Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 21, 2022
A
transition-metal-free
method
for
the
construction
of
3-substituted
or
3,4-disubstituted
quinolines
from
readily
available
N,N-dimethyl
enaminones
and
o-aminobenzyl
alcohols
is
reported.
The
direct
oxidative
cyclocondensation
reaction
tolerates
broad
functional
groups,
allowing
efficient
synthesis
various
in
moderate
to
excellent
yields.
involves
a
C
(sp3)-O
bond
cleavage
C=N
bind
C=C
formation
during
cyclization
process,
mechanism
was
proposed.
Chemical Communications,
Год журнала:
2023,
Номер
59(27), С. 4036 - 4039
Опубликована: Янв. 1, 2023
The
synthesis
of
N-naphthyl
pyrazoles
has
been
realized
by
the
direct
three-component
reactions
enaminones,
aryl
hydrazine
hydrochlorides
and
internal
alkynes
via
Rh(III)
catalysis.
synthetic
employing
simple
substrates
lead
to
simultaneous
construction
dual
cyclic
moieties,
including
a
pyrazole
ring
phenyl
ring,
sequential
formation
two
C-N
three
C-C
bonds.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2363 - 2369
Опубликована: Март 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(14), С. 3906 - 3912
Опубликована: Янв. 1, 2024
A
chemodivergent
and
skeleton-controllable
annulation
reactions
of
readily
available
o
-HPEs
aryldiazonium
salts
was
described
for
the
synthesis
highly
functionalized
pyridazine-fused
chromones
with
high
antiviral
activity
higher
safety.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(19), С. 13195 - 13203
Опубликована: Сен. 15, 2022
Visible
light
photocatalytic
reactions
of
NH2-enaminones
and
ammonium
thiocyanate
for
chemoselective
α-C-H
thiocyanation
have
been
realized
the
first
time,
providing
a
sustainable
route
synthesis
thiocyanated
NH2-enaminones.
In
addition,
enaminone
products
can
be
flexibly
transformed
into
2-aminothiazoles
2-thiazolinones
via
simple
operation.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(28)
Опубликована: Фев. 24, 2023
Using
benzylamines
as
the
C4
source
of
1,4-dihydropyridines
(1,4-DHPs),
a
Cu-catalyzed
oxidative
[1+2+1+2]
cascade
cyclization
for
synthesis
1,4-DHPs
was
firstly
developed.
A
broad
range
easily
available
N,N-dimethyl
enaminones
and
are
employed
smoothly
to
provide
diverse
with
high
efficiency.
This
method
is
performed
by
one-pot
C(sp3
)-H
bond
functionalization/C(sp3
)-N
cleavage/cyclization
strategy
form
simultaneously
two
)-C(sp2
)
bonds,
C(sp2
1,4-DHP
ring.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(9), С. 1602 - 1606
Опубликована: Март 19, 2022
Abstract
The
C(
sp
2
)−H
phosphorothiolation
involving
cyclization
process
through
a
transition‐metal‐free
strategy
is
reported.
It
provides
an
attractive
approach
for
the
construction
valuable
S
‐3‐chromon
phosphorothioates
from
o
‐hydroxyarylenaminones
and
P(O)SH
compounds
in
presence
of
1.0
equiv.
iodine
at
60
°C.
This
novel
protocol
shows
readily
available
chemicals,
broad
substrate
scope,
mild
reaction
conditions.
magnified
image
Chemical Communications,
Год журнала:
2021,
Номер
57(72), С. 9112 - 9115
Опубликована: Янв. 1, 2021
The
C–N
bond
cyanation
of
tertiary
enaminones
has
been
realized
for
the
stereoselective
synthesis
both
(
E
)-
and
Z
)-β-cyano
enones
under
mild
metal-free
conditions,
providing
highly
practical
approaches
β-cyano
enones.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(24), С. 4440 - 4446
Опубликована: Дек. 2, 2022
Abstract
A
silver‐catalyzed
protocol
for
the
synthesis
of
3‐(1
H
‐isochromen)‐chromones
is
described.
The
method
involves
an
initial
6‐endo‐dig
cyclization
o
‐alkynylbenzaldehydes
and
domino
C−H
alkylation
chromone
annulation
‐hydroxyarylenaminones,
which
enables
installation
1
‐isochromen
in
a
single
structure.
This
synthetic
strategy
advantageous
excellent
regioselectivity,
step
economy,
concise
one‐pot
methodology,
gram‐scale
synthesis,
as
well
high
bond‐forming
efficiency.
magnified
image
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(17), С. 4298 - 4304
Опубликована: Янв. 1, 2023
This
method
involves
a
cascade
reaction
utilizing
1
and
enamines
2
as
substrates,
which
occurred
by
refluxing
mixture
of
the
starting
materials
in
toluene
with
catalyst
Fe(OTf)
3
.
