Asian Journal of Organic Chemistry,
Год журнала:
2022,
Номер
12(1)
Опубликована: Ноя. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(12), С. 8248 - 8255
Опубликована: Май 26, 2022
Ultrasound
has
been
successfully
employed
to
promote
the
thiocyanation
of
C═C
bond
in
enaminones
for
synthesis
α-thiocyanoketones
and
2-aminothiazoles.
The
reactions
with
ammonium
thiocyanate
provide
ultrasound
irradiation
at
room
temperature.
More
interestingly,
simply
further
heating
vessel
after
ultrasonic
leads
selective
2-aminothiazoles
an
unconventional
4-aryl
substructure.
Organic Letters,
Год журнала:
2022,
Номер
24(37), С. 6822 - 6827
Опубликована: Сен. 9, 2022
A
straightforward
strategy
for
the
metal-free
construction
of
trifluoromethyl-containing
pyrazole
derivatives
has
been
achieved
from
readily
available
α-halo
hydrazones
and
CF3-imidoyl
sulfoxonium
ylides.
The
cascade
transformation
proceeds
through
formal
[4+1]
cycloaddition
followed
by
an
unexpected
dual
double
bond
isomerization.
protocol
features
mild
conditions,
easy
operation,
excellent
substrate
compatibility,
good
regioselectivity.
synthetic
utility
is
demonstrated
scale-up
reaction
further
elaboration
obtained
products.
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Abstract
Selectfluor,
[1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane
bis(tetrafluoroborate)],
is
a
highly
valuable
reagent
in
contemporary
chemistry,
serving
not
only
as
an
electrophilic
fluorinating
agent
but
also
effective
catalyst
the
synthesis
of
various
pharmaceutically
relevant
heterocycles.
This
review
article
seeks
to
present
comprehensive
overview
significant
heterocyclic
ring
formations
facilitated
by
selectfluor.
Both
metal‐free
and
metal‐catalyzed
recent
advancement
on
selectfluor
mediated
cyclisation
processes
are
discussed
this
mainly
over
last
eight
years
(2017‐April
2024).
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(19), С. 13138 - 13153
Опубликована: Сен. 27, 2022
Electrochemical
synthesis
of
polysubstituted
sulfonated
pyrazoles
from
enaminones
and
sulfonyl
hydrazides
was
established
under
metal-free,
exogenous-oxidant-free,
mild
conditions.
By
judicious
choice
different
electrochemical
reaction
conditions,
NH2-functionalized
or
N,N-disubstituted
can
react
with
aryl/alkyl
to
afford
tetra-
trisubstituted
in
moderate
good
yields,
respectively.
The
gram-scale
transformation
demonstrated
the
efficiency
practicability
this
synthetic
strategy.
In
addition,
NH-pyrazole
be
obtained
via
dissociation
N-tosyl
group.
Mechanistic
studies
reveal
that
cascade
proceeded
sequence
intermolecular
condensation,
radical-radical
cross
coupling
sulfonylation,
pyrazole
annulation.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(21), С. 14957 - 14964
Опубликована: Окт. 19, 2022
The
Dess-Martin
periodinane
(DMP)
reagent-mediated
reactions
of
tertiary
enaminones
with
potassium
thiocyanate
for
the
synthesis
thiazole-5-carbaldehydes
are
developed.
product
formation
involves
cascade
hydroxyl
thiocyanation
C═C
double
bond,
intramolecular
hydroamination
C≡N
and
thiazole
annulation
by
condensation
on
ketone
carbonyl
site,
representing
novel
reaction
pathways
in
between
salt.
DMP
plays
dual
roles
mediating
free
radical
inducing
unconventional
selective
thiazole-5-carbaldehyde
masking
situ
generated
formyl
group
during
process.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2190 - 2206
Опубликована: Фев. 1, 2023
A
copper-promoted
aerobic
oxidative
[3+2]
cycloaddition
reaction
for
the
synthesis
of
various
substituted
pyrazoles
from
N,N-disubstituted
hydrazines
with
alkynoates
in
presence
bases
is
developed.
This
work
involves
a
direct
C(sp3)-H
functionalization
and
formation
new
C-C/C-N
bonds.
In
this
strategy,
inexpensive
easily
available
Cu2O
serves
as
promoter
air
acts
green
oxidant.
The
exhibits
advantages
high
atom
step
economy,
regioselectivity,
easy
operation.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 216 - 223
Опубликована: Дек. 18, 2023
The
C–N
bond
transamidation
of
primary
amides
with
N,N-dimethyl
enaminones
has
been
efficiently
realized
by
heating
in
the
presence
trifluoromethanesulfonic
acid
(TfOH).
method
enables
practical
synthesis
valuable
enamides
without
use
any
metal
reagent.
In
addition,
this
protocol
can
also
be
expanded
to
reactions
sulfonamides,
and
late-stage
functionalization
on
sulfonamide
drugs
such
as
Celecoxib
Valdecoxib
verified.
Moreover,
participation
water
assisting
process
identified
isotope
labeling
experiments
using
D2O,
disclosing
a
new
possibility
designing
catalytic
tactic
other
reactions.
Synthesis,
Год журнала:
2024,
Номер
56(16), С. 2565 - 2571
Опубликована: Апрель 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
