The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 425 - 432
Опубликована: Дек. 12, 2023
Spirobenzofuran
scaffolds,
because
of
their
three-dimensional
structure,
are
incorporated
into
several
valuable
natural
products
and
drug
candidate
molecules.
Herein,
with
the
assistance
electrosynthesis,
we
introduce
a
novel
electrochemical
approach
for
achieving
spirobenzofurans
in
user-friendly
operationally
simple
undivided
cell
setup
under
constant
current.
This
metal-catalyst-free
procedure
afforded
spiro[benzofuran-2,2′-furan]-3-ones
high
diastereoselectivity.
Compatibility
gram-scale
synthesis
along
convenient
accessibility
reaction
instruments
starting
materials
collectively
raised
importance
this
protocol
compared
to
previous
challenging
methods.
Furthermore,
mechanistic
cognizance
is
obtained
by
investigation
cyclic
voltammetry
spectra
reactants.
Organic Letters,
Год журнала:
2023,
Номер
25(34), С. 6305 - 6310
Опубликована: Авг. 22, 2023
An
efficient
method
for
the
synthesis
of
bicyclic
spirodiamine
molecules
via
β-C(sp3)–H
bond
activation
aliphatic
amides,
followed
by
cyclization
with
maleimides,
has
been
developed.
The
reaction
proceeds
through
an
amide-directed
alkyl
amides
and
subsequent
maleimides.
methodology
is
highly
compatible
a
wide
variety
Amides
derived
from
biologically
active
fatty
acids
were
also
found
to
be
protocol.
A
palladacycle
was
synthesized
intermediate
in
this
reaction.
plausible
mechanism
proposed
account
spirocyclization.
Achieving
the
site-selective
functionalization
of
unactivated
C(sp3)-H
bonds
remains
a
major
challenge
in
organic
synthesis.
Herein,
we
report
an
efficient
method
for
synthesis
spiro
pyrrolidine
molecules
via
γ-C(sp3)-H
bond
activation
substituted
amino
acids.
A
variety
acid
and
alcohol
derivatives,
as
well
dipeptides,
were
functionalized
using
this
method.
Also,
spirocyclization
optically
active
substrates
provided
potential
route
preparing
separable
diastereomers
pure
enantiomeric
form.
Moreover,
some
mechanistic
insights
have
been
conducted
to
propose
feasible
reaction
mechanism
present
reaction.
Beilstein Journal of Organic Chemistry,
Год журнала:
2025,
Номер
21, С. 770 - 797
Опубликована: Апрель 16, 2025
In
this
review,
we
describe
recent
advances
in
electrochemical
green
methods
for
the
synthesis
of
various
organophosphorus
compounds
through
formation
phosphorus–carbon,
phosphorus–nitrogen,
phosphorus–oxygen,
phosphorus–sulfur,
and
phosphorus–selenium
bonds.
The
impact
different
electrodes
is
also
discussed
matter.
Graphite,
platinum,
RVC,
nickel
have
been
used
extensively
compounds.
made
method
a
promising
preparing
structures.
This
review
an
introduction
to
encourage
scientists
use
electrosynthesis
as
green,
precise,
low-cost
prepare
phosphorous
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(24), С. 17521 - 17526
Опубликована: Ноя. 22, 2023
An
efficient
and
environmentally
friendly
electrochemical
synthesis
of
phosphorylated
oxindoles
indolo[2,1-a]isoquinolin-6(5H)-ones
mediated
by
readily
available
Cp2Fe
has
been
developed,
which
illustrated
a
broad
substrate
scope
diverse
functional
group
compatibility.
This
protocol
featured
an
external
oxidant-free
process
was
at
room
temperature,
proposed
to
be
driven
the
anodic
oxidation
Cp2Fe.
Israel Journal of Chemistry,
Год журнала:
2023,
Номер
64(1-2)
Опубликована: Авг. 23, 2023
Abstract
Despite
substantial
advancements
in
thermal
and
photochemical
catalysis,
the
evolution
of
similar
processes
within
realm
organic
electrochemistry
has
seen
a
slower
pace.
However,
recent
years
have
heralded
remarkable
surge
molecular
electrocatalysis.
This
innovative
technique
harnesses
power
catalysts
to
expedite
electrochemical
transformations.
article
underscores
application
ferrocene
(Fc)
as
redox
catalyst
electrosynthesis.
It
delves
into
extensive
utilization
Fc
electrosynthesis,
particularly
emphasizing
its
role
electrocatalytic
generation
reactions
heteroatom‐
carbon‐centered
radicals,
among
various
other
reactions.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(12)
Опубликована: Фев. 29, 2024
Abstract
Unlike
traditional
organic
methods,
electrosynthesis
has
emerged
as
an
environmentally
friendly
and
sustainable
approach
to
generate
a
series
of
functionalized
compounds.
In
this
process,
the
traceless
electron
serves
redox
agent,
eliminating
need
for
stoichiometric
oxidants
or
reductants.
contrast
direct
electrolysis,
redox‐mediated
electrolysis
ability
overcome
kinetic
inhibitions
achieve
diverse
selectivity
under
mild
conditions.
This
garnered
increasing
attention
from
synthetic
community,
especially
in
past
few
years.
review
will
focus
on
Cp
2
Fe‐mediated
diversified
compounds
through
C−N,
C−C,
C−P
C−O
bond
formation
over
decade.
A
chlorotrimethylsilane
(TMSCl)-mediated
cascade
phosphorylation
and
cycloisomerization
of
enynones
with
diphenylphosphine
oxides
is
presented.
This
methodology
enables
the
highly
selective
synthesis
monophosphorylated
2
