Advanced Materials,
Год журнала:
2019,
Номер
31(49)
Опубликована: Сен. 19, 2019
Surgical
resection
is
the
primary
and
most
effective
treatment
for
patients
with
solid
tumors.
However,
suffer
from
postoperative
recurrence
metastasis.
In
past
years,
emerging
nanotechnology
has
led
way
to
minimally
invasive,
precision
intelligent
oncological
surgery
after
rapid
development
of
invasive
surgical
technology.
Advanced
in
construction
nanomaterials
(NMs)
imaging-guided
(IGS)
as
well
surgery-assisted
synergistic
therapy
summarized,
thereby
unlocking
advantages
multimodal
IGS-assisted
cancer
therapy.
First,
mechanisms
principles
NMs
targets
are
briefly
introduced.
Multimodal
imaging
based
on
molecular
technologies
provides
a
practical
method
achieve
intraoperative
visualization
high
resolution
deep
tissue
penetration.
Moreover,
multifunctional
synergize
adjuvant
(e.g.,
chemotherapy,
immunotherapy,
phototherapy)
eliminate
residual
lesions.
Finally,
key
issues
ideal
theranostic
associated
applications
challenges
clinical
transformation
discussed
push
forward
further
Chemical Society Reviews,
Год журнала:
2020,
Номер
50(2), С. 1111 - 1137
Опубликована: Ноя. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
Advanced Materials,
Год журнала:
2020,
Номер
32(47)
Опубликована: Окт. 16, 2020
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT),
as
a
promising
noninvasive
therapeutic
modality,
has
received
ever-increasing
attention
in
recent
years.
Its
specialized
chemical
agents,
named
sonosensitizers,
are
activated
by
low-intensity
US
to
produce
lethal
reactive
oxygen
species
(ROS)
for
oncotherapy.
Compared
with
phototherapeutic
strategies,
SDT
provides
many
noteworthy
opportunities
and
benefits,
such
deeper
penetration
depth,
absence
of
phototoxicity,
fewer
side
effects.
Nevertheless,
previous
studies
have
also
demonstrated
its
intrinsic
limitations.
Thanks
the
facile
engineering
nature
nanotechnology,
numerous
novel
nanoplatforms
being
applied
this
emerging
field
tackle
these
barriers
achieve
continuous
innovations.
In
particular,
combination
other
treatment
strategies
superior
efficacy
improving
anticancer
activity
relative
that
monotherapies
alone.
Therefore,
it
is
necessary
summarize
nanomaterial-assisted
combinational
cancer
applications.
Herein,
design
principles
achieving
synergistic
effects
based
on
nanomaterial
methods
highlighted.
The
ultimate
goals
stimulate
better-quality
combined
schemes
provide
innovative
ideas
perspectives
promoting
future
transformation
clinical
application.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(14), С. 6527 - 6537
Опубликована: Март 19, 2020
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT)
that
enables
noninvasive
treatment
of
large
internal
tumors
has
attracted
widespread
interest.
For
improvement
in
the
therapeutic
responses
to
SDT,
more
effective
and
stable
sonosensitizers
are
still
required.
Herein,
ultrafine
titanium
monoxide
nanorods
(TiO1+x
NRs)
with
greatly
improved
sono-sensitization
Fenton-like
catalytic
activity
were
fabricated
used
for
enhanced
SDT.
TiO1+x
NRs
an
rodlike
structure
successfully
prepared
then
modified
polyethylene
glycol
(PEG).
Compared
conventional
sonosensitizer,
TiO2
nanoparticles,
PEG–TiO1+x
resulted
much
efficient
US-induced
generation
reactive
oxygen
species
(ROS)
because
oxygen-deficient
NR,
which
predominantly
serves
as
charge
trap
limit
recombination
US-triggered
electron–hole
pairs.
Interestingly,
also
exhibit
horseradish-peroxidase-like
nanozyme
can
produce
hydroxyl
radicals
(•OH)
from
endogenous
H2O2
tumor
enable
chemodynamic
(CDT).
Because
their
passive
retention
post
intravenous
injection,
be
a
sonosensitizer
CDT
agent
highly
ablation
under
US
treatment.
In
addition,
no
significant
long-term
toxicity
was
found
treated
mice.
This
work
highlights
new
type
titanium-based
nanostructure
great
performance
Nano-Micro Letters,
Год журнала:
2021,
Номер
13(1)
Опубликована: Июль 9, 2021
Since
the
ferromagnetic
(Fe3O4)
nanoparticles
were
firstly
reported
to
exert
enzyme-like
activity
in
2007,
extensive
research
progress
nanozymes
has
been
made
with
deep
investigation
of
diverse
and
rapid
development
related
nanotechnologies.
As
promising
alternatives
for
natural
enzymes,
have
broadened
way
toward
clinical
medicine,
food
safety,
environmental
monitoring,
chemical
production.
The
past
decade
witnessed
metal-
metal
oxide-based
owing
their
remarkable
physicochemical
properties
parallel
low
cost,
high
stability,
easy
storage.
It
is
widely
known
that
study
catalytic
activities
mechanism
sheds
significant
influence
on
applications
nanozymes.
This
review
digs
into
characteristics
intrinsic
nanozymes,
especially
emphasizing
recent
biological
analysis,
relieving
inflammation,
antibacterial,
cancer
therapy.
We
also
conclude
present
challenges
provide
insights
future
constituted
oxide
nanomaterials.
ACS Nano,
Год журнала:
2020,
Номер
14(2), С. 2063 - 2076
Опубликована: Фев. 5, 2020
Ultrasound
(US)-driven
sonodynamic
therapy
(SDT)
has
demonstrated
wide
application
prospects
in
the
eradication
of
deep-seated
bacterial
infections
due
to
its
noninvasiveness,
site-confined
irradiation,
and
high-tissue-penetrating
capability.
However,
ineffective
accumulation
sonosensitizers
at
infection
site,
hypoxic
microenvironment,
as
well
rapid
depletion
oxygen
during
SDT
greatly
hamper
therapeutic
efficacy
SDT.
Herein,
an
US-switchable
nanozyme
system
was
proposed
for
controllable
generation
catalytic
sonosensitizer-mediated
reactive
species
ultrasound
activation,
thereby
alleviating
hypoxia-associated
barrier
augmenting
efficacy.
This
nanoplatform
(Pd@Pt-T790)
easily
prepared
by
bridging
enzyme-catalytic
Pd@Pt
nanoplates
with
organic
sonosensitizer
meso-tetra(4-carboxyphenyl)porphine
(T790).
It
really
interesting
find
that
modification
T790
onto
could
significantly
block
catalase-like
activity
Pd@Pt,
whereas
upon
US
effectively
recovered
catalyze
decomposition
endogenous
H2O2
into
O2.
Such
"blocking
activating"
enzyme
particularly
important
decreasing
potential
toxicity
side
effects
nanozymes
on
normal
tissues
realize
active,
controllable,
disease-loci-specific
behavior.
Taking
advantage
this
activity,
outstanding
sites,
excellent
biocompatibility,
Pd@Pt-T790-based
nanosystem
successfully
applied
eradicate
methicillin-resistant
Staphylococcus
aureus
(MRSA)-induced
myositis,
progression
noninvasively
monitored
photoacoustic
imaging
magnetic
resonance
imaging.
The
developed
nanoenzyme
provides
a
promising
strategy
actively,
controllably,
precisely.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(22)
Опубликована: Март 8, 2021
Abstract
Triggered
by
the
endogenous
chemical
energy
in
tumor
microenvironment
(TME),
chemodynamic
therapy
(CDT)
as
an
emerging
non‐exogenous
stimulant
therapeutic
modality
has
received
increasing
attention
recent
years.
The
agents
can
convert
internal
hydrogen
peroxide
(H
2
O
)
into
lethal
reactive
oxygen
species
(ROS)
hydroxyl
radicals
(
•
OH)
for
oncotherapy.
Compared
with
other
modalities,
CDT
possesses
many
notable
advantages,
such
tumor‐specific,
highly
selective,
fewer
systemic
side
effects,
and
no
need
external
stimulation.
Nevertheless,
mild
acid
pH,
low
H
content,
overexpressed
reducing
substance
TME
severely
suppressed
efficiency.
With
rapid
development
of
nanotechnology,
some
kinds
nanomaterials
have
been
utilized
improved
In
particular,
excellent
photo‐,
ultrasound‐,
magnetic‐,
stimuli‐response
properties
make
it
possible
combination
cancer
shown
superior
anti‐cancer
activity
than
monotherapies.
Therefore,
is
necessary
to
summarize
application
nanomaterial‐based
therapy.
this
review,
various
nanomaterials‐based
nanoplatforms
its
combinational
therapies
are
summarized
discussed,
aiming
provide
inspiration
design
better‐quality
promote
lay
foundation
future
conversion
clinical
applications.
Nano Letters,
Год журнала:
2019,
Номер
19(8), С. 5674 - 5682
Опубликована: Июль 30, 2019
The
efficiency
of
chemical
intercommunication
between
enzymes
in
natural
networks
can
be
significantly
enhanced
by
the
organized
catalytic
cascades.
Nevertheless,
exploration
two-or-more-enzymes-engineered
nanoreactors
for
cascades
remains
a
great
challenge
cancer
therapy
because
inherent
drawbacks
enzymes.
Here,
encouraged
activity
individual
nanozyme
benefiting
treatment
solid
tumors,
we
propose
an
situ
cascades-enhanced
synergistic
therapeutic
strategy
driven
dual-nanozymes-engineered
porphyrin
metal–organic
frameworks
(PCN).
Precisely,
catalase-mimicking
platinum
nanoparticles
(Pt
NPs)
were
sandwiched
PCN,
followed
embedding
glucose
oxidase-mimicking
ultrasmall
gold
(Au
within
outer
shell,
and
further
coordination
with
folic
acid
(P@Pt@P–Au–FA).
Pt
NPs
effectively
enabled
tumor
hypoxia
relief
catalyzing
intratumoral
H2O2
to
O2
(1)
enhancing
O2-dependent
photodynamic
(2)
subsequently
accelerating
depletion
β-d-glucose
Au
starving-like
self-produced
as
substrate
NPs.
Consequently,
remarkably
strengthened
antitumor
prevention
recurrence
metastasis
was
achieved.
This
work
highlights
rationally
designed
microenvironment-specific
nanoreactor
opening
improved
research
nanozymes
provides
means
design
cascade
model
practical
applications.
Nano Letters,
Год журнала:
2019,
Номер
19(10), С. 6772 - 6780
Опубликована: Сен. 9, 2019
Light-sensitive
yolk–shell
nanoparticles
(YSNs)
as
remote-controlled
and
stimuli-responsive
theranostic
platforms
provide
an
attractive
method
for
synergistic
cancer
therapy.
Herein,
a
kind
of
novel
multifunctional
YSNs
has
been
successfully
constructed
by
integrating
star-shaped
gold
(Au
star)
the
second
near-infrared
(NIR-II)
photothermal
yolks
biodegradable
crystalline
zeolitic
imidazolate
framework-8
(ZIF-8)
shells.
In
this
platform,
chemotherapeutic
drug
(doxorubicin
hydrochloride,
DOX)
was
encapsulated
into
cavity,
which
can
show
behavior
controlled
release
due
to
degradation
process
ZIF-8
in
mildly
acidic
tumor
microenvironment.
Upon
1064
nm
(NIR-II
biowindow)
laser
irradiation,
nanostar@ZIF-8
(Au@MOF)
exhibited
outstanding
anticancer
effect
based
on
their
promoted
cargo
properties.
Moreover,
strong
NIR
region
absorbance
endows
Au@MOF
thermal
imaging
photoacoustic
(PA)
This
work
contributes
design
"all-in-one"
nanocarrier
that
realizes
bimodal
diagnosis
chemo-photothermal
