Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 21, 2024
Abstract
Cell
membrane‐coated
nanoparticles
(CMNPs)
have
recently
emerged
as
a
promising
platform
for
cancer
therapy.
By
encapsulating
therapeutic
agents
within
cell
membrane‐derived
coating,
these
combine
the
advantages
of
synthetic
and
natural
membranes.
This
review
provides
comprehensive
overview
recent
advancements
in
utilizing
CMNPs
effective
drug
delivery
vehicles
The
synthesis
fabrication
methods
are
comprehensively
discussed.
Various
techniques,
such
extrusion,
sonication,
self‐assembly,
employed
to
coat
with
membranes
derived
from
different
types.
membrane
coating
enables
biocompatibility,
reducing
risk
an
immune
response
enhancing
stability
bloodstream.
Moreover,
functionalization
strategies
CMNPs,
primarily
chemical
modification,
genetic
engineering,
external
stimuli,
highlighted.
presence
specific
surface
markers
on
coated
allows
targeted
cells
maximizes
efficacy.
Preclinical
studies
therapy
demonstrated
successful
various
agents,
chemotherapeutic
drugs,
nucleic
acids,
immunotherapeutic
using
CMNPs.
Furthermore,
article
explores
future
directions
challenges
this
technology
while
offering
insights
into
its
clinical
potential.
Small,
Journal Year:
2021,
Volume and Issue:
17(12)
Published: Feb. 12, 2021
Abstract
Nanotechnology
has
provided
great
opportunities
for
managing
neoplastic
conditions
at
various
levels,
from
preventive
and
diagnostic
to
therapeutic
fields.
However,
when
it
comes
clinical
application,
nanoparticles
(NPs)
have
some
limitations
in
terms
of
biological
stability,
poor
targeting,
rapid
clearance
the
body.
Therefore,
biomimetic
approaches,
utilizing
immune
cell
membranes,
are
proposed
solve
these
issues.
For
example,
macrophage
or
neutrophil
membrane
coated
NPs
developed
with
ability
interact
tumor
tissue
suppress
cancer
progression
metastasis.
The
functionality
particles
largely
depends
on
surface
proteins
cells
their
preserved
function
during
extraction
coating
process
NPs.
Proteins
outer
can
render
a
wide
range
activities
NPs,
including
prolonged
blood
circulation,
remarkable
competency
recognizing
antigens
enhanced
better
cellular
interactions,
gradual
drug
release,
reduced
toxicity
vivo.
In
this
review,
nano‐based
systems
cells‐derived
membranous
layers,
detailed
production
process,
applicability
treatment
discussed.
addition,
future
perspectives
challenges
translation
also
presented.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(14)
Published: Feb. 28, 2021
Abstract
Extracellular
vesicles
(EVs)
have
emerged
as
a
novel
cell‐free
strategy
for
the
treatment
of
many
diseases
including
cancer.
As
result
their
natural
properties
to
mediate
cell‐to‐cell
communication
and
high
physiochemical
stability
biocompatibility,
EVs
are
considered
excellent
delivery
vehicles
variety
therapeutic
agents
such
nucleic
acids
proteins,
drugs,
nanomaterials.
Increasing
studies
shown
that
can
be
modified,
engineered,
or
designed
improve
efficiency,
specificity,
safety
cancer
therapy.
Herein,
comprehensive
overview
recent
advances
in
strategies
methodologies
engineering
scalable
production
improved
cargo‐loading
tumor‐targeting
is
provided.
Additionally,
potential
applications
engineered
therapy
discussed
by
presenting
prominent
examples,
opportunities
challenges
translating
into
clinical
practice
evaluated.
Molecular Cancer,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Jan. 27, 2021
Abstract
Lung
cancer
is
often
diagnosed
at
an
advanced
stage
and
has
a
poor
prognosis.
Conventional
treatments
are
not
effective
for
metastatic
lung
therapy.
Although
some
of
molecular
targets
have
been
identified
with
favorable
response,
those
cannot
be
exploited
due
to
the
lack
suitable
drug
carriers.
cell-derived
exosomes
(LCCDEs)
receive
recent
interest
in
its
role
carcinogenesis,
diagnosis,
therapy,
prognosis
biological
functions
natural
ability
carry
donor
cell
biomolecules.
LCCDEs
can
promote
proliferation
metastasis,
affect
angiogenesis,
modulate
antitumor
immune
responses
during
regulate
resistance
now
considered
important
component
liquid
biopsy
assessments
detecting
cancer.
Therapeutic
deliverable
emerging
as
promising
delivery
agents
specifically
tumor
high
precision
medicine
because
their
intercellular
communication
role,
excellent
biocompatibility,
low
immunogenicity,
toxicity,
long
blood
circulation
ability,
biodegradable
characteristics,
cross
various
barriers.
Several
studies
currently
underway
develop
novel
diagnostic
prognostic
modalities
using
LCCDEs,
methods
exploiting
use
efficient
vehicles.
Current
status
extensive
applicability
illustrated
this
review.
The
data
technologies
indicate
that
approach
on
implies
potential
application
clinical
management
patients.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: April 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
ACS Applied Bio Materials,
Journal Year:
2019,
Volume and Issue:
3(1), P. 107 - 120
Published: Nov. 25, 2019
Microfluidic
technologies
with
precise
fluid
control
and
rapid
microscale
mixing
have
attracted
widespread
interest
in
the
fabrication
engineering
of
nanomaterials
for
drug
delivery.
The
drug-loaded
prepared
by
microfluidic
methods
can
exhibit
better
monodispersity,
higher
encapsulation
efficiency,
prolonged
blood
circulation
time
as
compared
to
those
conventional
bench
methods.
In
this
review,
we
summarize
recent
advances
a
variety
nanomaterials,
including
organic,
inorganic,
hybrid
nanoparticles,
delivery
systems.
We
discuss
physicochemical
properties
these
such
size,
shape,
structure,
rigidity,
surface
modification,
which
affect
their
therapeutic
efficacy
some
extent.
Furthermore,
perspective
targeted
is
presented.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 945 - 985
Published: Nov. 23, 2020
Cell
primitive-based
functional
materials
that
combine
the
advantages
of
natural
substances
and
nanotechnology
have
emerged
as
attractive
therapeutic
agents
for
cancer
therapy.
primitives
are
characterized
by
distinctive
biological
functions,
such
long-term
circulation,
tumor
specific
targeting,
immune
modulation
etc.
Moreover,
synthetic
nanomaterials
featuring
unique
physical/chemical
properties
been
widely
used
effective
drug
delivery
vehicles
or
anticancer
to
treat
cancer.
The
combination
these
two
kinds
will
catalyze
generation
innovative
biomaterials
with
multiple
high
biocompatibility
negligible
immunogenicity
precise
In
this
review,
we
summarize
most
recent
advances
in
development
cell
Different
primitives,
including
bacteria,
phages,
cells,
membranes,
other
bioactive
introduced
their
strategies
combining
materials,
especially
nanoparticulate
systems,
construction
function-enhanced
also
summarized.
Furthermore,
foreseeable
challenges
future
perspectives
included
research
direction
field.
Journal of Nanobiotechnology,
Journal Year:
2020,
Volume and Issue:
18(1)
Published: Aug. 20, 2020
Glucocorticoids
(GCs)
show
powerful
treatment
effect
on
rheumatoid
arthritis
(RA).
However,
the
clinical
application
is
limited
by
their
nonspecific
distribution
after
systemic
administration,
serious
adverse
reactions
during
long-term
administration.
To
achieve
better
treatment,
reduce
side
effect,
we
here
established
a
biomimetic
exosome
(Exo)
encapsulating
dexamethasone
sodium
phosphate
(Dex)
nanoparticle
(Exo/Dex),
whose
surface
was
modified
with
folic
acid
(FA)-polyethylene
glycol
(PEG)-cholesterol
(Chol)
compound
to
attain
FPC-Exo/Dex
active
targeting
drug
delivery
system.The
size
of
128.43
±
16.27
nm,
polydispersity
index
(PDI)
0.36
0.05,
and
Zeta
potential
-
22.73
0.91
mV.
The
encapsulation
efficiency
(EE)
preparation
10.26
0.73%,
loading
(DLE)
18.81
2.05%.
In
vitro
study
showed
this
system
displayed
enhanced
endocytosis
excellent
anti-inflammation
against
RAW264.7
cells
suppressing
pro-inflammatory
cytokines
increasing
anti-inflammatory
cytokine.
Further
biodistribution
fluorescence
intensity
stronger
than
other
Dex
formulations
in
joints,
suggesting
its
accumulation
inflammation
sites.
vivo
experiment
could
preserve
bone
cartilage
CIA
mice
significantly
inflamed
joints.
Next
safety
evaluation
demonstrated
had
no
obvious
hepatotoxicity
exhibited
desirable
biocompatibility.The
present
provides
promising
strategy
for
using
as
nanocarrier
enhance
therapeutic
GCs
RA.
