Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(30), С. 16294 - 16308

Опубликована: Авг. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Язык: Английский

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J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Journal of the American Chemical Society, Год журнала: 2019, Номер 141(49), С. 19221 - 19225

Опубликована: Ноя. 20, 2019

Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution vivo optical bioimaging due to decreased scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed improve around it is still a great challenge synthesize organic molecules with absorption emission toward this region. Here, we present J-aggregates 1360 nm 1370 formed by self-assembly of amphiphilic cyanine dye FD-1080 1,2-dimyristoyl-sn-glycero-3-phosphocholine. Molecular dynamics simulations were further employed illustrate process. Superior spatial resolution high signal-to-background ratio demonstrated noninvasive brain hindlimb vasculature nm. The efficacy evaluation clinically used hypotensor successfully achieved dynamic vascular imaging J-aggregates.

Язык: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

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Near-infrared luminescence high-contrast in vivo biomedical imaging

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(1), С. 60 - 78

Опубликована: Янв. 19, 2023

Язык: Английский

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All-in-One Theranostic Nanomedicine with Ultrabright Second Near-Infrared Emission for Tumor-Modulated Bioimaging and Chemodynamic/Photodynamic Therapy

ACS Nano, Год журнала: 2020, Номер 14(8), С. 9613 - 9625

Опубликована: Авг. 10, 2020

Reactive oxygen species (ROS)-based therapeutic modalities including chemodynamic therapy (CDT) and photodynamic (PDT) hold great promise for conquering malignant tumors. However, these two methods tend to be restricted by the overexpressed glutathione (GSH) hypoxia in tumor microenvironment (TME). Here, we develop biodegradable copper/manganese silicate nanosphere (CMSN)-coated lanthanide-doped nanoparticles (LDNPs) trimodal imaging-guided CDT/PDT synergistic therapy. The tridoped Yb3+/Er3+/Tm3+ ultrasmall core optimal Yb3+/Ce3+ doping shell enable ultrabright dual-mode upconversion (UC) downconversion (DC) emissions of LDNPs under near-infrared (NIR) laser excitation. luminescence second (NIR-II, 1000-1700 nm) window offers deep-tissue penetration, high spatial resolution, reduced autofluorescence when used optical imaging. Significantly, CMSNs are capable relieving hypoxic TME through decomposing H2O2 produce O2, which can react with sample generate 1O2 upon excitation UC photons (PDT). GSH-triggered degradation results release Fenton-like Mn2+ Cu+ ions •OH generation (CDT); simultaneously, released couple NIR-II imaging, computed tomography (CT) magnetic resonance (MR) imaging LDNPs, performing a TME-amplified effect. In such nanomedicine, modulation, bimetallic photosensitizer, nanocatalyst, NIR-II/MR/CT contrast agent were achieved "one all", thereby realizing highly efficient theranostics.

Язык: Английский

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Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

ACS Nano, Год журнала: 2020, Номер 14(10), С. 13536 - 13547

Опубликована: Сен. 14, 2020

Killing tumor cells with a visualized system is promising strategy in therapy to achieve minimal side effects and high efficiency. Herein, theranostic nanomedicine (AuNCs-Pt) developed based on nanocarrier gold nanoclusters (AuNCs) bifunctions of both NIR-I/NIR-II imaging glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II capability fatal high-grade serous ovarian cancer (HGSOC) model the deep abdomen, thus facilitating it be tool for monitoring platinum transportation. Meanwhile, depletes intracellular glutathione minimize detoxification, effectively maximizing chemotherapeutic efficacy platinum. used eradicate burden this study HGSOC patient-derived xenograft hepatocellular carcinoma, suggesting great potential clinical drug sensitization.

Язык: Английский

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Molecular Fluorophores for Deep-Tissue Bioimaging

ACS Central Science, Год журнала: 2020, Номер 6(8), С. 1302 - 1316

Опубликована: Июль 23, 2020

Fluorescence imaging has made tremendous inroads toward understanding the complexity of biological systems, but in vivo deep-tissue remains a great challenge due to optical opacity tissue. Recent improvements laser and detector manufacturing have allowed expansion nonlinear linear fluorescence underexplored "tissue-transparent" second near-infrared (NIR-II; 1000–1700 nm) window, opening up new opportunities for access deep inside opaque Molecular fluorophores historically played major role bioimaging. It is increasingly important design molecular fully unlock potential NIR-II techniques. In this outlook, we give an overview novel developed bioimaging past five years discuss their pros cons applications. Guidelines designing with desirable properties are also provided.

Язык: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Год журнала: 2021, Номер 15(4), С. 6147 - 6191

Опубликована: Март 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Язык: Английский

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NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

Advanced Functional Materials, Год журнала: 2021, Номер 31(32)

Опубликована: Июнь 10, 2021

Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both academic and clinical fields. This review summarizes categories, structures, conversion properties time. synergistic strategies responsive combined other approaches including chemotherapy, chemodynamic therapy, photodynamic radiotherapy are summarized. future challenges perspectives on these systems construction discussed.

Язык: Английский

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Multiexcitonic Emission in Zero-Dimensional Cs₂ZrCl₆:Sb³⁺ Perovskite Crystals

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(42), С. 17599 - 17606

Опубликована: Окт. 13, 2021

Metal halide perovskites are highly attractive for lighting applications, but the multiexcitonic emission processes in these crystals largely unexplored. This study presents an investigation of Sb3+-doped Cs2ZrCl6 perovskite that display double luminescence due to intrinsic host self-trapped excitons (denoted as STEs) and dopant-induced extrinsic dopant STEs), respectively. Steady-state transient-state spectroscopy reveal STEs can be independently charged at specific energies. Density functional theory calculations confirm stems from minimal interactions between zero-dimensional crystal lattice. By selective excitation different through precise control wavelength, we further demonstrate dynamic color tuning Cs2ZrCl6:Sb3+ crystals. The kinetic feature offers exciting opportunities constructing multicolor light-emitting devices encrypting multilevel optical codes.

Язык: Английский

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