A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(6), С. 2475 - 2504

Опубликована: Март 20, 2024

Resistance to cancer immunotherapy is mainly attributed poor tumor immunogenicity as well the immunosuppressive microenvironment (TME) leading failure of immune response. Numerous therapeutic strategies including chemotherapy, radiotherapy, photodynamic, photothermal, magnetic, chemodynamic, sonodynamic and oncolytic therapy, have been developed induce immunogenic cell death (ICD) cells thereby elicit boost antitumor However, many challenges hamper clinical application ICD inducers resulting in modest Here, we outline current state using nanomedicines for boosting cells. Moreover, synergistic approaches used combination with inducing remodeling TME

Язык: Английский

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Язык: Английский

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Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(36)

Опубликована: Март 4, 2024

Abstract Immunogenic cell death (ICD) is a promising strategy for anticancer immunity by inducing antigen‐presenting maturation. However, the traditional ICD inducers, such as chemotherapeutic agents, have largely hampered their application severe side effects and low tumor selectivity. The changes intra/extracellular ion concentrations affect growth metastasis of cells. Interference with homeostasis can induce elicit immune responses. Here, biomimetic Ga‐based metal–organic framework (MOF) coated red blood cell–platelet fusion membrane (RPM), that is, 5‐fluorouracil@GaMOF@RPM (5‐FUGR) nano‐immunoactivator, reported highly efficient inducer enhanced microwave (MW)‐immunotherapy. Following intravenous administration, 5‐FUGR accumulates to site via RPM modification‐mediated long circulation active targeting. structure undergoes degradation releases Ga 3+ . MW combined high disrupts intracellular homeostasis, which leads oxidative stress Ca 2+ retention promote apoptosis More importantly, not only completely eradicates 4T1 primary tumors, but also induces ICD, initiation, memory inhibit metastatic recurrence tumor. Thus, 5‐FUGR, strong inducer, provides new insights into achieving in combination other therapies.

Язык: Английский

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Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215969 - 215969

Опубликована: Июнь 10, 2024

Язык: Английский

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Hypoxia-Specific Metal–Organic Frameworks Augment Cancer Immunotherapy of High-Intensity Focused Ultrasound

ACS Nano, Год журнала: 2024, Номер 18(28), С. 18412 - 18424

Опубликована: Июль 1, 2024

As a noninvasive treatment modality, high-intensity focused ultrasound (HIFU)-induced antitumor immune responses play vital role in surgery prognosis. However, limited response intensity largely hinders postoperative immunotherapy. Herein, hypoxia-specific metal-organic framework (MOF) nanosystem, coordinated by Fe3+, hypoxic-activated prodrug AQ4N, and IDO-1 signaling pathway inhibitor NLG919, is developed for the potentiating immunotherapy of HIFU surgery. The loaded AQ4N enhances photoacoustic imaging effects to achieve accurate intraoperative navigation. Within HIFU-established severe hypoxic environment, activated sequentially, following which it cooperates with Fe3+ effectively provoke immunogenic cell death. In addition, potent NLG919 suppresses activity degrades immunosuppressive tumor microenvironment aggravated hypoxia. vivo studies demonstrate that MOF-mediated greatly inhibits growth primary/distant tumors eliminates lung metastasis. This work establishes robust delivery platform improve overall prognosis high specificity potency.

Язык: Английский

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Metalloptosis: Metal Ions-Induced Programmed Cell Death Based on Nanomaterials for Cancer Therapy

MedMat., Год журнала: 2024, Номер 1(1), С. 6 - 26

Опубликована: Июнь 19, 2024

Programmed cell death (PCD) is defined as regulated controlled by an intracellular program. While apoptosis was once thought to be the only kind of PCD, current understanding has expanded include other forms such pyroptosis, autophagy, and necroptosis. These processes, especially necroptosis, serve natural defenses that restrict cancer cells from surviving disseminating. However, have evolved various strategies evade including genetic mutations epigenetic modifications in key modulators PCD pathways. With continuous development nanotechnology, emerging nanomaterials (NMs) are considered break through this bottleneck due their intrinsic physicochemical properties. Especially, new kinds induced NMs, ferroptosis, cuproptosis, calcium overload, show gratifying potential therapy, which closely linked role metal ions. Additionally, ions-induced sodium zinc also emerged endless stream. Hence, we propose term “metalloptosis” describe ions summarize its application therapy NMs. This review will delve into critical design principles for engineering NMs involved metalloptosis provide a comprehensive summary ions-mediated therapies, focusing on nanoplatforms mechanisms action. We hope perspective based nanotechnology.

Язык: Английский

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Nanomedicine-induced programmed cell death in cancer therapy: mechanisms and perspectives

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Авг. 29, 2024

The balance of programmed cell death (PCD) mechanisms, including apoptosis, autophagy, necroptosis and others, is pivotal in cancer progression treatment. Dysregulation these pathways results uncontrolled growth resistance to conventional therapies. Nanomedicine offers a promising solution oncology through targeted drug delivery enabling precise targeting cells while preserving healthy tissues. This approach reduces the side effects traditional chemotherapy enhances treatment efficacy by engaging PCD pathways. We details each pathway, their innovative nanomedicine strategies activate pathways, thereby enhancing therapeutic specificity minimizing harm precision nanotechnology promises significant improvements outcomes. synergy between activation could lead more effective less toxic therapies, heralding new era

Язык: Английский

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Developing Upconversion (Yb³⁺–Er³⁺) and Downshifting (Yb³⁺–Ho³⁺–Er³⁺) PEG-Ylated Na₃ZrF₇ Degradable Nanoparticles as Ratiometric Luminescent Nanothermometers for Theranostic Applications

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

In this work, we report the synthesis of Na3ZrF7 nanoparticles as an appealing host matrix for lanthanide ions both upconversion (bidoped, sensitizer-activator Yb3+-Er3+ in vis and NIR-I regions) downshifting (tridoped, sensitizer-activator-activator Yb3+-Ho3+-Er3+ NIR-II region) ratiometric luminescence nanothermometry physiological temperature range (293.15-323.15 K). We explored three different routes to reveal most favorable synthetic approach bioapplication purposes well investigated characterized temperature-dependent photoluminescence (PL) properties obtained nanoparticles. Furthermore, a biocompatible DSPE-PEG2000-based layer was incorporated render water-dispersible subsequently evaluate their degradation-induced vitro toxicity toward HeLa Normal Human Dermal Fibroblast (NHDF) cells. Additional tests were conducted preliminarily cellular uptake future biological applications. show that conditions solvent environment influence morphology, crystalline phase, PL emission profiles. To best our knowledge, is first effort at extensive systematic nanosized core-only core-shell(s) materials luminescent thermometers reported temperature-sensing performance via (NIR-I-to-vis) (NIR-I-to-NIR-II) mechanisms material, cyclohexane aqueous environment.

Язык: Английский

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An Aged Tree with a New Bloom: A Simple Spatiotemporal Programming Strategy Enables Carbon Dot Photosensitizers to Regulate Cell Pyroptosis for Enhanced Tumor Photodynamic-Immunotherapy

Nano Letters, Год журнала: 2024, Номер 24(46), С. 14709 - 14719

Опубликована: Ноя. 6, 2024

Pyroptosis induced by photodynamic therapy (PDT) is a promising field in both PDT and immunotherapy for tumors. However, effectively inducing tumor cell pyroptosis while triggering strong immune response using current photosensitizers remains challenging. Herein, the developed positively charged carbon dots (PCDs) nanoPSs were utilized to modulate first time through simple spatiotemporal programming strategy. Briefly, PCDs enabled precisely time-dependent targeting of membrane or lysosome. Upon light irradiation,

Язык: Английский

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