The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(22), С. 15582 - 15597
Опубликована: Ноя. 1, 2022
A
general
visible-light-induced
photocatalyst-/additive-free
strategy
was
developed
for
the
construction
of
various
nitrogen-heterocycles
(42
examples,
up
to
97%
yield)
such
as
γ-lactams,
δ-lactams,
pyrrolidines,
indolones,
quinolinones,
and
fused
polycyclic
structures
at
room
temperature.
The
prominent
features
this
protocol
are
mild
environmentally
friendly
conditions,
broad
substrate
scope,
good
functional
group
tolerance.
Importantly,
reaction
can
be
performed
under
natural
sunlight,
most
sustainable
energy
source
imaginable.
Furthermore,
provides
straightforward
access
a
range
derivatives
through
subsequent
elaboration
xanthate
group.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(10), С. 1750 - 1756
Опубликована: Апрель 1, 2022
Abstract
A
mild
and
safe
photochemical
methodology
has
been
developed
to
access
difluoroamidosulfonylated
dioxodibenzothiazepines
via
three‐component
radical
bicyclization
cascades.
This
photocatalyst‐free
transformation
avoids
cumbersome
photocatalyst
removal
procedure
potential
toxicity.
Mechanistic
experiments
reveal
the
generation
of
an
electron
donor‐acceptor
(EDA)
complex
in
reaction
process.
Moreover,
synthetic
value
protocol
is
further
demonstrated
by
gram‐scale
reaction,
conversion
product
total
synthesis
antidepressant
drug.
magnified
image
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(22), С. 10744 - 10750
Опубликована: Янв. 1, 2023
A
photocatalyst-free
visible-light-promoted
tandem
intramolecular
cyclization/heteroarylation
between
bromodifluoroacetamides
and
quinoxalin-2(1
H
)-ones
or
coumarins
was
developed.
The
process
could
generate
a
broad
range
of
α
,
-difluoro-γ-lactams.
Asian Journal of Organic Chemistry,
Год журнала:
2021,
Номер
10(12), С. 3390 - 3395
Опубликована: Окт. 9, 2021
Abstract
A
mild,
external
photocatalyst‐
and
additive‐free
protocol
for
photo‐induced
alkylation/cyclization
of
unactivated
alkenes
with
halides
has
been
developed.
This
strategy
showed
excellent
regioselectivity
simple
operation
to
synthesize
alkyl‐substituted
quinazolinones
a
broad
substrate
scope.
More
importantly,
chlorinated
alkanes
were
also
compatible
this
transformation.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(22), С. 15582 - 15597
Опубликована: Ноя. 1, 2022
A
general
visible-light-induced
photocatalyst-/additive-free
strategy
was
developed
for
the
construction
of
various
nitrogen-heterocycles
(42
examples,
up
to
97%
yield)
such
as
γ-lactams,
δ-lactams,
pyrrolidines,
indolones,
quinolinones,
and
fused
polycyclic
structures
at
room
temperature.
The
prominent
features
this
protocol
are
mild
environmentally
friendly
conditions,
broad
substrate
scope,
good
functional
group
tolerance.
Importantly,
reaction
can
be
performed
under
natural
sunlight,
most
sustainable
energy
source
imaginable.
Furthermore,
provides
straightforward
access
a
range
derivatives
through
subsequent
elaboration
xanthate
group.
