The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2433 - 2442
Опубликована: Фев. 8, 2023
A
simple
and
concise
method
for
the
synthesis
of
cinnolines
has
been
developed
by
reactions
readily
available
enaminones
aryl
diazonium
tetrafluoroboronates.
The
run
efficiently
to
provide
with
broad
diversity
in
substructure
heating
dimethyl
sulfoxide
without
using
any
catalyst
or
additive.
In
addition,
primary
investigation
anti-inflammatory
activity
these
products
leads
observation
p-chlorobenzoyl
(3f)
p-nitrobenzoyl
(3j)
as
attractive
compounds
vitro.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(6), С. 3941 - 3953
Опубликована: Фев. 29, 2024
An
efficient
synthetic
method
for
constructing
2,3-
and
2,4-disubstituted
pyrimidio[1,2-b]indazole
skeletons
through
I2-DMSO-mediated
substrate-controlled
regioselective
[4
+
2]
cyclization
is
reported.
The
reaction
conditions
are
mild,
its
operation
simple,
the
substrate
scope
wide.
More
than
60
derivatives
have
been
synthesized,
providing
a
new
methodology
related
molecules
potentially
enriching
bioactive-molecule
libraries.
Organic Letters,
Год журнала:
2022,
Номер
24(39), С. 7118 - 7122
Опубликована: Сен. 25, 2022
Herein,
a
photoinitiated
radical
relay
reaction
of
quinoxalin-2(1H)-ones,
with
acyloxy
nitroso
compounds
as
source
radicals,
is
described.
Although
the
C-H
functionalization
quinoxalin-2(1H)-ones
has
been
investigated,
its
difunctionalization,
simultaneous
construction
C-C
and
N-N
bonds
directly
via
reaction,
rarely
reported.
Moreover,
obtained
products
underwent
sequential
reactions
to
access
C7-NO2
under
mild
conditions.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(21), С. 14957 - 14964
Опубликована: Окт. 19, 2022
The
Dess-Martin
periodinane
(DMP)
reagent-mediated
reactions
of
tertiary
enaminones
with
potassium
thiocyanate
for
the
synthesis
thiazole-5-carbaldehydes
are
developed.
product
formation
involves
cascade
hydroxyl
thiocyanation
C═C
double
bond,
intramolecular
hydroamination
C≡N
and
thiazole
annulation
by
condensation
on
ketone
carbonyl
site,
representing
novel
reaction
pathways
in
between
salt.
DMP
plays
dual
roles
mediating
free
radical
inducing
unconventional
selective
thiazole-5-carbaldehyde
masking
situ
generated
formyl
group
during
process.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(20), С. 3539 - 3543
Опубликована: Авг. 26, 2022
Abstract
A
photoinduced
multicomponent
reaction
of
arylamines,
enaminones
and
difluorobromoacetates
for
the
synthesis
2,3‐difunctionalized
quinolines
is
reported.
This
strategy
features
broad
functional
groups
tolerance
wide
substrate
scopes
that
enables
further
synthetic
applications
obtained
products.
Mechanistic
studies
reveal
intermolecular
[3+3]
cyclization
between
in‐situ
generated
1,3‐vinylimine
ions
arylamines
key
step
in
this
transformation.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2433 - 2442
Опубликована: Фев. 8, 2023
A
simple
and
concise
method
for
the
synthesis
of
cinnolines
has
been
developed
by
reactions
readily
available
enaminones
aryl
diazonium
tetrafluoroboronates.
The
run
efficiently
to
provide
with
broad
diversity
in
substructure
heating
dimethyl
sulfoxide
without
using
any
catalyst
or
additive.
In
addition,
primary
investigation
anti-inflammatory
activity
these
products
leads
observation
p-chlorobenzoyl
(3f)
p-nitrobenzoyl
(3j)
as
attractive
compounds
vitro.
