A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 20, 2025

Language: Английский

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Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2475 - 2504

Published: March 20, 2024

Resistance to cancer immunotherapy is mainly attributed poor tumor immunogenicity as well the immunosuppressive microenvironment (TME) leading failure of immune response. Numerous therapeutic strategies including chemotherapy, radiotherapy, photodynamic, photothermal, magnetic, chemodynamic, sonodynamic and oncolytic therapy, have been developed induce immunogenic cell death (ICD) cells thereby elicit boost antitumor However, many challenges hamper clinical application ICD inducers resulting in modest Here, we outline current state using nanomedicines for boosting cells. Moreover, synergistic approaches used combination with inducing remodeling TME

Language: Английский

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Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 4, 2024

Abstract Immunogenic cell death (ICD) is a promising strategy for anticancer immunity by inducing antigen‐presenting maturation. However, the traditional ICD inducers, such as chemotherapeutic agents, have largely hampered their application severe side effects and low tumor selectivity. The changes intra/extracellular ion concentrations affect growth metastasis of cells. Interference with homeostasis can induce elicit immune responses. Here, biomimetic Ga‐based metal–organic framework (MOF) coated red blood cell–platelet fusion membrane (RPM), that is, 5‐fluorouracil@GaMOF@RPM (5‐FUGR) nano‐immunoactivator, reported highly efficient inducer enhanced microwave (MW)‐immunotherapy. Following intravenous administration, 5‐FUGR accumulates to site via RPM modification‐mediated long circulation active targeting. structure undergoes degradation releases Ga 3+ . MW combined high disrupts intracellular homeostasis, which leads oxidative stress Ca 2+ retention promote apoptosis More importantly, not only completely eradicates 4T1 primary tumors, but also induces ICD, initiation, memory inhibit metastatic recurrence tumor. Thus, 5‐FUGR, strong inducer, provides new insights into achieving in combination other therapies.

Language: Английский

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

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Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969

Published: June 10, 2024

Language: Английский

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Hypoxia-Specific Metal–Organic Frameworks Augment Cancer Immunotherapy of High-Intensity Focused Ultrasound

ACS Nano, Journal Year: 2024, Volume and Issue: 18(28), P. 18412 - 18424

Published: July 1, 2024

As a noninvasive treatment modality, high-intensity focused ultrasound (HIFU)-induced antitumor immune responses play vital role in surgery prognosis. However, limited response intensity largely hinders postoperative immunotherapy. Herein, hypoxia-specific metal-organic framework (MOF) nanosystem, coordinated by Fe3+, hypoxic-activated prodrug AQ4N, and IDO-1 signaling pathway inhibitor NLG919, is developed for the potentiating immunotherapy of HIFU surgery. The loaded AQ4N enhances photoacoustic imaging effects to achieve accurate intraoperative navigation. Within HIFU-established severe hypoxic environment, activated sequentially, following which it cooperates with Fe3+ effectively provoke immunogenic cell death. In addition, potent NLG919 suppresses activity degrades immunosuppressive tumor microenvironment aggravated hypoxia. vivo studies demonstrate that MOF-mediated greatly inhibits growth primary/distant tumors eliminates lung metastasis. This work establishes robust delivery platform improve overall prognosis high specificity potency.

Language: Английский

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GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 25, 2025

Abstract Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays central role as the key effector molecule. GSDMD-mediated pyroptosis characterized by complex biological features and considerable heterogeneity its expression, mechanisms, functional outcomes across various tissues, types, pathological microenvironments. This particularly pronounced inflammation-related diseases tumors. In context diseases, GSDMD expression typically upregulated, activation macrophages, neutrophils, T cells, epithelial mitochondria triggers both pyroptotic non-pyroptotic pathways, leading to release pro-inflammatory cytokines exacerbation tissue damage. However, under certain conditions, may also serve protective immune function. The tumors more manner, where it can either promote evasion or, some instances, induce tumor death. As our understanding GSDMD's continues progress, there have been advancements development inhibitors targeting pyroptosis; however, these therapeutic interventions remain preclinical phase. review systematically examines cellular molecular complexities pyroptosis, with particular emphasis on roles cancer. Furthermore, underscores substantial potential target for precision medicine, highlighting promising clinical applications.

Language: Английский

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Citrate oscillations during cell cycle are a targetable vulnerability in cancer cells

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189313 - 189313

Published: April 1, 2025

Cell cycle progression is timely interconnected with oscillations in cellular metabolism. Here, we first describe how these metabolic allow cycling cells to meet the bioenergetic needs specifically for each phase of cell cycle. In parallel, highlight cytosolic level citrate dynamically regulated during different phases, being low G1 phase, increasing S peaking G2/M, and decreasing mitosis. Of note, cancer cells, a dysregulation such oscillation can support by promoting deregulated Warburg effect (aerobic glycolysis), activating oncogenic signaling pathways (such as PI3K/AKT), acetyl-CoA production via alternative routes, overconsumption acetate. Then, review administration sodium (at high doses) arrests G0/G1 or inhibits glycolysis PI3K/AKT, induces apoptosis, significantly reduces tumor growth various vivo models. Last, reason on possibility implement reinforce effectiveness inhibitors better cure cancer.

Language: Английский

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Metalloptosis: Metal Ions-Induced Programmed Cell Death Based on Nanomaterials for Cancer Therapy

MedMat., Journal Year: 2024, Volume and Issue: 1(1), P. 6 - 26

Published: June 19, 2024

Programmed cell death (PCD) is defined as regulated controlled by an intracellular program. While apoptosis was once thought to be the only kind of PCD, current understanding has expanded include other forms such pyroptosis, autophagy, and necroptosis. These processes, especially necroptosis, serve natural defenses that restrict cancer cells from surviving disseminating. However, have evolved various strategies evade including genetic mutations epigenetic modifications in key modulators PCD pathways. With continuous development nanotechnology, emerging nanomaterials (NMs) are considered break through this bottleneck due their intrinsic physicochemical properties. Especially, new kinds induced NMs, ferroptosis, cuproptosis, calcium overload, show gratifying potential therapy, which closely linked role metal ions. Additionally, ions-induced sodium zinc also emerged endless stream. Hence, we propose term “metalloptosis” describe ions summarize its application therapy NMs. This review will delve into critical design principles for engineering NMs involved metalloptosis provide a comprehensive summary ions-mediated therapies, focusing on nanoplatforms mechanisms action. We hope perspective based nanotechnology.

Language: Английский

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Nanomedicine-induced programmed cell death in cancer therapy: mechanisms and perspectives

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 29, 2024

The balance of programmed cell death (PCD) mechanisms, including apoptosis, autophagy, necroptosis and others, is pivotal in cancer progression treatment. Dysregulation these pathways results uncontrolled growth resistance to conventional therapies. Nanomedicine offers a promising solution oncology through targeted drug delivery enabling precise targeting cells while preserving healthy tissues. This approach reduces the side effects traditional chemotherapy enhances treatment efficacy by engaging PCD pathways. We details each pathway, their innovative nanomedicine strategies activate pathways, thereby enhancing therapeutic specificity minimizing harm precision nanotechnology promises significant improvements outcomes. synergy between activation could lead more effective less toxic therapies, heralding new era

Language: Английский

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