Near-infrared luminescence high-contrast in vivo biomedical imaging

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(1), С. 60 - 78

Опубликована: Янв. 19, 2023

Язык: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Год журнала: 2021, Номер 61(14)

Опубликована: Дек. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Язык: Английский

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Precision Navigation of Hepatic Ischemia–Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-II Fluorescence

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(30), С. 13586 - 13599

Опубликована: Июль 6, 2022

Hepatic ischemia–reperfusion injury (HIRI) is responsible for postoperative liver dysfunction and failure. Precise rapid navigation of HIRI lesions critical early warning timely development pretreatment plans. Available methods assaying fail to provide the exact location in real time intraoperatively. intimately associated with oxidative stress which impairs lysosomal degradative function, leading significant changes viscosity. Therefore, viscosity a potential biomarker precise targeting HIRI. Hence, we developed viscosity-activatable second near-infrared window fluorescent probe (NP-V) detection hepatocytes mice during A reactive oxygen species–malondialdehyde–cathepsin B signaling pathway was established. We further conducted high signal-to-background ratio NIR-II fluorescence imaging mice. The contour boundary were delineated, as such intraoperative resection lesion area implemented. This research demonstrates NP-V dual-functional elucidation pathogenesis direct clinical applications.

Язык: Английский

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Brain‐Targeted Aggregation‐Induced‐Emission Nanoparticles with Near‐Infrared Imaging at 1550 nm Boosts Orthotopic Glioblastoma Theranostics

Advanced Materials, Год журнала: 2021, Номер 34(5)

Опубликована: Окт. 29, 2021

A remaining challenge in the treatment of glioblastoma multiforme (GBM) is surmounting blood-brain barrier (BBB). Such a prevents development efficient theranostic approaches that combine reliable diagnosis with targeted therapy. In this study, brain-targeted near-infrared IIb (NIR-IIb) aggregation-induced-emission (AIE) nanoparticles are developed via rational design, which involves twisting planar molecular backbone steric hindrance. The resulting can balance competing responsiveness demands for radiation-mediated NIR fluorescence imaging at 1550 nm and non-radiation photothermal therapy (NIR-PTT). brain-targeting peptide apolipoprotein E (ApoE) grafted onto these (termed as ApoE-Ph NPs) to target glioma promote BBB traversal. long wavelength band-pass filter utilized monitor vivo biodistribution accumulation model orthotopic glioma, overcomes previous limitations range equipment. results demonstrate NPs have higher PTT efficiency significantly enhanced survival mice bearing GBM moderate irradiation (0.5 W cm-2 ). Collectively, work highlights smart design NIR-II AIE approach opens new options photonic GBM.

Язык: Английский

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Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

Small Methods, Год журнала: 2021, Номер 5(3)

Опубликована: Янв. 18, 2021

Near-infrared (NIR) fluorescence imaging is an emerging noninvasive modality, with unique advantages in guiding tumor resection surgery, thanks to its high sensitivity and instantaneity. In the past decade, studies on conventional NIR window (NIR-I, 750-900 nm) have gradually focused second (NIR-II, 1000-1700 nm). With reduced light scattering, photon absorption, auto-fluorescence qualities, NIR-II significantly improves penetration depths signal-to-noise ratios bio-imaging. Recently, several applied navigating cancer including localizing cancers, assessing surgical margins, tracing lymph nodes, mapping important anatomical structures. These exemplified significant prospects of this new approach. review, agents some complex applications for surgeries are summarized. Future challenges clinical translation also discussed.

Язык: Английский

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Stepping Out of the Blue: From Visible to Near‐IR Triggered Photoswitches

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(31)

Опубликована: Май 7, 2022

Abstract Light offers unique opportunities for controlling the activity of materials and biosystems with high spatiotemporal resolution. Molecular photoswitches are chromophores that undergo reversible isomerization between different states upon irradiation light, allowing a convenient means to control their influence over system interest. However, significant limitation classical is requirement initiate switching in one or both directions using deleterious UV light poor tissue penetration. Red‐shifted hence demand have attracted keen recent research In this Review, we highlight progress towards development visible‐ NIR‐activated characterized by distinct photochromic reaction mechanisms. We hope inspire further endeavors field, full potential these tools biotechnology chemistry applications be realized.

Язык: Английский

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Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(31), С. 14351 - 14362

Опубликована: Июль 29, 2022

Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, i.e., deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes bright, nontoxic, photostable, biocompatible, and easily derivatized to introduce functionalities (e.g., bioconjugation or aqueous solubility). The rational design of such remains a major challenge. Silicon-substituted rhodamines have been successful bioimaging applications red region. longer-wavelength silicon-substituted congeners unknown date. We successfully prepared four bis-benzannulated rhodamine (ESi5a–ESi5d), with an efficient five-step cascade on gram-scale. Because extensive overlapping their HOMO–LUMO orbitals, ESi5a–ESi5d highly (λabs ≈ 865 nm ε > 105 cm–1 M–1). By restraining both rotational freedom via annulation vibrational silicon-imparted strain, fluorochromic scaffold ESi5 is rigid, resulting unusually long fluorescence lifetime (τ 700 ps CH2Cl2) high quantum yield (ϕ = 0.14 CH2Cl2). Their half-lives toward photobleaching 2 orders magnitude longer than current standard (ICG serum). They stable presence biorelevant concentration nucleophiles reactive oxygen species. minimally toxic readily metabolized. Upon tail vein injection ESi5a (as example), vasculature nude mouse was imaged signal-to-background ratio. broad potentials

Язык: Английский

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Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 468, С. 214609 - 214609

Опубликована: Май 31, 2022

Язык: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114821 - 114821

Опубликована: Апрель 9, 2023

Язык: Английский

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NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(6), С. 449 - 467

Опубликована: Май 1, 2024

Язык: Английский

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