
long
times
lack
required
sensitivity
for
early
detection.
Consequently,
traditional
biosensors,
including
amplification
refractory
mutation
system,
digital
polymerase
chain
reaction,
next
generation
sequencing,
western
blot,
electrochemical,
mechanical
been
studied
in
recent
years.
Specifically,
field
effect
transistor
(FET)
are
attractive
pocketable
devices
with
short
time
capabilities.
Because
FET
biosensors
outstanding
electrical
properties,
their
efficacy
of
cancer.
Traditional
methods
biomarkers
include
use
biomarkers,
especially
gene,
antigen,
protein
characteristics.
This
review
presents
latest
strategies
applications
biosensing
compares
advantages
disadvantages
regarding
sensing
principle,
configuration,
performance.
Especially,
which
antibodies,
nucleic
acids,
proteins
highlighted.
Mechanical
properties
on
performance
discussed.
provides
a
guiding
role
design
development
FET-based
biosensors.
National Science Review,
Год журнала:
2024,
Номер
11(5)
Опубликована: Март 27, 2024
ABSTRACT
Single-nucleotide
variants
(SNVs)
are
the
most
common
type
variation
of
sequence
alterations
at
a
specific
location
in
genome,
thus
involving
significant
clinical
and
biological
information.
The
assay
SNVs
has
engaged
great
awareness,
because
many
genome-wide
association
studies
demonstrated
that
highly
associated
with
serious
human
diseases.
Moreover,
investigation
SNV
expression
levels
single
cells
capable
visualizing
genetic
information
revealing
complexity
heterogeneity
single-nucleotide
mutation-related
Thus,
developing
approaches
vitro,
particularly
cells,
is
becoming
increasingly
demand.
In
this
review,
we
summarized
recent
progress
enzyme-free
enzyme-mediated
strategies
enabling
transition
from
sensing
interface
to
test
tube
which
will
potentially
delve
deeper
into
knowledge
functions
disease
associations,
as
well
discovering
new
pathways
diagnose
treat
diseases
based
on
individual
profiles.
leap
achievements
motivate
observation
measurement
variations
even
within
living
organisms,
open
up
entirely
avenues
diagnosis
treatment
Advanced Materials Interfaces,
Год журнала:
2021,
Номер
8(20)
Опубликована: Сен. 17, 2021
Abstract
Field‐effect
transistors
(FETs)
with
nanoscale
channels
have
emerged
as
excellent
platforms
for
constructing
high‐sensitivity
biosensors.
However,
in
typical
FET‐based
biosensors,
the
electronic
perturbation
at
channel/electrolyte
interfaces
results
poor
stability
and
severe
signal
drifts,
making
long‐term
continuous
measurements
quite
challenging.
To
address
this
issue,
here
dielectric/semiconductor
interface
is
tailored
by
depositing
an
ultrathin
layer
of
Al
2
O
3
(≈7
nm
thickness)
on
In
FETs
via
solution‐based
processes.
The
show
that
dielectric
layers
effectively
passivate
channel
endow
device
low
operation
voltage
(0.05
V),
high
sensitivity
(61.9
mV
pH
−1
),
current
drift
(0.35
h
)
upon
monitoring.
This
work
paves
way
to
real‐time
biosensing
sensitivity,
stability,
power
consumption.
