Synthesis of phosphonate-containing compounds

Tetrahedron, Год журнала: 2023, Номер 149, С. 133708 - 133708

Опубликована: Окт. 27, 2023

Язык: Английский

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Aza-Wittig reaction of (β-diazo-α,α-difluoroethyl)phosphonates with aldehydes for the synthesis of difluoromethylphosphonate-containing arylidene hydrazones

Journal of Fluorine Chemistry, Год журнала: 2023, Номер 273, С. 110226 - 110226

Опубликована: Ноя. 29, 2023

Язык: Английский

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Catalyst-free gem-chlorosulfurization of difluoromethyl-substituted diazo compounds with disulfide and PhICl₂

Organic & Biomolecular Chemistry, Год журнала: 2021, Номер 19(37), С. 8030 - 8034

Опубликована: Янв. 1, 2021

A series of gem -chlorosulfurization products bearing difluoromethyl substituents were synthesized from TsCF 2 CHN , disulfides and PhICl under mild conditions, which could be efficiently converted to multi-component by a facile operation.

Язык: Английский

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Cu‐Catalyzed Reaction of Trifluoromethylated β‐Keto Diazos and Nitriles Proceeding via H₂O Addition to Nitrile Ylides

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(16), С. 3443 - 3449

Опубликована: Май 22, 2024

Abstract A Cu‐catalyzed multi‐component reaction of trifluoromethylated β‐amino ketones and nitriles using tert ‐butyl nitrite as a diazotization reagent has been developed. Under the optimized conditions, N ‐trifluoroalkyl amides were obtained with yields up to 87%. Control experiments computational studies reveal that proceeds through generation diazo, in situ formation nitrile ylide, water addition final enol tautomerism. This approach features mild wide substrate tolerance, scale‐up applicability, which provides an efficient practical strategy for amide synthesis.

Язык: Английский

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Regioselective synthesis of 3H-Pyrazoles bearing difluoromethyl phosphonate group

Journal of Fluorine Chemistry, Год журнала: 2023, Номер 273, С. 110218 - 110218

Опубликована: Ноя. 21, 2023

Язык: Английский

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