Advanced Functional Materials,
Год журнала:
2020,
Номер
31(6)
Опубликована: Окт. 27, 2020
Abstract
2D
monoelemental
nanomaterials
(Xenes)
have
shown
tremendous
potential
for
versatile
biomedical
applications.
Bismuth,
as
a
heavy
element
in
pnictogens,
has
acquired
massive
research
interest
due
to
its
unique
optical
performance,
high
biocompatibility,
stability,
and
relatively
low
cost.
However,
the
utilization
of
bismuthene
nanomedicine
not
been
achieved
because
difficulty
engineering
with
crucial
structural/compositional
characteristics
satisfying
strict
requirements.
Herein,
address
this
Gordian
knot,
facile
strategy
intercalate
delaminate
Bi
bulk
generating
mass
few‐layered
yield
by
employing
water
molecule
mediated
freezing–thawing
process
sodium
borohydride‐triggered
reduction
treatment
is
proposed.
The
resulting
displays
good
performance
near‐infrared
(NIR)
biowindow
can
be
excited
via
red
light
reactive
oxygen
species
generation,
enabling
applications
multiple
photonic
cancer
settings,
including
photothermal
hyperthermia
photodynamic
therapy.
Utilizing
intrinsic
desirable
absorbance
strong
X‐ray
attenuation
bismuthene,
dual
therapy
conducted
under
supervision
photoacoustic/computed
tomography
guided
multimodal
imaging.
This
only
offers
mass‐production
ready,
cost‐effective,
eco‐efficient
methodology
Xenes,
but
also
exploits
an
innovative
based
nanomedicine.
Nano Letters,
Год журнала:
2019,
Номер
19(6), С. 4134 - 4145
Опубликована: Май 14, 2019
As
a
noninvasive
treatment
modality,
ultrasound
(US)-triggered
sonodynamic
therapy
(SDT)
shows
broad
and
promising
applications
to
overcome
the
drawbacks
of
traditional
photodynamic
(PDT)
in
combating
cancer.
However,
SDT
efficacy
is
still
not
satisfactory
without
oxygen
(O2)
assistance.
In
addition,
there
also
much
space
explore
SDT-based
synergistic
therapeutic
modalities.
Herein,
novel
Pt-CuS
Janus
composed
hollow
semiconductor
CuS
noble
metallic
Pt
was
rationally
designed
successfully
synthesized.
The
large
inner
cavity
for
loading
sonosensitizer
molecules
(tetra-(4-aminophenyl)
porphyrin,
TAPP)
implement
SDT.
Moreover,
deposition
only
enhances
photothermal
performance
compared
with
those
nanoparticles
(NPs)
due
effect
local
electric
field
enhancement
but
possesses
nanozyme
activity
catalyzing
decomposition
endogenous
overexpressed
hydrogen
peroxide
(H2O2)
produce
O2
that
can
tumor
hypoxia
augment
SDT-induced
highly
toxic
reactive
species
(ROS)
production
efficient
cancer
cell
apoptosis.
Importantly,
generated
heat
by
808
nm
laser
irradiation
accelerate
catalytic
elevate
level
further
facilitates
efficacy.
Interestingly,
thermally
sensitive
copolymer
coated
around
act
as
smart
switch
regulate
ability
control
TAPP
release
has
significant
on
modulating
effect.
catalysis-enhanced
efficiency
almost
realized
complete
resection
obvious
reoccurrence
simultaneously
displayed
biosafety.
Furthermore,
high
optical
absorbance
allows
as-synthesized
photoacoustic
(PA)
imaging
NIR
thermal
imaging.
This
work
develops
versatile
nanoplatform
multifunctional
theranostic
strategy
broadens
biological
designing
their
structure.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(4), С. 1253 - 1321
Опубликована: Янв. 1, 2020
Bismuth-containing
nanomaterials
offer
a
new
opportunity
to
move
beyond
current
achievements
in
the
fields
of
drug
delivery,
diagnosis,
cancer
therapy,
biosensing,
and
tissue
engineering.
This
review
describes
emerging
applications
perspective
these
nanoparticles.
Chemical Society Reviews,
Год журнала:
2019,
Номер
48(11), С. 3073 - 3101
Опубликована: Янв. 1, 2019
X-rays
are
widely
applied
in
clinical
medical
facilities
for
radiotherapy
(RT)
and
biomedical
imaging.
However,
the
sole
use
of
cancer
treatment
leads
to
insufficient
radiation
energy
deposition
due
low
X-ray
attenuation
coefficients
living
tissues
organs,
producing
unavoidable
excessive
doses
with
serious
side
effects
healthy
body
parts.
Over
past
decade,
developments
materials
science
nanotechnology
have
led
rapid
progress
field
X-ray-activated
tumor-targeting
nanosystems,
which
able
tackle
even
systemic
tumors
relieve
burden
exposure
large
doses.
Additionally,
novel
imaging
contrast
agents
techniques
also
been
developed.
In
comparison
conventional
external
light
sources
(e.g.,
near
infrared),
technique
is
ideal
activation
nanosystems
applications
its
nearly
unlimited
penetration
depth
organisms.
this
review,
we
systematically
describe
interaction
mechanisms
between
provide
an
overview
X-ray-sensitive
recent
on
cancer-associated
theranostic
applications.
Nano Letters,
Год журнала:
2019,
Номер
19(10), С. 6772 - 6780
Опубликована: Сен. 9, 2019
Light-sensitive
yolk–shell
nanoparticles
(YSNs)
as
remote-controlled
and
stimuli-responsive
theranostic
platforms
provide
an
attractive
method
for
synergistic
cancer
therapy.
Herein,
a
kind
of
novel
multifunctional
YSNs
has
been
successfully
constructed
by
integrating
star-shaped
gold
(Au
star)
the
second
near-infrared
(NIR-II)
photothermal
yolks
biodegradable
crystalline
zeolitic
imidazolate
framework-8
(ZIF-8)
shells.
In
this
platform,
chemotherapeutic
drug
(doxorubicin
hydrochloride,
DOX)
was
encapsulated
into
cavity,
which
can
show
behavior
controlled
release
due
to
degradation
process
ZIF-8
in
mildly
acidic
tumor
microenvironment.
Upon
1064
nm
(NIR-II
biowindow)
laser
irradiation,
nanostar@ZIF-8
(Au@MOF)
exhibited
outstanding
anticancer
effect
based
on
their
promoted
cargo
properties.
Moreover,
strong
NIR
region
absorbance
endows
Au@MOF
thermal
imaging
photoacoustic
(PA)
This
work
contributes
design
"all-in-one"
nanocarrier
that
realizes
bimodal
diagnosis
chemo-photothermal
ACS Nano,
Год журнала:
2023,
Номер
17(9), С. 7953 - 7978
Опубликована: Апрель 18, 2023
Hydrogels,
as
one
of
the
most
feasible
soft
biomaterials,
have
gained
considerable
attention
in
therapeutic
applications
by
virtue
their
tunable
properties
including
superior
patient
compliance,
good
biocompatibility
and
biodegradation,
high
cargo-loading
efficiency.
However,
hydrogel
application
is
still
limited
some
challenges
like
inefficient
encapsulation,
easy
leakage
loaded
cargoes,
lack
controllability.
Recently,
nanoarchitecture-integrated
systems
were
found
to
be
therapeutics
with
optimized
properties,
extending
bioapplication.
In
this
review,
we
briefly
presented
category
hydrogels
according
synthetic
materials
further
discussed
advantages
Additionally,
various
nanoarchitecture
hybrid
biomedical
engineering
are
systematically
summarized,
cancer
therapy,
wound
healing,
cardiac
repair,
bone
regeneration,
diabetes
obesity
therapy.
Last,
current
challenges,
limitations,
future
perspectives
development
flexible
addressed.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2020,
Номер
12(6)
Опубликована: Май 22, 2020
Abstract
X‐ray
imaging
is
the
most
widely
used
diagnostic
method
in
modern
medicine
and
several
advanced
forms
of
this
technology
have
recently
emerged.
Iodinated
molecules
barium
sulfate
suspensions
are
clinically
approved
contrast
agents
used.
However,
these
existing
provide
limited
information,
suboptimal
for
new
techniques
developing
safety
concerns.
Thus,
over
past
15
years,
there
has
been
a
rapid
growth
development
nanoparticles
as
agents.
Nanoparticles
desirable
features
such
high
payloads,
potential
long
circulation
times,
tunable
physicochemical
properties.
also
range
biomedical
applications
disease
treatment,
targeted
imaging,
cell
tracking.
In
review,
we
discuss
principles
behind
generation
introduce
types
modalities,
well
elements
chemical
compositions
that
suitable
novel
agent
development.
We
focus
on
progress
nanoparticle
developed
to
be
renally
clearable,
circulating,
theranostic,
targeted,
or
feature
conjunction
with
newly
multi‐energy
computed
tomography
mammographic
technologies.
Finally,
offer
perspectives
current
limitations
emerging
research
topics
expectations
future
field.
This
article
categorized
under:
Diagnostic
Tools
>
vivo
Nanodiagnostics
Imaging
Nanotechnology
Approaches
Biology
Nanoscale
Systems
ACS Applied Materials & Interfaces,
Год журнала:
2019,
Номер
11(43), С. 39503 - 39512
Опубликована: Окт. 3, 2019
Covalent
organic
frameworks
(COFs)
have
received
considerable
interest
because
of
their
advanced
applications.
However,
low
dispersibility
and
aqueous
stability
are
intractable
issues
limiting
biomedical
application.
To
address
the
issue,
water-dispersible
nanocomposites
(COF@IR783)
produced
through
assembly
cyanines
COFs
proposed
prepared.
Therefore,
a
strategy
"killing
three
birds
with
one
stone"
is
developed.
First,
exhibit
superior
compared
to
COFs.
The
nanosized
morphology
negative
charges,
which
in
favor
improving
blood
circulation
enhanced
permeability
retention-mediated
tumor-targeting
delivery
therapy
for
vivo
Second,
photothermal
(PTT)
ability
near-infrared
region
cyanines.
also
photoacoustic
imaging
ability,
can
guide
antitumor
vivo.
Lastly,
be
further
used
as
drug-delivery
carriers
loading
anticancer
cis-aconityl-doxorubicin
(CAD)
prodrug.
In
comparison
individual
PTT
or
chemotherapy,
combination
chemotherapy
achieved
COF@IR783@CAD
synergistically
induced
death
cancer
cells
vitro,
an
intravenous
injection
mice
resulted
significant
tumor
ablation.
This
work
indicates
that
appropriately
overcome
rational
design
expand
applications
