The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15733 - 15738
Опубликована: Окт. 16, 2024
Remarkable
progress
has
been
made
in
the
radical
cascade
cyclization
of
heteroaryl-
or
aryl-tethered
alkenes
to
construct
benzene-fused
frameworks
via
cracking
aryl
C–H
bonds.
In
contrast,
linear
dienes
through
vinyl
bonds
nonbenzene-fused
ring
with
endocyclic
double
significantly
lagged
behind,
and
major
advances
have
largely
restricted
generation
5-membered
heterocycles,
such
as
pyrrolinones.
Herein,
we
report
silver-mediated
regioselective
sulfonylation-cyclization
sodium
sulfinates
form
sulfonylated
6-
7-membered
cyclic
enamines.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
β-Enaminone
transformation
strategies
are
widely
employed
in
the
synthesis
of
numerous
biologically
active
drugs
and
natural
products,
highlighting
their
significance
medicinal
chemistry.
In
this
work,
a
tunable
reaction
of
metal
acyl
nitrene
with
ylides
is
reported
for
the
divergent
synthesis
enamides
and
α,α-dicarbonyl
phosphorus
ylides.
The
featured
mild
conditions,
good
efficiency,
broad
generality.
particular,
resulting
could
be
structurally
elaborated
into
potential
useful
scaffolds.
Mechanism
investigation
suggests
that
formation
was
ascribed
to
nucleophilic
substitution
ferric
sulfur
It
believed
represents
an
initial
example
preparing
from
iron-catalyzed
transfer.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
A
facile
method
with
simple
starting
materials,
including
enaminones,
α-diazo
esters,
and
nitriles,
has
been
developed
for
the
direct
synthesis
of
N,N-diacyl
glycine
esters
via
visible
light
photocatalysis.
The
reaction
involves
a
novel
carbon-carbon
bond
cleavage
in
leading
to
products
high
tolerance
variability
substructures
among
all
three
components.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5784 - 5790
Опубликована: Янв. 1, 2024
The
radical
cascade
cyclization
of
vinyl-tethered
alkenes
has
become
a
promising
tool
for
rapidly
assembling
nonbenzene-fused
cyclic
skeletons
via
the
cracking
alkenyl
C–H
bonds,
but
this
approach
been
limited
to
generate
five-membered
rings.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10538 - 10550
Опубликована: Июль 12, 2024
C3-functionalized
dihydroquinolinones
represent
a
class
of
important
biologically
active
compounds.
Although
methods
for
synthesizing
C2/4-functionalized
have
been
extensively
reported,
research
on
the
synthesis
dihydroquinolinone
is
extremely
rare.
Herein,
we
report
first
time
method
C3-alkenylated
via
iron(III)-catalyzed
amine-release
triple
condensation
enaminones.
These
reactions
exhibit
broad
substrate
scope
and
offer
operationally
simple,
low-cost
catalyzed
procedures
in
single
step.
Subsequent
intramolecular
intermolecular
additions
to
alkene
moiety
provide
diverse
derivatives.
