Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(8), С. 1863 - 1876
Опубликована: Фев. 21, 2024
Abstract
Ru(II)‐catalyzed
and
solvent‐switched
[3+2]‐spiroannulation
[4+n]
(n=1,
2,
3)
annulations
of
2‐aryl
quinazolinone
or
2‐aryl‐2,3‐dihydrophthalazine‐1,4‐diones
with
ynones
alkynyl
alcohol
1,3‐diynes
under
mild
reaction
conditions
have
been
analyzed.
These
reactions
take
place
in
the
presence
appropriate
solvent
features
a
redox‐neutral
pathway.
Ynone
serves
as
an
‘atypical
one‐carbon
unit’
[4+1]
annulation
generates
tetrasubstituted
carbon
center
bearing
diverse
heterocycles
through
[3+2]
strategies.
Post
transformations
synthesized
spiro‐products
augments
potential
developed
methodology.
Green Chemistry,
Год журнала:
2024,
Номер
26(7), С. 4199 - 4208
Опубликована: Янв. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
364(3), С. 512 - 517
Опубликована: Ноя. 30, 2021
Abstract
The
rhodium(III)‐catalyzed
C−H
bond
activation
and
vinylene
transfer
of
enaminones
with
carbonate
have
been
proposed
for
the
synthesis
substituted
1‐hydroxy‐2‐naphthaldehydes
in
49–84%
yields.
Several
preliminary
mechanistic
studies
hydroxyl‐directed
derivatization
reactions
were
also
performed.
This
method
offers
an
alternative
approach
1‐hydroxy‐2‐naphthaldehydes.
magnified
image
Organic Letters,
Год журнала:
2021,
Номер
23(21), С. 8527 - 8532
Опубликована: Окт. 20, 2021
Here
we
report
a
novel
Rh-catalyzed
C−H/C−H
alkenylation
of
N-arylmethanimines
with
vinylene
carbonate
acting
as
unit.
Forty
examples
C3,C4-nonsubstituted
quinolines
were
achieved
from
commercially
available
starting
materials.
This
identified
process
features
an
exceedingly
simple
system,
lower
loading
catalyst,
and
the
capacity
for
postfunctionalization
bioactive
molecules.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(32), С. 6293 - 6313
Опубликована: Янв. 1, 2022
As
one
of
the
most
important
structural
units
in
pharmaceuticals
and
medicinal
chemistry,
quinazolinone
its
derivatives
exhibit
a
wide
range
biological
pharmacological
activities,
including
anti-inflammatory,
antitubercular,
antiviral,
anticancer
etc.
In
particular,
2,3-fused
quinazolinones
have
attracted
much
attention
because
rings
fused
to
2,3-positions
improve
their
rigidity
planarity.
Their
synthetic
strategies
made
great
advances
recent
years.
Therefore,
this
review
focuses
on
novel
for
synthesis
from
2017
2022,
such
as
difunctionalization
alkenes,
ring-opening
easily
available
small
rings,
dehydrogenative
cross-coupling
reactions,
transition-metal
catalyzed
cyclizations,
cycloadditions,
other
cascade
reactions.
Organic Letters,
Год журнала:
2021,
Номер
23(14), С. 5518 - 5522
Опубликована: Июль 6, 2021
The
Rh(III)-catalyzed
C–H
functionalization
and
subsequent
intramolecular
cyclization
between
azobenzenes
vinylene
carbonate
is
described
herein.
Depending
on
the
electronic
property
of
azobenzenes,
this
transformation
results
in
formation
(2H)-indazoles
or
dihydrocinnolin-4-ones
through
generation
ortho-alkylated
azo-intermediates
followed
by
decarboxylation.
Surprisingly,
acts
as
an
acetaldehyde
acetyl
surrogate
to
enable
[4
+
1]
2]
annulation
reaction.
This
characterized
its
mild
reaction
conditions,
simplicity,
excellent
functional
group
compatibility.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(24), С. 18204 - 18210
Опубликована: Ноя. 25, 2021
Manganese-catalyzed
C-H
bond
functionalization
of
aryl
amidines
for
the
synthesis
1-aminoisoquinolines
in
presence
vinylene
carbonate
has
been
developed.
The
reaction
features
a
broad
substrate
scope
and
proceeds
under
mild
conditions
with
only
anion
as
byproduct.
Organic Letters,
Год журнала:
2022,
Номер
24(14), С. 2613 - 2618
Опубликована: Апрель 4, 2022
A
rhodium-catalyzed
cyclization
of
azobenzenes
and
vinylene
carbonate
via
C-H
bond
activation
to
construct
indazolo[2,3-a]quinolines
has
been
developed.
This
protocol
offers
an
efficient
method
for
synthesis
the
titled
products
in
good
yields
with
broad
functional
group
tolerance.
In
this
reaction,
three
C-C
bonds
C-N
are
formed
one
pot,
(VC)
acts
as
C1
C2
synthons
well
"vinylene
transfer"
agent
acylation
reagent
construction
target-fused
heterocycles.
Moreover,
exhibit
favorable
fluorescence
properties,
which
indicate
their
potential
application
fluorescent
materials
biosensors.
Chemical Communications,
Год журнала:
2022,
Номер
58(28), С. 4476 - 4479
Опубликована: Янв. 1, 2022
A
ruthenium-catalyzed
oxidative
coupling
of
vinylene
carbonate
with
isoxazoles
has
been
developed
to
achieve
the
direct
C-H
formylmethylation
a
diverse
array
arylisoxazoles
utilizing
isoxazole
ring
as
directing
group.
simple
manipulation
established
reaction
conditions
leads
formation
fused-anthranils.
Importantly,
functions
both
formylmethyl
cation
equivalent
through
decarboxylation
process
and
an
acetylene
equivalent.
Control
experiments
were
conducted
elucidate
plausible
mechanism.
This
methodology
is
expected
provide
facile
expeditious
approach
for
synthesis
