Metal Halide Perovskites for X-ray Imaging Scintillators and Detectors

ACS Energy Letters, Год журнала: 2021, Номер 6(2), С. 739 - 768

Опубликована: Янв. 29, 2021

Radiation detection, using materials to convert high-energy photons low-energy (X-ray imaging) or electrical charges detector), has become essential for a wide range of applications including medical diagnostic technologies, computed tomography, quality inspection and security, etc. Metal halide perovskite-based high-resolution scintillation-imaging screens direct conversion detectors are promising candidates such applications, because they have high absorption cross sections X-rays due their heavy atom (e.g., Pb2+, Bi3+, I–) compositions; moreover, these solution-processable at low temperature, possessing tunable bandgaps, near-unity photoluminescence quantum yields, trap density, charge carrier mobility, fast photoresponse. In this review, we explore decipher the working mechanism scintillators as well key advantages perovskites both detection approaches. We further discuss recent advancements in research area, pointing out remaining challenges our perspective future directions toward X-ray applications.

Язык: Английский

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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Фев. 17, 2023

Abstract Having a hypoxic microenvironment is common and salient feature of most solid tumors. Hypoxia has profound effect on the biological behavior malignant phenotype cancer cells, mediates effects chemotherapy, radiotherapy, immunotherapy through complex mechanisms, closely associated with poor prognosis in various patients. Accumulating studies have demonstrated that normalization tumor vasculature, nanoparticle carriers biocarriers can effectively increase oxygen concentration microenvironment, improve drug delivery efficacy radiotherapy. They also infiltration innate adaptive anti-tumor immune cells to enhance immunotherapy. Furthermore, drugs targeting key genes hypoxia, including hypoxia tracers, hypoxia-activated prodrugs, hypoxia-inducible factors downstream targets, be used for visualization quantitative analysis antitumor activity. However, relationship between an area research requires further exploration. Here, we investigated potential development cancer, changes signaling pathways occur adapt environments, mechanisms hypoxia-induced tolerance, chemotherapeutic enhanced radiation as well insights applications therapy.

Язык: Английский

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X-ray-activated persistent luminescence nanomaterials for NIR-II imaging

Nature Nanotechnology, Год журнала: 2021, Номер 16(9), С. 1011 - 1018

Опубликована: Июнь 10, 2021

Язык: Английский

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Organic phosphors with bright triplet excitons for efficient X-ray-excited luminescence

Nature Photonics, Год журнала: 2021, Номер 15(3), С. 187 - 192

Опубликована: Янв. 11, 2021

Язык: Английский

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Rare-earth-containing perovskite nanomaterials: design, synthesis, properties and applications

Chemical Society Reviews, Год журнала: 2020, Номер 49(4), С. 1109 - 1143

Опубликована: Янв. 1, 2020

As star material, perovskites have been widely used in the fields of optics, photovoltaics, electronics, magnetics, catalysis, sensing, etc. However, some inherent shortcomings, such as low efficiency (power conversion efficiency, external quantum etc.) and poor stability (against water, oxygen, ultraviolet light, etc.), limit their practical applications. Downsizing materials into nanostructures incorporating rare earth (RE) ions are effective means to improve properties broaden This review will systematically summarize key points design, synthesis, property improvements application expansion RE-containing (including both RE-based RE-doped) halide oxide perovskite nanomaterials (PNMs). The critical factors RE elements different structures rational design functional be discussed detail. advantages disadvantages synthesis methods for PNMs reviewed. paper also experiences selecting suitable designing multi-functional according mechanisms principles REs promoting perovskites. At end this review, we provide an outlook on opportunities challenges various fields.

Язык: Английский

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Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

ACS Nano, Год журнала: 2020, Номер 14(3), С. 2585 - 2627

Опубликована: Фев. 7, 2020

Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most currently available diagnosis and therapies are invasive, time-consuming, associated with severe toxic side effects. Nanotheranostics, on other hand, has potential to bridge this gap by harnessing capabilities nanotechnology nanomaterials for combined therapeutics diagnostics markedly enhanced efficacy. However, nanomaterial applications nanotheranostics still its infancy. This due fact that each disease a particular microenvironment well-defined characteristics, which promotes deeper selection criteria meet needs. In review, we have outlined how designed tailored cancer diseases such as neurodegenerative, autoimmune (particularly rheumatoid arthritis), cardiovascular diseases. The penetrability retention biological system, therapeutic strategy used, imaging mode selected some aspects discussed disease. specific properties terms feasibility, physicochemical challenges, progress clinical trials, toxicity, their future application translational medicine addressed. Our review meticulously critically examines various nanomaterials, including graphene, across several diseases, offering broader perspective emerging field.

Язык: Английский

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Photodynamic Therapy: A Compendium of Latest Reviews

Cancers, Год журнала: 2021, Номер 13(17), С. 4447 - 4447

Опубликована: Сен. 3, 2021

Photodynamic therapy (PDT) is a promising against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present brief compendium of reviews decades classified under different topics, namely, overviews, about specific cancers, and meta-analyses photosensitisers, PDT mechanisms, dosimetry, light sources. The key issues main conclusions are summarized, including ways means to improve outcomes. Due broad scope work being first time that latest performed PDT, may be interest wide audience.

Язык: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Год журнала: 2021, Номер 15(4), С. 6147 - 6191

Опубликована: Март 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Язык: Английский

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Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Advanced Science, Год журнала: 2021, Номер 9(5)

Опубликована: Дек. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Язык: Английский

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Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 32(50)

Опубликована: Ноя. 9, 2020

Chemotherapy causes off-target toxicity and is often ineffective against solid tumors. Targeted on-demand release of chemotherapeutics remains a challenge. Here, cancer-cell-membrane-coated mesoporous organosilica nanoparticles (MONs) containing X-ray- reactive oxygen species (ROS)-responsive diselenide bonds for controlled doxorubicin (DOX) at tumor sites are developed. DOX-loaded MONs coated with 4T1 breast cancer cell membranes (CM@MON@DOX) show greater accumulation prolonged blood circulation time versus an uncoated control in mice bearing orthotopic mammary Under low-dose X-ray radiation, the exhibit carrier degradation-controlled via cleavage bonds, resulting DOX-mediated immunogenic death site. Combination PD-L1 checkpoint blockade further enhances inhibition growth metastasis low systemic toxicity. Together, findings promise these biomimetic, radiation-responsive diselenide-bond-bridged chemo-immunotherapy.

Язык: Английский

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