Gold nanoclusters for theranostic applications

Coordination Chemistry Reviews, Год журнала: 2020, Номер 431, С. 213689 - 213689

Опубликована: Дек. 5, 2020

Язык: Английский

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Gold Nanoparticles: Biosynthesis and Potential of Biomedical Application

Journal of Functional Biomaterials, Год журнала: 2021, Номер 12(4), С. 70 - 70

Опубликована: Дек. 3, 2021

Gold nanoparticles (AuNPs) are extremely promising objects for solving a wide range of biomedical problems. The gold production by biological method (“green synthesis”) is eco-friendly and allows minimization the amount harmful chemical toxic byproducts. This review devoted to AuNPs biosynthesis peculiarities using various living organisms (bacteria, fungi, algae, plants). participation biomolecules in synthesis influence size, shapes, capping agents on functionalities described. proposed action mechanisms target cells highlighted. activities “green” (antimicrobial, anticancer, antiviral, etc.) possibilities their further application also discussed.

Язык: Английский

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Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications

Bioconjugate Chemistry, Год журнала: 2021, Номер 33(1), С. 4 - 23

Опубликована: Дек. 12, 2021

For the past two decades, atomic gold nanoclusters (AuNCs, ultrasmall clusters of several to 100 atoms, having a total diameter <2 nm) have emerged as promising agents in diagnosis and treatment cancer. Owing their small size, significant quantization occurs conduction band, which leads emergent photonic properties disappearance plasmonic responses observed larger nanoparticles. example, AuNCs exhibit native luminescent properties, been well-explored literature. Using proteins, peptides, or other biomolecules structural scaffolds capping ligands, required for stabilization AuNCs, improves biocompatibility, while retaining distinct optical properties. This paved way use fluorescent bioimaging, later developed into multimodal imaging combined with computer tomography magnetic resonance examples. The development AuNC-based systems diagnostic applications cancer was then made possible by employing active passive tumor targeting strategies. Finally, potential therapeutic are extensive, used light-activated radiotherapy agents, well nanocarriers chemotherapeutic drugs, can be bound ligand directly via different mechanisms. In this review, we present an overview diverse biomedical terms imaging, therapy, combinations thereof, highlighting some additional relevant research.

Язык: Английский

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Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

Environment International, Год журнала: 2022, Номер 166, С. 107362 - 107362

Опубликована: Июнь 18, 2022

The adverse effects of plastic on adult animal and human health have been receiving increasing attention. However, its potential toxicity to fetuses has not fully elucidated. Herein, biodistribution polystyrene (PS) particles was determined after the maternal mice were orally given PS micro- and/or nano-particles with without surface modifications during gestational days 1 17. results showed that microplastics (MPs) nanoparticles (NPs) mainly emerged in alimentary tract, brain, uterus, placenta mice, only latter infiltrated into fetal thalamus. NPs carboxyl-modified induced differentially expressed genes enriched oxidative phosphorylation GABAergic synapse. Maternal administration gestation led anxiety-like behavior progenies their γ-aminobutyric acid (GABA) reduction prefrontal cortex amygdala at Week 8. N-Acetylcysteine (NAC), an antioxidant, alleviated particles-induced injury brain rescued progenies. Additionally, caused excessive ROS apoptosis neuronal cell lines, which prevented by glutathione supplementation. These suggested produced a negative effect inducing suppressing GABA synthesis brain. findings contribute estimating risk for health.

Язык: Английский

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Gold nanostructures: synthesis, properties, and neurological applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(7), С. 2601 - 2680

Опубликована: Янв. 1, 2022

Recent advances in nanotechnology are expected to increase our current understanding of neuroscience.

Язык: Английский

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Ultrasmall Coinage Metal Nanoclusters as Promising Theranostic Probes for Biomedical Applications

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(22), С. 11879 - 11898

Опубликована: Май 18, 2023

Ultrasmall coinage metal nanoclusters (NCs, <3 nm) have emerged as a novel class of theranostic probes due to their atomically precise size and engineered physicochemical properties. The rapid advances in the design applications NC-based are made possible by atomic-level engineering NCs. This Perspective article examines (i) how functions NCs for applications, (ii) probe is designed its properties affect performance, (iii) used diagnose treat various diseases. We first summarize tailored terms biocompatibility tumor targeting. focus our discussion on bioimaging-directed disease diagnosis, photoinduced therapy, nanomedicine, drug delivery, optical urinalysis. Lastly, an outlook challenges opportunities future development provided.

Язык: Английский

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Engineered Nanoerythrocytes Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia

Advanced Materials, Год журнала: 2022, Номер 34(27)

Опубликована: Апрель 28, 2022

Microglial polarization is one of the most promising therapeutic strategies for multiple central nervous system (CNS) disorders. However, safe, effective, and controllable microglial regulation still faces formidable challenges. Although some anti-inflammatory factors promote microglia polarization, their short half-life, high cost, unpredictable in vivo behavior, complex delivery operations, hamper clinical application. Here, inspired by natural microhemorrhage cleaning mechanism, an MG1 peptide RVG29 engineered nanoerythrocyte (NEMR) that can reprogram are developed from classical M1 toward alternative M2 inducing heme oxygenase-1 (HO-1), stimulating Notch1/Hes1/Stat3 signaling, further inhibiting NF-κB p65 translocation. Moreover, carbon monoxide (CO) bilirubin produced endogenous metabolism reinforces effect. In middle cerebral artery occlusion experimental autoimmune encephalomyelitis models, a satisfactory prognosis achieved, with precise inflammatory lesion sites, increased expression factors, reduced blood-brain barrier permeability, as well promotion neurogenesis functional recovery. Furthermore, NEMR be integrated agents, which facilitates drug to enhance effects. Hence, nanoerythrocytes, feasible, efficient, practical tool, provides new strategy rebalancing immune environment CNS

Язык: Английский

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Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Дек. 8, 2023

Nanomedicine-based anti-neuroinflammation strategy has become a promising dawn of Parkinson's disease (PD) treatment. However, there are significant gaps in our understanding the therapeutic mechanisms antioxidant nanomedicines concerning pathways traversing blood-brain barrier (BBB) and subsequent inflammation mitigation. Here, we report nanozyme-integrated metal-organic frameworks with excellent activity chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for treatment PD. These chiral nanozymes synthesized by embedding ultra-small platinum (Ptzymes) into L-chiral D-chiral imidazolate zeolite (Ptzyme@L-ZIF Ptzyme@D-ZIF). Compared to Ptzyme@L-ZIF, Ptzyme@D-ZIF shows higher accumulation brains male PD mouse models due longer plasma residence time more traverse BBB, including clathrin-mediated caveolae-mediated endocytosis. factors contribute superior efficacy reducing behavioral disorders pathological changes. Bioinformatics biochemical analyses suggest that inhibits neuroinflammation-induced apoptosis ferroptosis damaged neurons. The research uncovers biodistribution, metabolic variances, outcomes nanozymes-integrated ZIF platforms, providing possibilities devising anti-PD drugs.

Язык: Английский

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Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD). The intricate pathogenesis causes severe impairment neurons, which, turn, exacerbates Aβ aggregation facilitates AD progression. Herein, multifunctional melanin-like ion chelators neuroinflammation regulators (named PDA@K) were constructed for targeted treatment AD. In this platform, intrinsically bioactive material polydopamine nanoparticles (PDA) potent chelating ROS scavenging effects decorated the KLVFF peptide, endowing system capacity enhanced pathological blood–brain barrier (BBB) crossing lesion site accumulation via hitchhiking. vitro vivo experiment revealed that PDA@K had high affinity toward able to hitch a ride on achieve increased BBB crossing. engineered effectively mitigated aggregate alleviated neuroinflammation. modulated inflammatory microenvironment by promoted microglial polarization M2-like phenotype, which restored their functions neuron care plaque removal. After 3-week PDA@K, spatial learning memory deficit as well neurologic changes FAD 4T transgenic mice largely rescued. Transcriptomics analysis further therapeutic mechanism PDA@K. Our study provided an appealing paradigm directly utilizing intrinsic properties nanomaterials therapeutics instead just using them nanocarriers, widen application therapy.

Язык: Английский

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Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model

The Journal of Headache and Pain, Год журнала: 2024, Номер 25(1)

Опубликована: Янв. 5, 2024

Abstract Background Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associated with development chronic migraine (CM). TREM1 receptors amplify inflammatory response. However, their relationship CM unclear. Thus, this study endeavoured elucidate exact role in CM. Methods Nitroglycerin (NTG) was repeatedly administered intraperitoneally establish model. Mechanical and thermal sensitivities were assessed using von Frey filaments hot plate assays. Using Western blotting, TREM1, NF-κB pathway, NLRP3 inflammasome components, proinflammatory cytokines all detected. Immunofluorescence used examine cellular distribution NLRP3, number immunoreactivity, morphological changes. We examined effects antagonists (LR12) inhibitors (PDTC) on pain behaviour, as well production c-fos CGRP. Additionally, we investigated whether LR12 PDTC affect microglia inflammasome. synthesized siRNA TREM1-overexpressing plasmids transfect BV2 cells treated LPS normal PDTC. The quantified blotting. Results Following NTG administration, expression significantly upregulated exclusively localized TNC, co-localized NLRP3. Furthermore, classical pathway observed. Pre-treatment effectively attenuated mechanical hypersensitivity, suppressed CGRP, inhibited activity mice. inhibition mitigated NTG-induced activation, production. In vitro, knockdown resulted following lipopolysaccharide (LPS) treatment reduced components cytokines. After overexpression, activated, upregulated, reversed phenomenon. Conclusions Our findings suggest that regulates via thereby contributing sensitization implicating its involvement pathogenesis.

Язык: Английский

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