Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 5, 2024
Abstract
Diazophosphonates
function
as
indispensable
synthetic
intermediates
within
the
domain
of
organic
chemistry,
serving
precursors
for
a
diverse
range
molecules,
with
potential
applications
bioactive
compounds.
α-Diazomethylphosphonates
showcase
expansive
reactivity
and
elevated
levels
enantioselectivity
in
asymmetric
transformations,
especially
conjunction
suitable
catalyst
systems.
This
review
compiles
latest
advancements
diazophosphonate
chemistry
from
2016
to
2024,
highlighting
their
transformative
synthesis.
Diazophosphonates,
regarded
revolutionary
compounds,
exhibit
unique
attributes
carbene
precursors,
driving
chemical
reactions
such
[3+2]
cycloaddition,
[3+3]
substitution
reactions.
Their
adaptability
functional
group
conversions
underscores
pivotal
role
various
methodologies.
The
highlights
growing
interest
among
chemists,
fostering
novel
strategies
expanding
application
horizons.
multifaceted
utility
diazophosphonates
reagents,
intermediates,
catalysts
significance
modern
pharmaceutical
applications,
prompting
further
exploration
into
this
dynamic
field.
1
Introduction
2
Cycloaddition
Reactions
3
Asymmetric
4
5
Substitution
6
Carbene
Precursors
7
Chemistry
Fluorinated
Compounds
8
Other
9
Future
Directions
10
Conclusion
Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(37), P. 8030 - 8034
Published: Jan. 1, 2021
A
series
of
gem
-chlorosulfurization
products
bearing
difluoromethyl
substituents
were
synthesized
from
TsCF
2
CHN
,
disulfides
and
PhICl
under
mild
conditions,
which
could
be
efficiently
converted
to
multi-component
by
a
facile
operation.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(16), P. 3443 - 3449
Published: May 22, 2024
Abstract
A
Cu‐catalyzed
multi‐component
reaction
of
trifluoromethylated
β‐amino
ketones
and
nitriles
using
tert
‐butyl
nitrite
as
a
diazotization
reagent
has
been
developed.
Under
the
optimized
conditions,
N
‐trifluoroalkyl
amides
were
obtained
with
yields
up
to
87%.
Control
experiments
computational
studies
reveal
that
proceeds
through
generation
diazo,
in
situ
formation
nitrile
ylide,
water
addition
final
enol
tautomerism.
This
approach
features
mild
wide
substrate
tolerance,
scale‐up
applicability,
which
provides
an
efficient
practical
strategy
for
amide
synthesis.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 5, 2024
Abstract
Diazophosphonates
function
as
indispensable
synthetic
intermediates
within
the
domain
of
organic
chemistry,
serving
precursors
for
a
diverse
range
molecules,
with
potential
applications
bioactive
compounds.
α-Diazomethylphosphonates
showcase
expansive
reactivity
and
elevated
levels
enantioselectivity
in
asymmetric
transformations,
especially
conjunction
suitable
catalyst
systems.
This
review
compiles
latest
advancements
diazophosphonate
chemistry
from
2016
to
2024,
highlighting
their
transformative
synthesis.
Diazophosphonates,
regarded
revolutionary
compounds,
exhibit
unique
attributes
carbene
precursors,
driving
chemical
reactions
such
[3+2]
cycloaddition,
[3+3]
substitution
reactions.
Their
adaptability
functional
group
conversions
underscores
pivotal
role
various
methodologies.
The
highlights
growing
interest
among
chemists,
fostering
novel
strategies
expanding
application
horizons.
multifaceted
utility
diazophosphonates
reagents,
intermediates,
catalysts
significance
modern
pharmaceutical
applications,
prompting
further
exploration
into
this
dynamic
field.
1
Introduction
2
Cycloaddition
Reactions
3
Asymmetric
4
5
Substitution
6
Carbene
Precursors
7
Chemistry
Fluorinated
Compounds
8
Other
9
Future
Directions
10
Conclusion
