Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(12), P. 2596 - 2602
Published: Jan. 1, 2023
A
metal-free
regioselective
oxidative
annulation
reaction
of
readily
available
2,4-pentanediones
with
primary
amines
has
been
described.
This
protocol
provides
a
divergent
strategy
for
the
incorporation
various
radical
donors
into
5-alkylidene
3-pyrrolin-2-one
skeletons,
producing
variety
thiionized-,
selenolized-,
and
alkylated
derivatives.
Moreover,
diverse
synthetic
transformations
products
were
also
investigated.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(27), P. 4036 - 4039
Published: Jan. 1, 2023
The
synthesis
of
N-naphthyl
pyrazoles
has
been
realized
by
the
direct
three-component
reactions
enaminones,
aryl
hydrazine
hydrochlorides
and
internal
alkynes
via
Rh(III)
catalysis.
synthetic
employing
simple
substrates
lead
to
simultaneous
construction
dual
cyclic
moieties,
including
a
pyrazole
ring
phenyl
ring,
sequential
formation
two
C-N
three
C-C
bonds.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2363 - 2369
Published: March 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3906 - 3912
Published: Jan. 1, 2024
A
chemodivergent
and
skeleton-controllable
annulation
reactions
of
readily
available
o
-HPEs
aryldiazonium
salts
was
described
for
the
synthesis
highly
functionalized
pyridazine-fused
chromones
with
high
antiviral
activity
higher
safety.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 13195 - 13203
Published: Sept. 15, 2022
Visible
light
photocatalytic
reactions
of
NH2-enaminones
and
ammonium
thiocyanate
for
chemoselective
α-C-H
thiocyanation
have
been
realized
the
first
time,
providing
a
sustainable
route
synthesis
thiocyanated
NH2-enaminones.
In
addition,
enaminone
products
can
be
flexibly
transformed
into
2-aminothiazoles
2-thiazolinones
via
simple
operation.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(28)
Published: Feb. 24, 2023
Using
benzylamines
as
the
C4
source
of
1,4-dihydropyridines
(1,4-DHPs),
a
Cu-catalyzed
oxidative
[1+2+1+2]
cascade
cyclization
for
synthesis
1,4-DHPs
was
firstly
developed.
A
broad
range
easily
available
N,N-dimethyl
enaminones
and
are
employed
smoothly
to
provide
diverse
with
high
efficiency.
This
method
is
performed
by
one-pot
C(sp3
)-H
bond
functionalization/C(sp3
)-N
cleavage/cyclization
strategy
form
simultaneously
two
)-C(sp2
)
bonds,
C(sp2
1,4-DHP
ring.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(9), P. 1602 - 1606
Published: March 19, 2022
Abstract
The
C(
sp
2
)−H
phosphorothiolation
involving
cyclization
process
through
a
transition‐metal‐free
strategy
is
reported.
It
provides
an
attractive
approach
for
the
construction
valuable
S
‐3‐chromon
phosphorothioates
from
o
‐hydroxyarylenaminones
and
P(O)SH
compounds
in
presence
of
1.0
equiv.
iodine
at
60
°C.
This
novel
protocol
shows
readily
available
chemicals,
broad
substrate
scope,
mild
reaction
conditions.
magnified
image
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
57(72), P. 9112 - 9115
Published: Jan. 1, 2021
The
C–N
bond
cyanation
of
tertiary
enaminones
has
been
realized
for
the
stereoselective
synthesis
both
(
E
)-
and
Z
)-β-cyano
enones
under
mild
metal-free
conditions,
providing
highly
practical
approaches
β-cyano
enones.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(24), P. 4440 - 4446
Published: Dec. 2, 2022
Abstract
A
silver‐catalyzed
protocol
for
the
synthesis
of
3‐(1
H
‐isochromen)‐chromones
is
described.
The
method
involves
an
initial
6‐endo‐dig
cyclization
o
‐alkynylbenzaldehydes
and
domino
C−H
alkylation
chromone
annulation
‐hydroxyarylenaminones,
which
enables
installation
1
‐isochromen
in
a
single
structure.
This
synthetic
strategy
advantageous
excellent
regioselectivity,
step
economy,
concise
one‐pot
methodology,
gram‐scale
synthesis,
as
well
high
bond‐forming
efficiency.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(17), P. 4298 - 4304
Published: Jan. 1, 2023
This
method
involves
a
cascade
reaction
utilizing
1
and
enamines
2
as
substrates,
which
occurred
by
refluxing
mixture
of
the
starting
materials
in
toluene
with
catalyst
Fe(OTf)
3
.
